INT59342

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Context Info
Confidence 0.44
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 20
Total Number 21
Disease Relevance 20.21
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NPC1) nuclear envelope (NPC1) endoplasmic reticulum (NPC1)
lysosome (NPC1)
Anatomy Link Frequency
lung 2
neurogenic regions 1
NPC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
MU agonist 2 99.50 Very High Very High Very High
Pain 8 99.22 Very High Very High Very High
Analgesic 4 99.22 Very High Very High Very High
Enkephalin 2 99.22 Very High Very High Very High
COX-2 inhibitor 7 95.96 Very High Very High Very High
agonist 8 93.60 High High
Neuritis 1 93.48 High High
opioid receptor 4 93.12 High High
ischemia 18 87.04 High High
Morphine 2 86.56 High High
Disease Link Frequency Relevance Heat
Nasopharynx Cancer 1173 100.00 Very High Very High Very High
Carcinoma 70 100.00 Very High Very High Very High
Lymphatic System Cancer 32 100.00 Very High Very High Very High
Cancer 521 99.80 Very High Very High Very High
Neurodegenerative Disease 91 99.56 Very High Very High Very High
Death 23 98.76 Very High Very High Very High
Targeted Disruption 10 98.64 Very High Very High Very High
Paraneoplastic Syndromes 15 98.26 Very High Very High Very High
Disease 158 97.84 Very High Very High Very High
Prostate Cancer 10 96.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was strongly expressed in normal nasopharyngeal mucosa epithelia, but downregulated in NPC.
Negative_regulation (downregulated) of NPC associated with nasopharynx cancer
1) Confidence 0.44 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.41 Pain Relevance 0
The mRNA level of DLC-1 was found to be downregulated in NPC.
Negative_regulation (downregulated) of NPC associated with nasopharynx cancer
2) Confidence 0.44 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.64 Pain Relevance 0
for NPC is still lacking.
Negative_regulation (lacking) of NPC associated with nasopharynx cancer
3) Confidence 0.37 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.71 Pain Relevance 0
technologies and microdissection tools, comprehensive expression profiling of NPC
Negative_regulation (profiling) of NPC associated with nasopharynx cancer
4) Confidence 0.36 Published 2007 Journal Comparative and Functional Genomics Section Body Doc Link PMC2233780 Disease Relevance 1.50 Pain Relevance 0
Opioid agonist properties of two oxime derivatives of naltrexone, NPC 831 and NPC 836.
Negative_regulation (derivatives) of NPC associated with mu agonist
5) Confidence 0.36 Published 1993 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 8381547 Disease Relevance 0 Pain Relevance 1.00
Opioid agonist properties of two oxime derivatives of naltrexone, NPC 831 and NPC 836.
Negative_regulation (derivatives) of NPC associated with mu agonist
6) Confidence 0.36 Published 1993 Journal Pharmacol. Biochem. Behav. Section Title Doc Link 8381547 Disease Relevance 0 Pain Relevance 1.00
The results of removal of recurrent NPC after radiotherapy failure are encouraging for T1–T3 tumors, while those patients with T4 stage generally recur locally or die due to development of metastatic disease.
Negative_regulation (removal) of NPC associated with cancer, nasopharynx cancer and metastasis
7) Confidence 0.32 Published 2010 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2966947 Disease Relevance 0.89 Pain Relevance 0
A matched cohort study to select patients with similar characteristics treated by stereotactic radiosurgery (median dose 12.5 Gy) or intracavitary irradiation (total dose of 60 Gy) was carried out by Chua et al. [33] in 74 patients with local NPC failure, generally at stage rT1–T2.
Negative_regulation (failure) of NPC associated with nasopharynx cancer
8) Confidence 0.32 Published 2010 Journal Eur Arch Otorhinolaryngol Section Body Doc Link PMC2966947 Disease Relevance 0.71 Pain Relevance 0
The result indicated that cancer cells were sensitized to DNA-damaging anticancer drugs through inactivation of MAD2B in NPC [28].
Negative_regulation (inactivation) of NPC associated with nasopharynx cancer and cancer
9) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.17 Pain Relevance 0
in NPC cell lines reduced the tumour volume in nude mice.
Negative_regulation (reduced) of NPC associated with cancer and nasopharynx cancer
10) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.33 Pain Relevance 0
By quantitative reverse transcription polymerase chain reaction (PCR), a candidate tumour suppressor gene BLU/ZMYND10 mapping in the 3p21.3 critical region, was frequently downregulated in NPC cell lines and NPC biopsies [24].
Negative_regulation (downregulated) of NPC associated with nasopharynx cancer and cancer
11) Confidence 0.32 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.51 Pain Relevance 0
Given that prognosis is better when treatment is started at an earlier stage of the disease, it is of major importance to determine the various factors that may possibly contribute to the diagnostic delay of NPC in Indonesia.
Negative_regulation (delay) of NPC associated with nasopharynx cancer and disease
12) Confidence 0.31 Published 2010 Journal BMC Med Educ Section Body Doc Link PMC2998508 Disease Relevance 1.26 Pain Relevance 0.07
PNS may occur before the NPC is manifest, or while it is in an occult stage, and thus the possibility of NPC should be considered in patients with these various disorders.
Negative_regulation (possibility) of NPC associated with nasopharynx cancer and paraneoplastic syndromes
13) Confidence 0.18 Published 2009 Journal Auris Nasus Larynx Section Abstract Doc Link 19111998 Disease Relevance 2.33 Pain Relevance 0.09
We then examined its epigenetic inactivation in NPC and multiple other tumors which have not been studied for this gene, including esophageal, lung, gastric, hepatocellular, colorectal, breast, cervical and prostate carcinomas, as well as non-Hodgkin and Hodgkin lymphomas.
Spec (examined) Negative_regulation (inactivation) of NPC in lung associated with lymphatic system cancer, cancer, nasopharynx cancer and prostate cancer
14) Confidence 0.12 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.50 Pain Relevance 0.12
Our present study further verifies that OPCML can function as a broad TSG and is frequently inactivated epigenetically in multiple carcinomas and lymphomas, including NPC, esophageal, lung, gastric, hepatocellular, colorectal, breast, cervical and prostate carcinomas.
Negative_regulation (inactivated) of NPC in lung associated with lymphatic system cancer, nasopharynx cancer, prostate cancer and carcinoma
15) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2500176 Disease Relevance 1.12 Pain Relevance 0
Spirulina was able to prevent the LPS induced decrease in NPC proliferation.
Negative_regulation (decrease) of NPC
16) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864748 Disease Relevance 0.55 Pain Relevance 0.14
The hypoplastic OB and absent RMS, in concert with reduced expression of NPC survivin in the SurvivinCamcre mice might be caused by decreased NPC proliferation, increased cell death, and/or deficits in migration.
Negative_regulation (decreased) of NPC associated with death
17) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.10 Pain Relevance 0.04
Thus, lack of NPC survivin results in increased embryonic NPC death and decreased NPC proliferation in specific embryonic neurogenic regions.


Negative_regulation (lack) of NPC in neurogenic regions associated with death
18) Confidence 0.03 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2817683 Disease Relevance 0.34 Pain Relevance 0.09
In cells lacking functional NPC1 protein, endocytosed cholesterol accumulates in late endosomes/lysosomes.
Negative_regulation (lacking) of NPC1 protein
19) Confidence 0.02 Published 2003 Journal J. Biol. Chem. Section Abstract Doc Link 12458210 Disease Relevance 0.20 Pain Relevance 0
A similar decrease in hippocampal NPC proliferation was found in COX-2 knock-outs.
Negative_regulation (decrease) of NPC associated with targeted disruption
20) Confidence 0.01 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1764728 Disease Relevance 0.94 Pain Relevance 0.23

General Comments

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