INT59331

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Context Info
Confidence 0.62
First Reported 1993
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 1.91
Pain Relevance 4.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrna9)
Anatomy Link Frequency
spinal 6
neuron 2
cerebral cortex 2
muscle 2
Chrna9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal nerve ligature 24 100.00 Very High Very High Very High
cerebral cortex 2 99.80 Very High Very High Very High
Hippocampus 9 99.14 Very High Very High Very High
Neuropathic pain 3 98.28 Very High Very High Very High
tetrodotoxin 13 97.84 Very High Very High Very High
allodynia 15 97.36 Very High Very High Very High
Action potential 9 96.68 Very High Very High Very High
gABA 2 95.92 Very High Very High Very High
Pyramidal cell 93 94.00 High High
IPN 3 93.08 High High
Disease Link Frequency Relevance Heat
Injury 3 99.04 Very High Very High Very High
Neuropathic Pain 21 98.28 Very High Very High Very High
Inflammatory Pain 3 93.08 High High
Targeted Disruption 3 75.00 Quite High
Cognitive Disorder 12 59.68 Quite High
Toxicity 1 15.76 Low Low
Pheochromocytoma 1 14.32 Low Low
Disease 3 5.00 Very Low Very Low Very Low
Brain Injury 3 5.00 Very Low Very Low Very Low
Schizophrenia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, muscle inactivity caused either by tetrodotoxin or denervation increases cAMP levels and protein kinase A activity, consistent with their proposed role in mediating nAChR gene expression.
Positive_regulation (mediating) of Gene_expression (expression) of nAChR gene in muscle associated with tetrodotoxin
1) Confidence 0.62 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0.23
These results suggest that the increased expression of the alpha5 nAChR subunit following SNL contributes to spinal CREB phosphorylation and the maintenance of mechanical allodynia.
Positive_regulation (increased) of Gene_expression (expression) of nAChR in spinal associated with allodynia and spinal nerve ligature
2) Confidence 0.15 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15652389 Disease Relevance 0.60 Pain Relevance 1.18
Evidence is provided that functional alpha7- and alpha4beta2-like nAChRs are present on somatodendritic and/or preterminal/terminal regions of interneurons in the CA1 field of the rat hippocampus and in the human cerebral cortex and that activation of the different nAChR subtypes present in the preterminal/terminal areas of the interneurons triggers the tetrodotoxin-sensitive release of GABA.
Positive_regulation (activation) of Gene_expression (present) of nAChR in cerebral cortex associated with tetrodotoxin, gaba, hippocampus and cerebral cortex
3) Confidence 0.14 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10942040 Disease Relevance 0 Pain Relevance 0.54
Analysis of the electrophysiological properties, the pharmacological characteristics, and the desensitization behavior of the 2 current components revealed that they were mediated by at least 2 different subtypes of the nAChR, most likely the alpha7-like and the alpha4beta2-like subtype.
Spec (likely) Positive_regulation (mediated) of Gene_expression (alpha7-like) of nAChR
4) Confidence 0.12 Published 2009 Journal Cereb. Cortex Section Abstract Doc Link 18794204 Disease Relevance 0 Pain Relevance 0.42
These results suggest that the increased expression of the alpha5 nAChR subunit following SNL contributes to spinal CREB phosphorylation and the maintenance of mechanical allodynia.
Positive_regulation (contributes) of Gene_expression (expression) of nAChR in spinal associated with allodynia and spinal nerve ligature
5) Confidence 0.11 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15652389 Disease Relevance 0.60 Pain Relevance 1.17
Spinal nerve ligation (SNL) increases the spinal expression of the alpha5 nAChR subunit ipsilateral to injury.
Positive_regulation (increases) of Gene_expression (expression) of nAChR in spinal associated with spinal nerve ligature and injury
6) Confidence 0.10 Published 2005 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15652389 Disease Relevance 0.66 Pain Relevance 0.85
7* nAChR to depolarize and excite the entire neuron that makes it possible for a low density expression of functional ?
Spec (possible) Positive_regulation (possible) of Gene_expression (expression) of nAChR in neuron
7) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0.06 Pain Relevance 0.25

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