INT59350

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Context Info
Confidence 0.65
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.51
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fosl2) DNA binding (Fosl2)
Anatomy Link Frequency
trigeminal ganglia 1
Fosl2 (Mus musculus)
Pain Link Frequency Relevance Heat
superficial lamina 1 86.48 High High
Kinase C 12 84.28 Quite High
Potency 1 39.12 Quite Low
dexamethasone 10 28.96 Quite Low
Enkephalin 2 25.00 Low Low
cytokine 13 5.00 Very Low Very Low Very Low
Neuropeptide 9 5.00 Very Low Very Low Very Low
amygdala 8 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 2 96.00 Very High Very High Very High
Osteoporosis 21 90.56 High High
Stress 28 76.08 Quite High
Targeted Disruption 11 68.96 Quite High
Calcification 1 49.44 Quite Low
Reprotox - General 1 1 49.00 Quite Low
Hypercalcemia 2 47.24 Quite Low
Hyponatremia 5 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fos B expression is markedly and rapidly enhanced ipsilateral to electrical stimulation of the trigeminal ganglia. c-fos mRNA also changes; these differences contrast with the lack of significant changes in the low basal levels of expression of fra-1 and fra-2 mRNAs.
Gene_expression (expression) of fra-2 in trigeminal ganglia
1) Confidence 0.65 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8381898 Disease Relevance 0.07 Pain Relevance 0.04
The AP1 protein consists of five Fos proteins (c-Fos, Fra-1, Fra-2, FosB, and its natural truncated form ?
Gene_expression (form) of Fra-2
2) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.23 Pain Relevance 0.04
FOSL1 encodes for Fra-1, a component of the dimeric transcription factor activator protein-1 (Ap-1), which is composed mainly of Fos (c-Fos, FosB, Fra-1, and Fra-2) and Jun proteins (c-Jun, JunB, and JunD).
Gene_expression (composed) of Fra-2
3) Confidence 0.01 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.21 Pain Relevance 0

General Comments

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