INT59365

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 41
Total Number 44
Disease Relevance 16.31
Pain Relevance 16.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1A) signal transducer activity (HTR1A)
Anatomy Link Frequency
motoneurons 3
central nervous system 2
hippocampus 2
HeLa 2
pigmentation 2
HTR1A (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 221 100.00 Very High Very High Very High
agonist 118 100.00 Very High Very High Very High
antagonist 82 100.00 Very High Very High Very High
depression 59 100.00 Very High Very High Very High
substance P 18 100.00 Very High Very High Very High
Analgesic 1 99.96 Very High Very High Very High
melanocortin 1 receptor 3 99.74 Very High Very High Very High
Raphe 8 99.60 Very High Very High Very High
fluoxetine 117 99.52 Very High Very High Very High
Pyramidal cell 60 99.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 69 100.00 Very High Very High Very High
Obesity 19 99.84 Very High Very High Very High
Prostate Cancer 12 99.60 Very High Very High Very High
Migraine Disorders 3 99.28 Very High Very High Very High
Chronic Fatigue Syndrome 14 98.80 Very High Very High Very High
Cognitive Disorder 51 97.96 Very High Very High Very High
Pain 42 97.76 Very High Very High Very High
Genetic Predisposition To Disease 3 97.56 Very High Very High Very High
Pancreatitis 71 97.44 Very High Very High Very High
Nociception 20 96.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Design and synthesis of new potent, silent 5-HT1A antagonists by covalent coupling of aminopropanol derivatives with selective serotonin reuptake inhibitors.
Gene_expression (synthesis) of 5-HT1A associated with antagonist and ssri
1) Confidence 0.75 Published 1998 Journal Bioorg. Med. Chem. Lett. Section Title Doc Link 9873746 Disease Relevance 0 Pain Relevance 0.28
In Ts65Dn mice, fluoxetine treatment restored the expression of 5-HT1A receptors and BDNF.
Gene_expression (expression) of 5-HT1A associated with fluoxetine
2) Confidence 0.75 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592198 Disease Relevance 0.88 Pain Relevance 0.42
The data indicate a convergence of impulsive and aggressive characteristics to one phenotype that is associated with various aspects of serotonin function, such as serotonin release and differential expression of 5-HT1A and 5-HT3 receptors.
Gene_expression (expression) of 5-HT1A associated with serotonin
3) Confidence 0.75 Published 2009 Journal Behav. Neurosci. Section Abstract Doc Link 19485565 Disease Relevance 0.32 Pain Relevance 0.32
The actions of several serotonergic ligands in use or under development for the treatment of migraine headaches were examined at recombinant human 5-HT1A receptors stably expressed in Chinese Hamster Ovary cells.
Gene_expression (expressed) of 5-HT1A in Ovary associated with migraine and headache
4) Confidence 0.75 Published 1997 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 9205951 Disease Relevance 0.25 Pain Relevance 0.37
This study describes a method whereby the degree of receptor reserve, with respect to 5-hydroxytryptamine (5-HT), was determined for a HeLa cell line expressing the human 5-HT1A receptor using the agonist-induced [35S]guanosine 5'[gamma-thio]triphosphate ([35S]GTP gamma S) binding assay, followed by a comparison of the potencies and relative efficacies of several compounds.
Gene_expression (expressing) of 5-HT1A in HeLa associated with agonist
5) Confidence 0.75 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9059863 Disease Relevance 0 Pain Relevance 0.05
In signal transduction assays using cells expressing recombinant h5-HT1D alpha, h5-HT1D beta, or h5-HT1A receptors, alniditan (like 5-HT) was a full agonist for inhibition of stimulated adenylyl cyclase (IC50 = 1.1, 1.3, and 74 nM, respectively, for alniditan).
Gene_expression (expressing) of 5-HT1A associated with agonist
6) Confidence 0.75 Published 1996 Journal Mol. Pharmacol. Section Abstract Doc Link 8967979 Disease Relevance 0.19 Pain Relevance 0.78
In the hippocampus of untreated P15 Ts65Dn mice, we found normal 5-HT levels but a lower expression of 5-HT1A receptors and brain-derived neurotrophic factor (BDNF).
Gene_expression (expression) of 5-HT1A in hippocampus associated with hippocampus
7) Confidence 0.75 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20592198 Disease Relevance 0.90 Pain Relevance 0.43
An immunocytochemical investigation of human trigeminal nucleus caudalis: CGRP, substance P and 5-HT1D-receptor immunoreactivities are expressed by trigeminal sensory fibres.
Gene_expression (expressed) of 5-HT1D-receptor in nucleus associated with substance p
8) Confidence 0.74 Published 2002 Journal Cephalalgia Section Title Doc Link 12133041 Disease Relevance 0 Pain Relevance 0.46
The present study used immunohistochemical and morphometric techniques to determine the proportions of trigeminal fibres expressing substance P, CGRP or 5-HT1D-receptor immunoreactivities.
