INT59384

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Context Info
Confidence 0.75
First Reported 1993
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 23
Total Number 24
Disease Relevance 11.42
Pain Relevance 5.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il7) extracellular region (Il7)
Anatomy Link Frequency
T cell 5
epithelial cells 2
joints 1
stromal cell 1
Leukocyte 1
Il7 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 370 100.00 Very High Very High Very High
Action potential 3 100.00 Very High Very High Very High
tetrodotoxin 2 100.00 Very High Very High Very High
rheumatoid arthritis 725 99.60 Very High Very High Very High
sodium channel 1 99.24 Very High Very High Very High
Arthritis 722 99.00 Very High Very High Very High
Inflammation 570 98.48 Very High Very High Very High
aspirin 2 96.04 Very High Very High Very High
chemokine 49 92.24 High High
Angina 17 89.00 High High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 109 99.96 Very High Very High Very High
Rheumatoid Arthritis 730 99.60 Very High Very High Very High
Cancer 176 99.40 Very High Very High Very High
Necrosis 64 99.16 Very High Very High Very High
Arthritis 684 99.00 Very High Very High Very High
Targeted Disruption 15 98.86 Very High Very High Very High
Arthropathy 11 97.80 Very High Very High Very High
Coronary Artery Disease 34 95.52 Very High Very High Very High
Apoptosis 539 91.92 High High
Obesity 52 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
expression is tightly regulated during postthymic T cell differentiation, such that RTEs (25, 39), naive, and early memory populations (40) express high IL-7R?
Gene_expression (express) of IL-7 in T cell
1) Confidence 0.75 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
Low level IL-7R?
Gene_expression (level) of IL-7
2) Confidence 0.65 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0.04
expression is tightly regulated during postthymic T cell differentiation, such that RTEs (25, 39), naive, and early memory populations (40) express high IL-7R?
Gene_expression (high) of IL-7 in T cell
3) Confidence 0.65 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0 Pain Relevance 0
S1 C), T cell cycling substantially declined after day 7 coincident with IL-7R?
Gene_expression (with) of IL-7 in T cell
4) Confidence 0.65 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0.13 Pain Relevance 0.04
In regard to CD4+CD25Hi regulatory T (T reg) cells, IL-2 plays a major role in their development, maintenance, and expansion, whereas T reg cells express low IL-7R?
Gene_expression (express) of IL-7
5) Confidence 0.58 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2442646 Disease Relevance 0.17 Pain Relevance 0
From these findings, IL-6 signaling, but not IL-7, IL-15, or TGF-?
Neg (not) Gene_expression (but) of IL-7
6) Confidence 0.27 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2373835 Disease Relevance 0.22 Pain Relevance 0.03
Thus, arthritis produced in these mice by the F759 mutation in gp130 required not only homeostatic CD4+ T-cell expansion but upregulation of IL-7 gene expression in nonhemopoietic cells as well.
Gene_expression (expression) of IL-7 in T-cell associated with arthritis
7) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.95 Pain Relevance 0.49
in RA synovial fluid typically increased stromal cell production of IL-7 in vitro.
Gene_expression (production) of IL-7 in stromal cell associated with rheumatoid arthritis
8) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.98 Pain Relevance 0.48
Thus, defective or overexpressed IL-7/IL-7R?
Gene_expression (overexpressed) of IL-7
9) Confidence 0.17 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.55 Pain Relevance 0.29
However, several studies have shown that IEC have the capacity to produce several important immunoregulatory cytokines such as IL-6, IL-7, IL-8, IL-10, tumor necrosis factor-?
Gene_expression (produce) of IL-7 associated with necrosis, cancer and cytokine
10) Confidence 0.17 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2816392 Disease Relevance 0.34 Pain Relevance 0.28
Thus, defective or overexpressed IL-7/IL-7R?
Gene_expression (overexpressed) of IL-7
11) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.55 Pain Relevance 0.29
Thus, defective or overexpressed IL-7/IL-7R?
Gene_expression (defective) of IL-7
12) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.55 Pain Relevance 0.29
Thus, defective or overexpressed IL-7/IL-7R?
Gene_expression (/) of IL-7
13) Confidence 0.15 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.55 Pain Relevance 0.29
By contrast, for expression of more mature action potentials (tetrodotoxin-sensitive) one of the interleukins IL-5, IL-7 or IL-9 must be applied in association with transforming growth factor-alpha after pretreatment with basic fibroblast growth factor.
Gene_expression (expression) of IL-7 in fibroblast associated with tetrodotoxin and action potential
14) Confidence 0.15 Published 1993 Journal Nature Section Abstract Doc Link 8383296 Disease Relevance 0 Pain Relevance 0.55
in the synovial fluid from RA and undifferentiated arthritis patients which strongly correlated with elevated levels of IL-7 and increased numbers of the CD3+ T-cell subset.
Gene_expression (levels) of IL-7 in T-cell associated with rheumatoid arthritis and arthritis
15) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.74 Pain Relevance 0.40
First and foremost would be evidence for elevated levels of IL-7 in the synovial fluid of joints with inflammatory arthritis.
Gene_expression (levels) of IL-7 in joints associated with inflammation and arthritis
16) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.76 Pain Relevance 0.37
In turn, conditional knockout of Stat3 in nonlymphoid cells showed that the increased levels of IL-7 in these mice were Stat3-dependent.
Gene_expression (levels) of IL-7 associated with targeted disruption
17) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 1.02 Pain Relevance 0.48
R blockade did block IL-7 production in those RA patients that responded to anti-TNF-?
Gene_expression (production) of IL-7 associated with rheumatoid arthritis
18) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.84 Pain Relevance 0.44
Furthermore, the gp130 mutation resulted in elevated levels of IL-7.
Gene_expression (levels) of IL-7
19) Confidence 0.13 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2842969 Disease Relevance 0.95 Pain Relevance 0.45
3) Leukocyte developmental: regulating immature white cell growth and differentiation; IL-3 and IL-7 represent this category.
Gene_expression (represent) of IL-7 in Leukocyte
20) Confidence 0.09 Published 2003 Journal Cardiovasc Diabetol Section Body Doc Link PMC212422 Disease Relevance 0.06 Pain Relevance 0

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