INT5939

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 1982
Last Reported 2010
Negated 0
Speculated 4
Reported most in Abstract
Documents 27
Total Number 31
Disease Relevance 2.84
Pain Relevance 9.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
posterior pituitary 10
PVH 8
neurons 8
brain 6
CSF 2
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 185 100.00 Very High Very High Very High
Opioid 22 100.00 Very High Very High Very High
Acupuncture 20 100.00 Very High Very High Very High
addiction 6 100.00 Very High Very High Very High
tolerance 4 100.00 Very High Very High Very High
Deafferentation 2 100.00 Very High Very High Very High
fluoxetine 2 100.00 Very High Very High Very High
narcan 11 99.86 Very High Very High Very High
Enkephalin 12 99.84 Very High Very High Very High
analgesia 9 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 47 100.00 Very High Very High Very High
Anxiety Disorder 18 99.72 Very High Very High Very High
Infection 2 98.60 Very High Very High Very High
Hyponatremia 3 97.72 Very High Very High Very High
Pressure And Volume Under Development 1 92.56 High High
Aids-related Complex 17 89.20 High High
Natriuresis 3 88.40 High High
Urological Neuroanatomy 37 82.32 Quite High
Dysmenorrhea 1 78.40 Quite High
Wound Healing 69 75.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of anesthetic stress on the major hormones of the posterior pituitary (PP), such as oxytocin (OT), oxytocin-neurophysin (OTNP-I) and its metabolic product, OTNP-II, was studied.
Regulation (effect) of Gene_expression (product) of OT in posterior pituitary associated with stress
1) Confidence 0.51 Published 1991 Journal Life Sci. Section Abstract Doc Link 1943445 Disease Relevance 0.10 Pain Relevance 0.18
Focussing on an immune challenge model (since infection is a major cause of preterm labour in women), we have found that the responsiveness of oxytocin neurons to IL-1beta is markedly suppressed in late pregnancy.
Regulation (responsiveness) of Gene_expression (neurons) of oxytocin in neurons associated with infection
2) Confidence 0.45 Published 2008 Journal Prog. Brain Res. Section Abstract Doc Link 18655896 Disease Relevance 0.26 Pain Relevance 0.22
Suckling, oxytocin infusion and mammary nerve stimulation in anesthetized rats raised VIP levels significantly from 13 +/- 2, 18 +/- 5 and 10 +/- 2 to 43 +/- 8, 45 +/- 16 and 53 +/- 22 pM, respectively, whereas oxytocin levels rose from 111 +/- 34 to 294 +/- 66 pM after 20 min of suckling and to a peak value of 500 +/- 70 pM after oxytocin infusion.
Regulation (rose) of Gene_expression (levels) of oxytocin in nerve
3) Confidence 0.44 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2109267 Disease Relevance 0.07 Pain Relevance 0
It is furthermore proposed that the placebo response in trials may be predicted by circulating plasma OXT levels, the OXT receptor density in the brain and/or the presence of one or more of the single nucleotide polymorphisms of the OXT promoter gene.
Regulation (circulating) of Gene_expression (levels) of OXT receptor in brain
4) Confidence 0.44 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309413 Disease Relevance 0 Pain Relevance 0.19
The effect of acupuncture on the concentrations of arginine vasopressin (AVP), oxytocin (OXT), leucine-enkephaline (L-Ek), beta-endorphin (beta-Ep) and dynorphinA(1-13) (DynA(1-13)) was investigated in rat PVH.
Spec (investigated) Regulation (effect) of Spec (investigated) Gene_expression (concentrations) of oxytocin in PVH associated with acupuncture
5) Confidence 0.44 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16459202 Disease Relevance 0.07 Pain Relevance 0.59
The effect of anesthetic stress on the major hormones of the posterior pituitary (PP), such as oxytocin (OT), oxytocin-neurophysin (OTNP-I) and its metabolic product, OTNP-II, was studied.
Regulation (effect) of Gene_expression (product) of oxytocin-neurophysin in posterior pituitary associated with stress
6) Confidence 0.43 Published 1991 Journal Life Sci. Section Abstract Doc Link 1943445 Disease Relevance 0.10 Pain Relevance 0.18
The effect of anesthetic stress on the major hormones of the posterior pituitary (PP), such as oxytocin (OT), oxytocin-neurophysin (OTNP-I) and its metabolic product, OTNP-II, was studied.
Regulation (effect) of Gene_expression (product) of oxytocin in posterior pituitary associated with stress
7) Confidence 0.43 Published 1991 Journal Life Sci. Section Abstract Doc Link 1943445 Disease Relevance 0.10 Pain Relevance 0.18
The effect of anesthetic stress on the major hormones of the posterior pituitary (PP), such as oxytocin (OT), oxytocin-neurophysin (OTNP-I) and its metabolic product, OTNP-II, was studied.
