INT59332

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Context Info
Confidence 0.55
First Reported 1993
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrna9)
Anatomy Link Frequency
muscle 4
V neurons 2
Chrna9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 31 100.00 Very High Very High Very High
agonist 17 100.00 Very High Very High Very High
antagonist 7 98.76 Very High Very High Very High
tetrodotoxin 8 90.16 High High
GABAergic 10 81.68 Quite High
Action potential 3 73.76 Quite High
Dorsal horn neuron 4 50.00 Quite Low
sodium channel 2 46.24 Quite Low
gABA 8 6.16 Low Low
Spinal cord 28 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 7 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 2 5.00 Very Low Very Low Very Low
Hyperalgesia 1 5.00 Very Low Very Low Very Low
Exsanguination 1 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low
Neuropathic Pain 1 5.00 Very Low Very Low Very Low
Convulsion 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Embryonic-type nicotinic acetylcholine receptor (nAChR) gene expression is regulated by muscle activity.
Regulation (regulated) of Gene_expression (expression) of nAChR in muscle
1) Confidence 0.55 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0
We have addressed this issue by using a rat primary muscle cell culture system that mimics the in vivo effects of muscle activity on nAChR expression.
Regulation (effects) of Gene_expression (expression) of nAChR in muscle
2) Confidence 0.24 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0.07
Effects of nicotine and nAChR agonists on mIPSCs in lamina V neurons
Regulation (Effects) of Gene_expression (agonists) of nAChR in V neurons associated with nicotine and agonist
3) Confidence 0.08 Published 2007 Journal Mol Pain Section Body Doc Link PMC2039725 Disease Relevance 0 Pain Relevance 0.51

General Comments

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