INT59383

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Context Info
Confidence 0.20
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.94
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il5) extracellular region (Il5)
Anatomy Link Frequency
eosinophils 2
fibroblast 1
Il5 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 63 99.96 Very High Very High Very High
tetrodotoxin 2 99.28 Very High Very High Very High
Action potential 3 99.00 Very High Very High Very High
Inflammation 159 98.52 Very High Very High Very High
sodium channel 1 95.52 Very High Very High Very High
Inflammatory response 12 81.36 Quite High
fibrosis 2 63.68 Quite High
cINOD 2 63.44 Quite High
dexamethasone 30 59.64 Quite High
chemokine 13 55.36 Quite High
Disease Link Frequency Relevance Heat
Asthma 130 99.00 Very High Very High Very High
INFLAMMATION 174 98.52 Very High Very High Very High
Eosinophilia 8 95.56 Very High Very High Very High
Pneumonia 1 93.48 High High
Disease 80 91.84 High High
Hypersensitivity 82 90.28 High High
Bronchitis 9 85.92 High High
Anaphylaxis 33 78.60 Quite High
Occupational Lung Diseases 19 77.44 Quite High
Airway Remodeling 6 74.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it significantly decreased the release of Th2-specific cytokines into the BALF, as exemplified by IL-5 and IL-13 measurements.
IL-5 Binding (exemplified) of associated with cytokine
1) Confidence 0.20 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2898835 Disease Relevance 1.18 Pain Relevance 0.42
, IL-4 and IL-5 in BAL fluid were determined using a Bioplex protein array system (Biorad) with matched antibody pairs for murine TNF-?
IL-5 Binding (fluid) of
2) Confidence 0.20 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.10 Pain Relevance 0.10
This suggests that the function (both survival and mediator release) of BAL eosinophils may be independent of IL-5 [27].
IL-5 Binding (independent) of in eosinophils
3) Confidence 0.16 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.43 Pain Relevance 0.09
By contrast, for expression of more mature action potentials (tetrodotoxin-sensitive) one of the interleukins IL-5, IL-7 or IL-9 must be applied in association with transforming growth factor-alpha after pretreatment with basic fibroblast growth factor.
IL-5 Binding (association) of in fibroblast associated with tetrodotoxin and action potential
4) Confidence 0.11 Published 1993 Journal Nature Section Abstract Doc Link 8383296 Disease Relevance 0 Pain Relevance 0.53
This is a picture that is mirrored in murine models, in which there are numerous reports supporting a role for IL-5 and eosinophils in the 'asthma' response [10,18] but under different experimental conditions bronchial hyper-responsiveness is not dependent on the eosinophil [11,18].
IL-5 Binding (role) of in eosinophil associated with asthma
5) Confidence 0.10 Published 2000 Journal Respir Res Section Body Doc Link PMC59547 Disease Relevance 0.99 Pain Relevance 0.25
, IL-2) and Th2 (IL-5 and IL-6) associated cytokines.
IL-5 Binding (associated) of associated with cytokine
6) Confidence 0.10 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2270279 Disease Relevance 0.24 Pain Relevance 0.30

General Comments

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