INT59359

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Context Info
Confidence 0.15
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.69
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Fosl1) nucleus (Fosl1) DNA binding (Fosl1)
Anatomy Link Frequency
trigeminal ganglia 2
nucleus 2
Fosl1 (Mus musculus)
Pain Link Frequency Relevance Heat
superficial lamina 1 87.88 High High
Inflammation 14 52.32 Quite High
Enkephalin 2 25.00 Low Low
cytokine 1 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Antiepileptic agent 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 38 78.20 Quite High
Hyperplasia 2 73.64 Quite High
Targeted Disruption 2 68.16 Quite High
INFLAMMATION 14 52.32 Quite High
Skin Cancer 7 45.20 Quite Low
Toxicity 3 37.96 Quite Low
Body Weight 2 32.16 Quite Low
Stress 9 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fos B expression is markedly and rapidly enhanced ipsilateral to electrical stimulation of the trigeminal ganglia. c-fos mRNA also changes; these differences contrast with the lack of significant changes in the low basal levels of expression of fra-1 and fra-2 mRNAs.
Positive_regulation (changes) of Gene_expression (expression) of fra-1 in trigeminal ganglia
1) Confidence 0.15 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8381898 Disease Relevance 0.07 Pain Relevance 0.04
As summarized in Figure 1B, in the samples from the basal diet group, TPA treatment induced a 2.8-fold increase in Jun D expression and a 2.5-fold increase in Fra-1 expression in the nucleus, compared to a 1.7-fold increase in Jun D and a 1.6-fold increase in Fra-1 in the Protandim diet group.
Positive_regulation (increase) of Gene_expression (expression) of Fra-1 in nucleus
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.62 Pain Relevance 0.03

General Comments

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