INT59380

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Context Info
Confidence 0.56
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 4
Disease Relevance 1.20
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prep) peptidase activity (Prep) nucleus (Prep)
cytoplasm (Prep)
Anatomy Link Frequency
joint 2
Prep (Mus musculus)
Pain Link Frequency Relevance Heat
Hyperalgesia 6 85.76 High High
Pain 26 76.60 Quite High
Snapping jaw 2 75.00 Quite High
methotrexate 80 72.48 Quite High
substance P 18 68.76 Quite High
bradykinin 12 68.00 Quite High
tolerance 4 61.40 Quite High
Inflammation 34 58.72 Quite High
Spinal cord 2 48.68 Quite Low
Glutamate 2 48.08 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 12 98.36 Very High Very High Very High
Hyperalgesia 6 85.76 High High
Pain 22 76.60 Quite High
Temporomandibular Joint Syndrome 2 75.00 Quite High
Osteophyte 2 66.64 Quite High
INFLAMMATION 38 58.72 Quite High
Disease 4 57.68 Quite High
Arthritis 4 35.32 Quite Low
Nociception 20 5.00 Very Low Very Low Very Low
Stress 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
POP activity in M?
Transcription (activity) of POP
1) Confidence 0.56 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0.28 Pain Relevance 0.46
administered alone produced a drop between 1.3 to 2.1 on POP activity levels of
Transcription (levels) of POP
2) Confidence 0.56 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2266974 Disease Relevance 0 Pain Relevance 0.06
The histologic changes in the temporo mandibular joint (TMJ) and the activity of serum collagenase-like (CL) peptidase and prolyl endopeptidase (PEP) were compared in mice with spontaneous osteoarthrosis (C57 black mouse/6 Silverberg (C57BL/6S) and control mice (C57 black mouse/6N (C57BL/6N) and ddY).
Transcription (activity) of PEP in joint associated with osteoarthritis
3) Confidence 0.51 Published 1993 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 8383194 Disease Relevance 0.46 Pain Relevance 0.07
The histologic changes in the temporo mandibular joint (TMJ) and the activity of serum collagenase-like (CL) peptidase and prolyl endopeptidase (PEP) were compared in mice with spontaneous osteoarthrosis (C57 black mouse/6 Silverberg (C57BL/6S) and control mice (C57 black mouse/6N (C57BL/6N) and ddY).
Transcription (activity) of prolyl endopeptidase in joint associated with osteoarthritis
4) Confidence 0.51 Published 1993 Journal J. Oral Maxillofac. Surg. Section Abstract Doc Link 8383194 Disease Relevance 0.46 Pain Relevance 0.07

General Comments

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