INT59333

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Context Info
Confidence 0.64
First Reported 1993
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 3.23
Pain Relevance 7.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrna9)
Anatomy Link Frequency
longitudinal muscle 1
cerebral cortex 1
sensory nerve 1
boutons 1
dorsal horn 1
Chrna9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 4 99.80 Very High Very High Very High
antinociception 10 99.74 Very High Very High Very High
agonist 118 99.52 Very High Very High Very High
antagonist 42 99.22 Very High Very High Very High
Hippocampus 27 99.14 Very High Very High Very High
Pain 24 99.02 Very High Very High Very High
nociceptor 2 99.02 Very High Very High Very High
Dorsal horn neuron 12 98.04 Very High Very High Very High
Hyperalgesia 3 97.80 Very High Very High Very High
tail-flick 14 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 32 99.28 Very High Very High Very High
Cognitive Disorder 35 99.24 Very High Very High Very High
Stress 3 98.20 Very High Very High Very High
Hyperalgesia 3 97.80 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 6 97.12 Very High Very High Very High
Pain 20 96.88 Very High Very High Very High
Injury 2 96.28 Very High Very High Very High
Targeted Disruption 8 75.00 Quite High
Drug Dependence 3 75.00 Quite High
Ganglion Cysts 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Central administration of MCC activates both NAChR and muscarinic anti-nociceptive mechanisms.
Positive_regulation (activates) of NAChR associated with nociception
1) Confidence 0.64 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8793901 Disease Relevance 0.24 Pain Relevance 0.73
Consistent with this observation, we found enhanced nAChR responses in vitro after a 48 h corticosterone treatment and in vivo after 48 h of repeated stress.
Positive_regulation (enhanced) of nAChR associated with stress
2) Confidence 0.47 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17699659 Disease Relevance 0.39 Pain Relevance 0.56
The biochemical studies also indicated that a sub-population of NAChR receptors are located pre-synaptically on noradrenergic and/or serotoninergic pathways in the hippocampus.
Positive_regulation (sub-population) of NAChR in hippocampus associated with hippocampus
3) Confidence 0.46 Published 1996 Journal Neuropharmacology Section Abstract Doc Link 8793901 Disease Relevance 0.15 Pain Relevance 0.61
Stimulation of nicotinic acetylcholine receptors (nAChR) excites peripheral sensory nerve fibres, but also exert antinociceptive effects.
Positive_regulation (Stimulation) of nAChR in sensory nerve associated with antinociceptive
4) Confidence 0.45 Published 2004 Journal Auton Neurosci Section Abstract Doc Link 15296793 Disease Relevance 0.30 Pain Relevance 0.12
Antagonist of nicotinic acetylcholine receptors (nAChR) enhances formalin-induced nociception in rats: tonic role of nAChRs in the control of pain following injury.
Positive_regulation (enhances) of nAChR associated with nociception, pain, antagonist and injury
5) Confidence 0.40 Published 2001 Journal Brain Res. Section Title Doc Link 11146056 Disease Relevance 0.91 Pain Relevance 1.44
However, these data do not eliminate the possibility that other nicotinic subunit combinations may also play a role in antinociception produced by nAChR activation.
Positive_regulation (activation) of nAChR associated with antinociception
6) Confidence 0.38 Published 2000 Journal Brain Res. Section Abstract Doc Link 10882784 Disease Relevance 0.22 Pain Relevance 0.49
Electrically insensitive genes such as those encoding the adult-type nAChR epsilon-subunit and creatine kinase are not up-regulated by cAMP.
Neg (not) Positive_regulation (up-regulated) of nAChR
7) Confidence 0.36 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0.21
Evidence is provided that functional alpha7- and alpha4beta2-like nAChRs are present on somatodendritic and/or preterminal/terminal regions of interneurons in the CA1 field of the rat hippocampus and in the human cerebral cortex and that activation of the different nAChR subtypes present in the preterminal/terminal areas of the interneurons triggers the tetrodotoxin-sensitive release of GABA.
Positive_regulation (activation) of nAChR in cerebral cortex associated with tetrodotoxin, gaba, hippocampus and cerebral cortex
8) Confidence 0.19 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10942040 Disease Relevance 0 Pain Relevance 0.53
The NCA-evoked responses can be observed at the single-channel level but they do not summate to significant macroscopic currents, suggesting that the major role of NCAs is to act as "co-agonists", thereby potentiating nAChR channel activation by the natural transmitter.
Positive_regulation (activation) of nAChR associated with agonist
9) Confidence 0.15 Published 1995 Journal J. Recept. Signal Transduct. Res. Section Abstract Doc Link 8903949 Disease Relevance 0.07 Pain Relevance 0.45
We aimed at investigating the effect of nicotinic receptor (nAChR) activation on [3H]-acetylcholine ([3H]-ACh) release from longitudinal muscle-myenteric plexus of the rat ileum and to evaluate whether this could be modulated by adenosine, an endogenous neuromodulator typically operating changes in intracellular cyclic AMP.
Spec (investigating) Positive_regulation (activation) of nAChR in longitudinal muscle associated with adenocard
10) Confidence 0.14 Published 2004 Journal Neurochem. Int. Section Abstract Doc Link 15234106 Disease Relevance 0 Pain Relevance 0.12
Not only do alpha7 nAChRs desensitize faster than alpha4beta2 nAChRs, but also alpha7 nAChR desensitization induced by ACh lasts longer than that induced by choline.
Positive_regulation (induced) of nAChR
11) Confidence 0.13 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10942040 Disease Relevance 0 Pain Relevance 0.48
7* nAChR activity is not necessary for detection.
Neg (not) Positive_regulation (necessary) of nAChR
12) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.06
7* nAChR activation by systemic administration of nicotinic agonists has been shown to produce neuroprotection and cognitive benefits [15], [16], [17], [18], [19], [21], [28], [29], [30], [57], [65].
Positive_regulation (activation) of nAChR associated with cognitive disorder and agonist
13) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0.31 Pain Relevance 0.28
7* nAChR activation.
Positive_regulation (activation) of nAChR
14) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2980465 Disease Relevance 0 Pain Relevance 0.23
The aim of this study was to evaluate the effects of nAChR activation on the inhibitory synaptic transmission in deep dorsal horn neurons.


Positive_regulation (activation) of nAChR in dorsal horn associated with dorsal horn neuron
15) Confidence 0.10 Published 2007 Journal Mol Pain Section Body Doc Link PMC2039725 Disease Relevance 0.63 Pain Relevance 0.70
The other is preterminals at terminal axon branches where nAChR activation affects transmitter release by depolarizing axonal membranes to fire action potentials.
Positive_regulation (activation) of nAChR associated with action potential
16) Confidence 0.10 Published 2007 Journal Mol Pain Section Body Doc Link PMC2039725 Disease Relevance 0 Pain Relevance 0.31
One is presynaptic sites or synaptic boutons where nAChR activation modulates transmitter release in a TTX-insensitive manner.
Positive_regulation (activation) of nAChR in boutons
17) Confidence 0.10 Published 2007 Journal Mol Pain Section Body Doc Link PMC2039725 Disease Relevance 0 Pain Relevance 0.34

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