INT59357

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2011
Negated 2
Speculated 0
Reported most in Abstract
Documents 36
Total Number 36
Disease Relevance 7.81
Pain Relevance 9.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Fosb) DNA binding (Fosb)
Anatomy Link Frequency
neurons 5
neuronal 3
spinal 3
striatum 2
brain 2
Fosb (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 29 99.72 Very High Very High Very High
Nucleus accumbens 26 99.68 Very High Very High Very High
Pain 10 99.56 Very High Very High Very High
Enkephalin 40 99.52 Very High Very High Very High
Hyperalgesia 5 99.44 Very High Very High Very High
cocaine 45 99.30 Very High Very High Very High
Morphine 47 99.12 Very High Very High Very High
withdrawal 5 99.04 Very High Very High Very High
Dynorphin 8 99.00 Very High Very High Very High
Nicotine 52 98.78 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 54 99.78 Very High Very High Very High
Pain 9 99.56 Very High Very High Very High
Hyperalgesia 5 99.44 Very High Very High Very High
Congenital Anomalies 9 99.32 Very High Very High Very High
Dyskinesias 35 98.56 Very High Very High Very High
Chondrosarcoma 1 95.84 Very High Very High Very High
Neuroblastoma 2 95.72 Very High Very High Very High
Heterotopic Ossification 87 93.76 High High
Cancer 4 93.20 High High
Disease 10 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In wild-type mice, repeated nicotine injections, but not a single acute injection, increased the expression of FosB and its truncated variant DeltaFosB in the targets but not at the origins of the mesolimbic and nigrostriatal dopamine pathways; no detectable level of FosB/DeltaFosB was found in KO mice.
Gene_expression (expression) of FosB associated with targeted disruption, dopamine and nicotine
1) Confidence 0.78 Published 2007 Journal Hum. Mol. Genet. Section Abstract Doc Link 17468183 Disease Relevance 0.73 Pain Relevance 0.55
Previous rodent studies have shown that many addictive substances and stressful stimuli increase the expression of the transcription factor FosB in limbic and associated regions and that the protein products of fosB contribute to certain behavioral effects of cocaine and morphine.
Gene_expression (expression) of FosB associated with morphine and cocaine
2) Confidence 0.78 Published 2007 Journal Hum. Mol. Genet. Section Abstract Doc Link 17468183 Disease Relevance 0.36 Pain Relevance 0.45
Because previous work has shown that DeltaFosB overexpression within this same neuronal population increases the rewarding properties of drugs of abuse, results of the present study suggest that DeltaFosB may play a key role in controlling both natural and drug-induced reward.
Gene_expression (overexpression) of DeltaFosB in neuronal
3) Confidence 0.77 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223567 Disease Relevance 0 Pain Relevance 0.16
ERK phosphorylation and FosB expression are associated with L-DOPA-induced dyskinesia in hemiparkinsonian mice.
Gene_expression (expression) of FosB associated with enkephalin and dyskinesias
4) Confidence 0.76 Published 2006 Journal Biol. Psychiatry Section Title Doc Link 16139809 Disease Relevance 0.37 Pain Relevance 0.25
Mice were examined for behavior, expression of FosB, neuropeptides, and externally regulated kinase (ERK) phosphorylation.
Gene_expression (expression) of FosB
5) Confidence 0.76 Published 2006 Journal Biol. Psychiatry Section Body Doc Link 16139809 Disease Relevance 0.18 Pain Relevance 0
Following acute L-DOPA treatment, FosB expression occurs in direct striatal output neurons, whereas chronic L-DOPA also induces FosB expression in nitric oxide synthase-positive striatal interneurons.
Gene_expression (expression) of FosB in interneurons
6) Confidence 0.76 Published 2006 Journal Biol. Psychiatry Section Body Doc Link 16139809 Disease Relevance 0.12 Pain Relevance 0
Following acute L-DOPA treatment, FosB expression occurs in direct striatal output neurons, whereas chronic L-DOPA also induces FosB expression in nitric oxide synthase-positive striatal interneurons.
Gene_expression (expression) of FosB in interneurons
7) Confidence 0.76 Published 2006 Journal Biol. Psychiatry Section Body Doc Link 16139809 Disease Relevance 0.13 Pain Relevance 0
Associated with behavioral alterations, the expression of FosB-like proteins in the nucleus accumbens of the brain was down-regulated in the mice housed in the enriched environmental condition, but not in the standard environment.
Gene_expression (expression) of FosB in brain associated with nucleus accumbens
8) Confidence 0.75 Published 2007 Journal Exp. Neurol. Section Abstract Doc Link 17331503 Disease Relevance 0.14 Pain Relevance 0.64
The finding that reduced GDNF level alters the effects of morphine on striatal dopamine and our previous findings of elevated extracellular striatal dopamine concentrations and FosB/DeltaFosB expression in the GDNF+/- mice show the importance of GDNF in the regulation of striatal dopaminergic system.
Gene_expression (expression) of FosB associated with dopamine and morphine
9) Confidence 0.75 Published 2006 Journal Synapse Section Abstract Doc Link 16437537 Disease Relevance 0.07 Pain Relevance 0.94
This result, taken together with data on stimulation-induced changes in expression of preproenkephalin and other AP-1 transcription factors in wild-type animals and stimulation-induced changes in CAT activity in transgenic mice expressing portions of the proenkephalin promoter, is consistent with a role for the enhanced fos B expression in upregulation of expression of preproenkephalin in these neurons.
Gene_expression (expression) of fos B in neurons associated with targeted disruption
10) Confidence 0.70 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8381898 Disease Relevance 0.10 Pain Relevance 0.03
Fos B expression is markedly and rapidly enhanced ipsilateral to electrical stimulation of the trigeminal ganglia. c-fos mRNA also changes; these differences contrast with the lack of significant changes in the low basal levels of expression of fra-1 and fra-2 mRNAs.
Gene_expression (expression) of Fos B in trigeminal ganglia
11) Confidence 0.70 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8381898 Disease Relevance 0 Pain Relevance 0.05
In wild-type mice, repeated nicotine injections, but not a single acute injection, increased the expression of FosB and its truncated variant DeltaFosB in the targets but not at the origins of the mesolimbic and nigrostriatal dopamine pathways; no detectable level of FosB/DeltaFosB was found in KO mice.
Gene_expression (expression) of DeltaFosB associated with targeted disruption, dopamine and nicotine
12) Confidence 0.68 Published 2007 Journal Hum. Mol. Genet. Section Abstract Doc Link 17468183 Disease Relevance 0.74 Pain Relevance 0.56
In wild-type mice, repeated nicotine injections, but not a single acute injection, increased the expression of FosB and its truncated variant DeltaFosB in the targets but not at the origins of the mesolimbic and nigrostriatal dopamine pathways; no detectable level of FosB/DeltaFosB was found in KO mice.
Neg (no) Gene_expression (detectable) of FosB associated with targeted disruption, dopamine and nicotine
13) Confidence 0.68 Published 2007 Journal Hum. Mol. Genet. Section Abstract Doc Link 17468183 Disease Relevance 0.75 Pain Relevance 0.53
Interestingly, elevated FosB/DeltaFosB expression occurs exclusively within completely lesioned regions of the striatum, displaying an inverse correlation with remaining dopaminergic terminals.
Gene_expression (expression) of FosB in striatum
14) Confidence 0.66 Published 2006 Journal Biol. Psychiatry Section Body Doc Link 16139809 Disease Relevance 0.15 Pain Relevance 0
In wild-type mice, repeated nicotine injections, but not a single acute injection, increased the expression of FosB and its truncated variant DeltaFosB in the targets but not at the origins of the mesolimbic and nigrostriatal dopamine pathways; no detectable level of FosB/DeltaFosB was found in KO mice.
Neg (no) Gene_expression (detectable) of DeltaFosB associated with targeted disruption, dopamine and nicotine
15) Confidence 0.59 Published 2007 Journal Hum. Mol. Genet. Section Abstract Doc Link 17468183 Disease Relevance 0.75 Pain Relevance 0.53
Interestingly, elevated FosB/DeltaFosB expression occurs exclusively within completely lesioned regions of the striatum, displaying an inverse correlation with remaining dopaminergic terminals.
Gene_expression (expression) of DeltaFosB in striatum
16) Confidence 0.58 Published 2006 Journal Biol. Psychiatry Section Body Doc Link 16139809 Disease Relevance 0.15 Pain Relevance 0
Using transgenic mice in which deltaFosB can be induced in adults in the subset of nucleus accumbens neurons in which cocaine induces the protein, we show that deltaFosB expression increases the responsiveness of an animal to the rewarding and locomotor-activating effects of cocaine.
Gene_expression (expression) of deltaFosB in neurons associated with targeted disruption, nucleus accumbens and cocaine
17) Confidence 0.57 Published 1999 Journal Nature Section Abstract Doc Link 10499584 Disease Relevance 0.10 Pain Relevance 0.72
Finally, striatal TH-ir neurones are functionally active, expressing the neuronal activation marker FosB in response to L-DOPA treatment.
Gene_expression (expressing) of FosB in neuronal
18) Confidence 0.55 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18279311 Disease Relevance 0 Pain Relevance 0.31
ERK(1/2) phosphorylation and c-Fos and FosB protein expression were determined with Western blotting, and c-fos and fosB mRNA expression with reverse transcription polymerase chain reaction.
Gene_expression (expression) of FosB
19) Confidence 0.53 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0
Up-regulated mRNA and protein expression of c-fos and fosB was abolished by SB204741, AG1478, and by U0126, an inhibitor of ERK phosphorylation by MAP kinase/ERK kinase.


Gene_expression (expression) of fosB
20) Confidence 0.53 Published 2008 Journal Psychopharmacology (Berl.) Section Body Doc Link 18758753 Disease Relevance 0 Pain Relevance 0

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