INT5940

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Context Info
Confidence 0.59
First Reported 1980
Last Reported 2010
Negated 12
Speculated 2
Reported most in Abstract
Documents 236
Total Number 239
Disease Relevance 67.86
Pain Relevance 101.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Avp) extracellular space (Avp) extracellular region (Avp)
response to stress (Avp) signal transducer activity (Avp)
Anatomy Link Frequency
plasma 41
nucleus 8
hypothalamus 6
posterior pituitary 6
blood 6
Avp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 280 100.00 Very High Very High Very High
visual analogue scale 200 100.00 Very High Very High Very High
Enkephalin 150 100.00 Very High Very High Very High
Dynorphin 105 100.00 Very High Very High Very High
gABA 101 100.00 Very High Very High Very High
Serotonin 90 100.00 Very High Very High Very High
Somatostatin 81 100.00 Very High Very High Very High
substance P 63 100.00 Very High Very High Very High
Pain score 49 100.00 Very High Very High Very High
depression 49 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 430 100.00 Very High Very High Very High
Stress 90 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 71 100.00 Very High Very High Very High
Bacillus Anthracis Infection 57 100.00 Very High Very High Very High
Depression 52 100.00 Very High Very High Very High
Hypoglycemia 21 99.98 Very High Very High Very High
Diuresis 64 99.92 Very High Very High Very High
Hemorrhage 48 99.92 Very High Very High Very High
Cv General 3 Under Development 14 99.90 Very High Very High Very High
Urological Neuroanatomy 78 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone treatment, in contrast, significantly decreased AVP mRNA expression levels in the PVN, but this inhibitory action was abolished in the presence of DRB or the sodium channel blocker tetrodotoxin (TTX).
Negative_regulation (decreased) of AVP mRNA in PVN associated with tetrodotoxin, sodium channel and dexamethasone
1) Confidence 0.59 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 14614081 Disease Relevance 0 Pain Relevance 0.57
BACKGROUND: Arginine vasopressin (AVP) and terlipressin were proposed as alternatives to catecholamines in shock states characterized by decreased plasma AVP concentrations.
Negative_regulation (decreased) of AVP in plasma associated with catecholamine and shock
2) Confidence 0.59 Published 2006 Journal Anesthesiology Section Abstract Doc Link 16571969 Disease Relevance 0.44 Pain Relevance 0.05
The elevated plasma AVP level in response to short-term hypotension induced by intravenous infusion of sodium nitroprusside was also significantly reduced by i.c.v. administration of L-NAME.
Negative_regulation (reduced) of AVP in plasma associated with pressure volume 2 under development
3) Confidence 0.59 Published 1996 Journal Neurosci. Lett. Section Abstract Doc Link 9014178 Disease Relevance 0.10 Pain Relevance 0.12
In water-deprived rats, U-62,066E markedly inhibited plasma arginine vasopressin (AVP) levels through a kappa receptor-mediated mechanism.
Negative_regulation (inhibited) of AVP in plasma
4) Confidence 0.58 Published 1989 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2547626 Disease Relevance 0.20 Pain Relevance 0.25
Either alpha 2-adrenergic receptor blockade (yohimbine) or occupancy (clonidine) prevent NPY inhibition of AVP-stimulated Lp.
Negative_regulation (inhibition) of AVP-stimulated Lp associated with clonidine
5) Confidence 0.58 Published 1989 Journal Am. J. Physiol. Section Abstract Doc Link 2538078 Disease Relevance 0.09 Pain Relevance 0.22
Pretreatment with naloxone, an antagonist of opioids at their receptors, did not reduce the vasopressin levels (47.7 +/- 9 pg/ml).
Neg (not) Negative_regulation (reduce) of vasopressin associated with antagonist, narcan and opioid
6) Confidence 0.58 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3681699 Disease Relevance 0.09 Pain Relevance 0.83
Bremazocine and U-50, 488 (kappa agonists) markedly suppressed vasopressin levels, whereas morphine and methadone (mu agonists) and metkephamid (a mixed mu and delta agonist) did not suppress vasopressin levels.
Neg (not) Negative_regulation (suppress) of vasopressin associated with mu agonist, agonist, methadone and morphine
7) Confidence 0.58 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2991502 Disease Relevance 0.07 Pain Relevance 0.92
Likewise, clonidine, a potent diuretic in normally hydrated rats, did not clearly suppress vasopressin levels.
Neg (not) Negative_regulation (suppress) of vasopressin associated with clonidine
8) Confidence 0.58 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2991502 Disease Relevance 0.13 Pain Relevance 0.91
These results support the hypothesis that kappa opioid agonists produce a diuretic effect by suppressing plasma levels of vasopressin, and at higher doses produce a pattern of urination similar to animals lacking vasopressin.