Regulation (effect) of Gene_expression (product) of oxytocin-neurophysin in posterior pituitary associated with stress
8) Confidence 0.43 Published 1991 Journal Life Sci. Section Abstract Doc Link 1943445 Disease Relevance 0.10 Pain Relevance 0.18
Effects of subacute opioid administration during late pregnancy in the rat on the initiation, duration and outcome of parturition and maternal levels of oxytocin and arginine vasopressin.
Regulation (Effects) of Gene_expression (levels) of oxytocin associated with opioid
9) Confidence 0.40 Published 1989 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 2721029 Disease Relevance 0 Pain Relevance 0.37
It is furthermore proposed that the placebo response in trials may be predicted by circulating plasma OXT levels, the OXT receptor density in the brain and/or the presence of one or more of the single nucleotide polymorphisms of the OXT promoter gene.
Regulation (circulating) of Gene_expression (levels) of OXT in brain
10) Confidence 0.39 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19309413 Disease Relevance 0 Pain Relevance 0.19
The effect of acupuncture on the concentrations of arginine vasopressin (AVP), oxytocin (OXT), leucine-enkephaline (L-Ek), beta-endorphin (beta-Ep) and dynorphinA(1-13) (DynA(1-13)) was investigated in rat PVH.
Spec (investigated) Regulation (effect) of Spec (investigated) Gene_expression (concentrations) of OXT in PVH associated with acupuncture
11) Confidence 0.39 Published 2006 Journal Brain Res. Bull. Section Abstract Doc Link 16459202 Disease Relevance 0.07 Pain Relevance 0.59
Environmental enrichment (EE) fosters attachment behavior through its effect on brain oxytocin levels in the hippocampus and other brain regions, which in turn modulate the hypothalamic-pituitary axis (HPA).
Regulation (effect) of Gene_expression (levels) of oxytocin in pituitary associated with hippocampus
12) Confidence 0.38 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2677672 Disease Relevance 0.34 Pain Relevance 0.05
In rats, both vasopressin and oxytocin neurones in the supraoptic nucleus are osmosensitive and have contrasting roles in these adaptations.
Regulation (osmosensitive) of Gene_expression (neurones) of oxytocin in supraoptic nucleus
13) Confidence 0.36 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 19258663 Disease Relevance 0.43 Pain Relevance 0
Since stress and opioids affect oxytocin secretion we investigated the involvement of corticotrophin-releasing hormone (CRH) and enkephalin on the regulation of oxytocin production during pregnancy and parturition by measuring CRH, proenkephalin A (PENK) and oxytocin mRNA's in the paraventricular nucleus (PVN) using quantitative in situ hybridisation.
Spec (investigated) Regulation (regulation) of Gene_expression (production) of oxytocin in nucleus associated with stress, enkephalin and opioid
14) Confidence 0.33 Published 1994 Journal Gene Ther. Section Abstract Doc Link 8542431 Disease Relevance 0.10 Pain Relevance 0.20
Naloxone also increased (p less than 0.05) oxytocin concentration in controls receiving CSF or saline.
Regulation (controls) of Gene_expression (concentration) of oxytocin associated with narcan
15) Confidence 0.32 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 3796791 Disease Relevance 0 Pain Relevance 0.40
2AR antagonists are able to allosterically modulate oxytocin receptor signaling and oxytocin receptor trafficking and, vice versa, an oxytocin antagonist can modulate ?
Regulation (modulate) of Gene_expression (antagonist) of oxytocin associated with antagonist
16) Confidence 0.28 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0 Pain Relevance 0.10
Thus, during the peripartum period, a population of limbic neurons sensitive to oxytocin display a dynamically changing pattern of excitatory responses, apparently modulated by an endogenous opioid cone and independent of changes in oxytocin receptor expression.
Regulation (changes) of Gene_expression (expression) of oxytocin in neurons associated with endogenous opioid
17) Confidence 0.26 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300435 Disease Relevance 0 Pain Relevance 0.25
The 5-HT precursor, 5-hydroxytryptophan, injected in combination with the 5-HT reuptake inhibitor, fluoxetine, increased oxytocin mRNA expression in the PVN, and the concentration of vasopressin and oxytocin in plasma, whereas mRNA in the SON was not affected.
Regulation (injected) of Gene_expression (expression) of oxytocin in PVN associated with fluoxetine
18) Confidence 0.25 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716407 Disease Relevance 0.09 Pain Relevance 0.44
Opioid tolerance and dependence in the magnocellular oxytocin system: a physiological mechanism?
Regulation (dependence) of Gene_expression (system) of oxytocin associated with addiction, tolerance and opioid
19) Confidence 0.24 Published 1995 Journal Exp. Physiol. Section Title Doc Link 7640004 Disease Relevance 0 Pain Relevance 1.03
Opioid tolerance and dependence in the magnocellular oxytocin system: a physiological mechanism?
Regulation (tolerance) of Gene_expression (system) of oxytocin associated with addiction, tolerance and opioid
20) Confidence 0.24 Published 1995 Journal Exp. Physiol. Section Title Doc Link 7640004 Disease Relevance 0 Pain Relevance 1.03

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox