INT59358

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Context Info
Confidence 0.61
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 3.70
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Anatomy Link Frequency
neurons 4
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Ventral tegmentum 46 100.00 Very High Very High Very High
Enkephalin 4 100.00 Very High Very High Very High
metalloproteinase 13 98.24 Very High Very High Very High
Kinase C 12 97.28 Very High Very High Very High
substance P 23 96.24 Very High Very High Very High
Inflammatory response 7 96.00 Very High Very High Very High
Inflammation 95 90.16 High High
Arthritis 9 89.20 High High
antagonist 15 88.12 High High
ischemia 6 85.28 High High
Disease Link Frequency Relevance Heat
Stress 44 98.78 Very High Very High Very High
Rheumatoid Arthritis 78 98.32 Very High Very High Very High
Breast Cancer 6 97.84 Very High Very High Very High
Disease 37 97.68 Very High Very High Very High
Targeted Disruption 13 96.20 Very High Very High Very High
INFLAMMATION 112 95.60 Very High Very High Very High
Severe Combined Immunodeficiency 6 95.20 Very High Very High Very High
Arthritis 9 89.20 High High
Apoptosis 40 88.72 High High
Myocardial Stunning 6 88.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As mentioned above, the reports in the literature on AP-1 activation suggest that numerous upstream targets, especially protein kinases, might be involved in signaling pathways that control the expression of AP-1.
Regulation (control) of Gene_expression (expression) of AP-1
1) Confidence 0.61 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.09 Pain Relevance 0.04
Further studies found that the level of expression of several immediate early genes in VTA, as well as other motivation related areas, can be modulated by the specific social context in which males sing [20], [33].
Regulation (modulated) of Gene_expression (expression) of immediate early associated with ventral tegmentum
2) Confidence 0.60 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2533700 Disease Relevance 0.10 Pain Relevance 0.38
This result, taken together with data on stimulation-induced changes in expression of preproenkephalin and other AP-1 transcription factors in wild-type animals and stimulation-induced changes in CAT activity in transgenic mice expressing portions of the proenkephalin promoter, is consistent with a role for the enhanced fos B expression in upregulation of expression of preproenkephalin in these neurons.
Regulation (changes) of Gene_expression (expression) of AP-1 in neurons associated with targeted disruption
3) Confidence 0.44 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8381898 Disease Relevance 0.10 Pain Relevance 0.04
B and AP-1 pathways; silencing of the p65 subunit of NF-?
Regulation (silencing) of Gene_expression (pathways) of AP-1
4) Confidence 0.39 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2632638 Disease Relevance 0.16 Pain Relevance 0.17
Therefore, various kinds of stress may lead to the generation of the divergent and complicated regulation pattern of vasopressin gene expression via the AP1 proteins.
Regulation (regulation) of Gene_expression (expression) of AP1 associated with stress
5) Confidence 0.35 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.19 Pain Relevance 0.20
Analysis of gene expression regulation using pharmacologic tools or A2A receptor-deficient mice (A2A-/-) shows that the A2A receptor positively and tonically controls the expression of enkephalin and immediate early genes in striatopallidal neurons.
Regulation (controls) of Gene_expression (expression) of immediate early in neurons associated with enkephalin
6) Confidence 0.26 Published 2003 Journal Neurology Section Abstract Doc Link 14663005 Disease Relevance 0.36 Pain Relevance 0.33
The proto-oncogene c-fos encodes a nuclear phosphoprotein (c-Fos). c-Fos, in a complex with products of another proto-oncogene, c-jun (AP-1), regulates the expression of AP-1 binding genes at the transcriptional level [8].
Regulation (regulates) of Gene_expression (expression) of AP-1
7) Confidence 0.25 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 1.36 Pain Relevance 0.41
Likewise, luteolin down-regulated complement factor 3, which is regulated by AP1 [68] and blocked expression of Slpi, which is a target of interferon regulatory factor 1 (IRF1) [69].
Regulation (regulated) of Gene_expression (expression) of AP1
8) Confidence 0.16 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2819254 Disease Relevance 0.34 Pain Relevance 0.15
We have provided evidence for a predominant role for AP1 controlling highly expressed NK1R-dependent genes [41].
Regulation (controlling) of Gene_expression (expressed) of AP1
9) Confidence 0.16 Published 2007 Journal BMC Urol Section Body Doc Link PMC1888709 Disease Relevance 0.34 Pain Relevance 0.16
Despite an effect on the expression of c-Jun, as well as on the expression of MMP-1 and MMP-13, however, invasiveness of RA-SFs was not inhibited completely in the SCID mouse model.
Regulation (effect) of Gene_expression (expression) of c-Jun associated with severe combined immunodeficiency and rheumatoid arthritis
10) Confidence 0.02 Published 1999 Journal Arthritis Res Section Body Doc Link PMC128862 Disease Relevance 0.67 Pain Relevance 0.22

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