Negative_regulation (suppressing) of vasopressin in plasma associated with mu agonist and overactive bladder
9) Confidence 0.58 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2991502 Disease Relevance 0.17 Pain Relevance 0.94
Bremazocine and U-50, 488 (kappa agonists) markedly suppressed vasopressin levels, whereas morphine and methadone (mu agonists) and metkephamid (a mixed mu and delta agonist) did not suppress vasopressin levels.
Negative_regulation (suppressed) of vasopressin associated with mu agonist, agonist, methadone and morphine
10) Confidence 0.58 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2991502 Disease Relevance 0.07 Pain Relevance 0.85
The administration of ANF III in conscious euhydrated rats resulted in a significant reduction of both AVP and OXT contents in the hippocampus.
Negative_regulation (reduction) of AVP in hippocampus associated with hippocampus
11) Confidence 0.58 Published 1988 Journal Exp. Clin. Endocrinol. Section Abstract Doc Link 2978124 Disease Relevance 0.16 Pain Relevance 0.19
Based on Figure one of Graugaard-Jensen et al. 2006 (but with a 12 hours phase since rat are active during night and rest during the day), we introduced the following modulation: at 2 AM, the level of AVP is reduced in a linear function of time until a nadir of -30% is reached at 8 AM.
Negative_regulation (reduced) of AVP
12) Confidence 0.58 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2939538 Disease Relevance 0.17 Pain Relevance 0
Both naloxone and a structurally-related congener, naltrexone (0.01-10 mg/kg), attenuated water consumption is a dose-related fashion of 1 hr water-deprived homozygotes, which exhibit a complete absence of vasopressin.
Negative_regulation (absence) of vasopressin associated with narcan
13) Confidence 0.58 Published 1981 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7291218 Disease Relevance 0.17 Pain Relevance 0.68
The full kappa agonists (ethylketazocine, U-50,488, tifluadom and MR-2034) suppressed plasma vasopressin levels below the threshold of detectability of the radioimmunoassay, whereas the partial kappa agonists (nalorphine and butorphanol) suppressed vasopressin levels compared with control values but did not have the efficacy of the full kappa agonists.
Negative_regulation (suppressed) of vasopressin in plasma associated with butorphanol and agonist
14) Confidence 0.57 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3039112 Disease Relevance 0.15 Pain Relevance 0.52
All these results support the hypothesis that kappa agonists produce their diuretic effect by suppression of plasma vasopressin levels.
Negative_regulation (suppression) of vasopressin in plasma associated with agonist
15) Confidence 0.57 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 3039112 Disease Relevance 0.15 Pain Relevance 0.48
Kappa agonist-induced diuresis: evidence for stereoselectivity, strain differences, independence of hydration variables and a result of decreased plasma vasopressin levels.
Negative_regulation (decreased) of vasopressin in plasma associated with diuresis, agonist and sprains and strains
16) Confidence 0.57 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 3039112 Disease Relevance 0.30 Pain Relevance 0.35
NaCl was considered to be mostly abolished by blockade of the sympathetic nervous system (SNS), and to be partly diminished by the vascular receptor blockade of vasopressin (AVP), in the conscious animals.
Negative_regulation (blockade) of AVP in SNS
17) Confidence 0.57 Published 1989 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2505699 Disease Relevance 0.24 Pain Relevance 0.07
This agonist markedly increased the urine volume in normally hydrated rats and suppressed plasma AVP in a dose-dependent manner in rats given hyperosmolar saline.
Negative_regulation (suppressed) of AVP in plasma associated with agonist
18) Confidence 0.57 Published 1988 Journal Neuroendocrinology Section Abstract Doc Link 3251164 Disease Relevance 0.25 Pain Relevance 0.37
The results support the hypothesis that the inhibition of vasopressin by diprenorphine is due to antagonism of an opioid receptor and suggest that it is one of the recently discovered kappa-subtypes.
Negative_regulation (inhibition) of vasopressin associated with opioid receptor
19) Confidence 0.55 Published 1994 Journal Endocrinology Section Abstract Doc Link 8275969 Disease Relevance 0.25 Pain Relevance 0.63
In the similarly prepared SAD group, plasma level of vasopressin was decreased and plasma level of oxytocin was increased significantly to the same extent as in the SHAM group after low-frequency shocks (0.05 Hz, 5 min) or environmental cue signals previously paired with shocks.
Negative_regulation (decreased) of vasopressin in plasma associated with shock
20) Confidence 0.53 Published 1992 Journal Neurosci. Res. Section Abstract Doc Link 1319020 Disease Relevance 0.57 Pain Relevance 0.20

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