Gene_expression (expressing) of 5-HT1D-receptor associated with substance p
9) Confidence 0.74 Published 2002 Journal Cephalalgia Section Abstract Doc Link 12133041 Disease Relevance 0 Pain Relevance 0.32
Decreased sensitivity of 5-HT1A and 5-HT1B autoreceptors, which regulate serotonin function, has been associated with depression.13,14 In contrast, the sensitivity of ?
Gene_expression (autoreceptors) of 5-HT1A associated with depression and serotonin
10) Confidence 0.65 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0.89 Pain Relevance 0.91
These findings confirm and extend previous observations in rodents and humans and indicate that both post-synaptic 5-HT1A receptors in the hypothalamus, which mediate hormone responses to 5-HT1A agonists, and pre-synaptic 5-HT1A receptors which (putatively) mediate the hypothermic response, are rendered subsensitive by chronic SSRI administration.
Gene_expression (pre-synaptic) of 5-HT1A in hypothalamus associated with agonist and ssri
11) Confidence 0.65 Published 1999 Journal Neuropsychopharmacology Section Abstract Doc Link 10327431 Disease Relevance 0 Pain Relevance 0.78
5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression.
Gene_expression (depression) of HTR1A associated with depression
12) Confidence 0.65 Published 2009 Journal Neuroreport Section Title Doc Link 19590397 Disease Relevance 0.43 Pain Relevance 0.34
On the other hand, 5-HT1A and 5-HT1D serotonergic receptors do not appear to be involved in the control of AVP secretion during exercise.
Gene_expression (serotonergic receptors) of 5-HT1A
13) Confidence 0.65 Published 2010 Journal Neuropeptides Section Abstract Doc Link 19914713 Disease Relevance 0 Pain Relevance 0.26
In conclusion, our studydoes not provide evidence that the 5HTT, 5-HT1A, 5HT1B,5HT2A and 5HT6 gene polymorphisms play a role in the genetic predisposition to MOH.
Gene_expression (5HTT) of 5-HT1A associated with genetic predisposition to disease and headache
14) Confidence 0.65 Published 2010 Journal J Headache Pain Section Abstract Doc Link 19936617 Disease Relevance 0.94 Pain Relevance 1.18
Antidepressants, such as serotonin or noradrenaline reuptake inhibitors (e.g. fluoxetine, nefadozone) or 5-HT1A agonists (flibanserin), desensitize the 5-HT1A autoreceptor, which may contribute to their clinical efficacy.
Gene_expression (desensitize) of 5-HT1A associated with antidepressant, agonist, noradrenaline, serotonin and fluoxetine
15) Confidence 0.65 Published 2004 Journal Int. J. Neuropsychopharmacol. Section Abstract Doc Link 15447813 Disease Relevance 0.38 Pain Relevance 0.60
Quantitative autoradiography with selective radioligands was used to establish the respective distribution of serotonin 5-HT1A, 5-HT1D, 5-HT2A and 5-HT3 receptors at the cervical, thoracic and lumbar levels of the spinal cord from subjects who died at 81-94 years.
Gene_expression (distribution) of 5-HT1A in spinal cord associated with serotonin and spinal cord
16) Confidence 0.65 Published 1996 Journal J. Chem. Neuroanat. Section Abstract Doc Link 8841890 Disease Relevance 0 Pain Relevance 0.27
RT-PCR products corresponding to the human 5-HT2A, 5-HT1B and 5-HT1F receptors were expressed in high levels, mRNAs coding for 5-HT7, 5-HT1A and 5-HT1D receptors were only weakly expressed.
Gene_expression (expressed) of 5-HT1A
17) Confidence 0.65 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10374714 Disease Relevance 0.07 Pain Relevance 0.26
It can be concluded that HeLa cells, permanently expressing human 5-HT1A receptors, are a valid cellular system for studying the negative coupling of 5-HT1A receptors to adenylate cyclase and the action of compounds thereupon.
Gene_expression (expressing) of 5-HT1A in HeLa
18) Confidence 0.65 Published 1993 Journal Biochem. Pharmacol. Section Abstract Doc Link 8382063 Disease Relevance 0 Pain Relevance 0.64
Anti-OPRM1 antibodies, anti-HTR1A antibodies, and anti-DRD2 antibodies were found in 15.2, 1.7, and 5.0% of patients with CFS, respectively.
Gene_expression (found) of HTR1A associated with chronic fatigue syndrome
19) Confidence 0.64 Published 2003 Journal Int. J. Mol. Med. Section Abstract Doc Link 12851722 Disease Relevance 1.28 Pain Relevance 0.22
Only 5HT1B-receptor protein was detected on dural arteries.
Gene_expression (detected) of 5HT1B-receptor
20) Confidence 0.57 Published 1997 Journal Cephalalgia Section Abstract Doc Link 9453271 Disease Relevance 0.31 Pain Relevance 0.32

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