INT59388

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Context Info
Confidence 0.66
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 38
Disease Relevance 21.79
Pain Relevance 6.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il9) extracellular region (Il9)
Anatomy Link Frequency
eosinophils 4
mast cell 4
lung 3
T cells 3
fibroblasts 2
Il9 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 1177 100.00 Very High Very High Very High
Action potential 3 100.00 Very High Very High Very High
tetrodotoxin 2 100.00 Very High Very High Very High
Inflammation 888 99.78 Very High Very High Very High
sodium channel 1 99.24 Very High Very High Very High
Neuritis 25 95.88 Very High Very High Very High
fibrosis 77 94.24 High High
chemokine 192 92.44 High High
Inflammatory response 73 82.44 Quite High
nud 1 68.84 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 166 99.98 Very High Very High Very High
Asthma 2726 99.84 Very High Very High Very High
Anaphylaxis 2 99.80 Very High Very High Very High
INFLAMMATION 969 99.78 Very High Very High Very High
Hypersensitivity 614 98.56 Very High Very High Very High
Apoptosis 33 98.48 Very High Very High Very High
Encephalitis 23 98.32 Very High Very High Very High
Food Hypersensitivity 6 96.88 Very High Very High Very High
Colitis 27 96.80 Very High Very High Very High
Metaplasia 69 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Acute OVA challenge (WT vs IL-9 deficient)
Gene_expression (deficient) of IL-9
1) Confidence 0.66 Published 2010 Journal Immunogenetics Section Body Doc Link PMC2910299 Disease Relevance 0.09 Pain Relevance 0
Mast cells can increase in number in response to a variety of mediators other than IL-9 which are expressed following allergen challenge including cytokines that induce mast cell proliferation, i.e., IL-3 (Razin et al. 1984), IL-4 (Mossman et al. 1986), stem-cell factor (Zsebo et al. 1990), and chemokines that may recruit mast cells to the lung (Palmqvist et al. 2007).
Gene_expression (expressed) of IL-9 in mast cell associated with chemokine and cytokine
2) Confidence 0.59 Published 2010 Journal Immunogenetics Section Body Doc Link PMC2910299 Disease Relevance 0.33 Pain Relevance 0.24
Here we show that IL-4 blocked the generation of TGF-beta-induced Foxp3(+) T(reg) cells and instead induced a population of T helper cells that produced IL-9 and IL-10.
Gene_expression (produced) of IL-9
3) Confidence 0.47 Published 2008 Journal Nat. Immunol. Section Abstract Doc Link 18997793 Disease Relevance 0.16 Pain Relevance 0.11
Adoptive transfer of IL-9(+)IL-10(+) T cells into recombination-activating gene 1-deficient mice induced colitis and peripheral neuritis, the severity of which was aggravated if the IL-9(+)IL-10(+) T cells were transferred with CD45RB(hi) CD4(+) effector T cells.
Gene_expression (transfer) of IL-9 in effector T cells associated with colitis and neuritis
4) Confidence 0.47 Published 2008 Journal Nat. Immunol. Section Abstract Doc Link 18997793 Disease Relevance 0.19 Pain Relevance 0.13
Transgenic IL-9 overexpressing mice have increased levels of immunoglobulin isotypes including IgE and expansion of lymphocytes from the B1 subset (Mac+IgM+).
Gene_expression (overexpressing) of IL-9 in lymphocytes associated with targeted disruption
5) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.34 Pain Relevance 0.03
Several studies showed IL-9 mRNA and protein expression in the lymphocytes of bronchoalveolar lavage and CD3+ T cells in bronchial tissue from asthmatics [18, 19].
Gene_expression (expression) of IL-9 in T cells associated with occupational lung diseases
6) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.70 Pain Relevance 0.04
Expression of the IL-9 receptor ?
Gene_expression (Expression) of IL-9
7) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.26 Pain Relevance 0.08
The question how exactly iNKT cells fit into the large picture of asthma-immunopathology remains unanswered and is even complicated by the recent observations that iNKT cells additionally produce IL-9, IL-17, and IL-22 [191–193].

8.

Gene_expression (produce) of IL-9 associated with asthma
8) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.62 Pain Relevance 0.04
TH2 cells have been regarded as a major source of IL-9 production [17].
Gene_expression (production) of IL-9
9) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.71 Pain Relevance 0.04
However, some studies have suggested that IL-9-induced mucus expression is mediated via IL-13 [56, 57].
Gene_expression (expression) of IL-9-induced
10) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.23 Pain Relevance 0.30
These cells were named TH9 cells because they produce IL-9 in large amounts [20, 21].
Gene_expression (produce) of IL-9
11) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.52 Pain Relevance 0.08
One has to keep in mind that several inflammatory cells can express IL-9 in bronchial asthma.
Gene_expression (express) of IL-9 associated with asthma and inflammation
12) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 1.22 Pain Relevance 0.23
In that study, analysis of the murine IL-9 gene identified a genetic defect at the C57BL/6(B6)IL-9 locus associated with a lack of IL-9 expression in the lung and reduced AHR in naive B6 mice.
Gene_expression (expression) of IL-9 in lung
13) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.33 Pain Relevance 0.11
Selective overexpression of the IL-9 gene in the airways of transgenic mice resulted in massive airway inflammation, with infiltration of eosinophils and lymphocytes, mast cell hyperplasia, and increased subepithelial collagen deposition [39, 44, 49].
Gene_expression (overexpression) of IL-9 gene in eosinophils associated with targeted disruption, inflammation and hyperplasia
14) Confidence 0.25 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.47 Pain Relevance 0.11
By contrast, for expression of more mature action potentials (tetrodotoxin-sensitive) one of the interleukins IL-5, IL-7 or IL-9 must be applied in association with transforming growth factor-alpha after pretreatment with basic fibroblast growth factor.
Gene_expression (expression) of IL-9 in fibroblast associated with tetrodotoxin and action potential
15) Confidence 0.22 Published 1993 Journal Nature Section Abstract Doc Link 8383296 Disease Relevance 0 Pain Relevance 0.55
The tight genotype-phenotype relation was further supported by the finding that (B6D2)F1 mice were found to be intermediate in both lung IL-9 levels and airway responsiveness.
Gene_expression (levels) of IL-9 in lung
16) Confidence 0.21 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.44 Pain Relevance 0.11
can “reprogram” the differentiation of T helper cells to an IL-9 producing phenotype, the so-called TH9 cell [20].
Gene_expression (producing) of IL-9
17) Confidence 0.21 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.36 Pain Relevance 0.08
In that same study, an increased expression and production of IL-9 in the lung was associated with AHR in DBA/J2 mice.
Gene_expression (production) of IL-9 in lung
18) Confidence 0.21 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.34 Pain Relevance 0.11
Several studies showed IL-9 mRNA and protein expression in the lymphocytes of bronchoalveolar lavage and CD3+ T cells in bronchial tissue from asthmatics [18, 19].
Gene_expression (expression) of IL-9 in T cells associated with occupational lung diseases
19) Confidence 0.21 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.70 Pain Relevance 0.04
These TH9 cells produce IL-9 and IL-10.
Gene_expression (produce) of IL-9
20) Confidence 0.19 Published 2010 Journal Journal of Allergy Section Body Doc Link PMC2957587 Disease Relevance 0.27 Pain Relevance 0.18

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