INT59335

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Context Info
Confidence 0.30
First Reported 1993
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.81
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Chrna2) plasma membrane (Chrna2)
Anatomy Link Frequency
muscle 3
muscle cell 1
Chrna2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nicotine 7 98.22 Very High Very High Very High
tetrodotoxin 5 97.52 Very High Very High Very High
cerebral cortex 1 85.00 Quite High
Hippocampus 1 84.20 Quite High
Somatosensory cortex 1 58.32 Quite High
anesthesia 1 38.04 Quite Low
sodium channel 1 26.32 Quite Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 4 99.26 Very High Very High Very High
Brain Injury 7 91.96 High High
Injury 4 70.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that nicotine is efficacious at attenuating CCI-induced cognitive deficits in a manner independent of changes in alpha7* nAChr expression, perhaps via up-regulation of non-alpha7* nAChrs.
Regulation (changes) of Gene_expression (expression) of nAChr associated with cognitive disorder and nicotine
1) Confidence 0.30 Published 2003 Journal Neuroscience Section Abstract Doc Link 12831873 Disease Relevance 0.81 Pain Relevance 0.35
Embryonic-type nicotinic acetylcholine receptor (nAChR) gene expression is regulated by muscle activity.
Regulation (regulated) of Gene_expression (expression) of Embryonic-type nicotinic acetylcholine receptor in muscle
2) Confidence 0.20 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8381416 Disease Relevance 0 Pain Relevance 0
Embryonic chick muscle cell cultures treated with the muscle activity blocking agents decamethonium (DCM), d-tubocurare (TBC), and tetrodotoxin (TTX) or co-cultured with cholinergic neurons were examined for the influence of muscle activity on nuclear aggregation and its effects on AChR alpha-, gamma-, and delta-subunit message expression. mRNA was measured by in situ hybridization and nuclei were visualized by bis-benzimide DNA staining.
Regulation (effects) of in muscle cell Gene_expression (expression) of AChR in muscle associated with tetrodotoxin
3) Confidence 0.06 Published 1998 Journal Biochim. Biophys. Acta Section Abstract Doc Link 9459482 Disease Relevance 0 Pain Relevance 0.19

General Comments

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