INT59334

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Context Info
Confidence 0.44
First Reported 1993
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 6
Total Number 9
Disease Relevance 0.62
Pain Relevance 3.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Chrna9)
Anatomy Link Frequency
muscle 2
neuronal 1
dorsal 1
dopamine neurons 1
Chrna9 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 43 100.00 Very High Very High Very High
tetrodotoxin 27 100.00 Very High Very High Very High
sodium channel 2 100.00 Very High Very High Very High
agonist 29 99.96 Very High Very High Very High
GABAergic 89 99.12 Very High Very High Very High
Ventral tegmentum 4 97.96 Very High Very High Very High
Dopamine 10 97.80 Very High Very High Very High
Antinociceptive 5 96.60 Very High Very High Very High
antagonist 16 95.36 Very High Very High Very High
intrathecal 2 94.08 High High
Disease Link Frequency Relevance Heat
Nociception 9 97.12 Very High Very High Very High
Pain 6 93.04 High High
Stress 3 80.88 Quite High
Drug Dependence 3 75.00 Quite High
Cognitive Disorder 6 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Repression 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 2 5.00 Very Low Very Low Very Low
Phototoxic Dermatitis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been hypothesized that the action induced is dependent upon the subtype and location of the nAChR activated.
Regulation (dependent) of nAChR
1) Confidence 0.44 Published 2000 Journal Brain Res. Section Abstract Doc Link 10924680 Disease Relevance 0.34 Pain Relevance 0.76
The effects of the nicotinic acetylcholine receptor (nAChR) agonist epibatidine on the extracellular concentrations of dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the dorsal (caudate-putamen) and the ventral striatum (nucleus accumbens) of freely-moving male Wistar rats were studied by in vivo microdialysis.
Regulation (effects) of nAChR in dorsal associated with nucleus accumbens, dopamine and agonist
2) Confidence 0.32 Published 2000 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 11111841 Disease Relevance 0 Pain Relevance 0.33
The nicotinic receptors (nAChR) giving rise to this positive modulation were partly mecamylamine- and partly alpha-bungarotoxin-sensitive.
Regulation (sensitive) of nAChR
3) Confidence 0.27 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 11044734 Disease Relevance 0 Pain Relevance 0.45
Finally, we report that this same mechanism appears to regulate other genes, such as those encoding the tetrodotoxin-insensitive sodium channel, MyoD, and myogenin which, like the nAChR, are regulated by muscle electrical activity.
Spec (appears) Regulation (regulate) of nAChR in muscle associated with tetrodotoxin and sodium channel
4) Confidence 0.24 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0.24
Finally, we report that this same mechanism appears to regulate other genes, such as those encoding the tetrodotoxin-insensitive sodium channel, MyoD, and myogenin which, like the nAChR, are regulated by muscle electrical activity.
Regulation (regulated) of nAChR in muscle associated with tetrodotoxin and sodium channel
5) Confidence 0.24 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0.24
We found a positive correlation between the response to novelty and nAChR function in each assay conducted, including nAChR modulation of glutamatergic and GABAergic synaptic inputs to VTA dopamine neurons, as well as somatic nAChR responses of VTA neurons.
Regulation (modulation) of nAChR in dopamine neurons associated with ventral tegmentum, dopamine and gabaergic
6) Confidence 0.22 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17699659 Disease Relevance 0.29 Pain Relevance 0.55
We examined the effects of nicotine or nAChR agonists on mIPSC frequency in the presence of tetrodotoxin (TTX, 0.5 ?
Spec (examined) Regulation (effects) of nAChR associated with tetrodotoxin, nicotine and agonist
7) Confidence 0.08 Published 2007 Journal Mol Pain Section Body Doc Link PMC2039725 Disease Relevance 0 Pain Relevance 0.53
7-nAChR cluster maintenance is independent of an intact actin cytoskeleton and functional microtubules
Neg (independent) Regulation (independent) of nAChR
8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0 Pain Relevance 0.08
7-nAChR distribution and mobility are modulated by drugs disrupting tubulin or actin, and by neuronal firing or by activation or blockade of ?
Regulation (modulated) of nAChR in neuronal
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901346 Disease Relevance 0 Pain Relevance 0.08

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