INT5941

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Context Info
Confidence 0.76
First Reported 1980
Last Reported 2010
Negated 3
Speculated 3
Reported most in Abstract
Documents 164
Total Number 178
Disease Relevance 22.63
Pain Relevance 65.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
neurons 21
nucleus 14
plasma 11
brain 10
posterior pituitary 7
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1068 100.00 Very High Very High Very High
agonist 505 100.00 Very High Very High Very High
Neuropeptide 251 100.00 Very High Very High Very High
Enkephalin 148 100.00 Very High Very High Very High
opiate 28 100.00 Very High Very High Very High
Somatostatin 25 100.00 Very High Very High Very High
Cholecystokinin 3 100.00 Very High Very High Very High
antinociception 83 99.96 Very High Very High Very High
depression 43 99.92 Very High Very High Very High
withdrawal 36 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 44 99.92 Very High Very High Very High
Stress 273 99.84 Very High Very High Very High
Anxiety Disorder 150 99.76 Very High Very High Very High
Pain 173 99.74 Very High Very High Very High
Volume Depletion And Dehydration 18 99.56 Very High Very High Very High
Cocaine Dependence 2 99.52 Very High Very High Very High
Hyponatremia 76 99.48 Very High Very High Very High
Infection 12 99.48 Very High Very High Very High
Reprotox - General 1 15 99.40 Very High Very High Very High
Inflammatory Pain 5 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma levels of vasoactive intestinal polypeptide and oxytocin in response to suckling, electrical stimulation of the mammary nerve and oxytocin infusion in rats.
Gene_expression (levels) of oxytocin in nerve associated with anesthesia
1) Confidence 0.76 Published 1990 Journal Neuroendocrinology Section Title Doc Link 2109267 Disease Relevance 0.09 Pain Relevance 0.10
Thus, during the peripartum period, a population of limbic neurons sensitive to oxytocin display a dynamically changing pattern of excitatory responses, apparently modulated by an endogenous opioid cone and independent of changes in oxytocin receptor expression.
Gene_expression (expression) of oxytocin in neurons associated with endogenous opioid
2) Confidence 0.75 Published 1997 Journal Neuroscience Section Abstract Doc Link 9300435 Disease Relevance 0 Pain Relevance 0.25
There was a negative relationship between the PVN AVP concentration and the pain threshold; pain stimulation enhanced the AVP, not OXT mRNA expression in the PVN using in situ hybridization and RT-PCR; intraventricular injection of anti-AVP serum completely reversed L-glutamate sodium injection into the PVN-induced antinociception, and administration of naloxone - the opiate peptide antagonist, partly blocked this L-glutamate sodium effect, but anti-OXT serum pretreatment did not influence this L-glutamate sodium effect; L-glutamate sodium injection into the PVN-induced analgesia was inhibited by V2 receptor antagonist - d(CH2)5[D-Ile2, Ile4, Ala-NH2(9)]AVP, not V1 receptor antagonist - d(CH2)5Tyr(Me)AVP.
Gene_expression (expression) of OXT mRNA in PVN associated with antinociception, pain, glutamate, pain threshold, antagonist, narcan, opiate and analgesia
3) Confidence 0.75 Published 2006 Journal Brain Res. Section Abstract Doc Link 16409991 Disease Relevance 0.49 Pain Relevance 1.75
ISH first showed that chronic morphine treatment inhibited the oxytocin synthesis in SON but not in PVN.
Gene_expression (synthesis) of oxytocin in SON associated with morphine
4) Confidence 0.75 Published 2000 Journal Neuroreport Section Abstract Doc Link 11043533 Disease Relevance 0.09 Pain Relevance 0.87
These data indicate that pharmacological amounts of oxytocin produce antinociception, that occurs through the activation of oxytocin receptors; endogenous opioid systems seem to be involved altogether.
Gene_expression (produce) of oxytocin associated with antinociception and endogenous opioid
5) Confidence 0.74 Published 1993 Journal Neuropeptides Section Abstract Doc Link 8474630 Disease Relevance 0.15 Pain Relevance 0.66
The effect of anesthetic stress on the major hormones of the posterior pituitary (PP), such as oxytocin (OT), oxytocin-neurophysin (OTNP-I) and its metabolic product, OTNP-II, was studied.
Gene_expression (product) of oxytocin in posterior pituitary associated with stress
6) Confidence 0.74 Published 1991 Journal Life Sci. Section Abstract Doc Link 1943445 Disease Relevance 0.10 Pain Relevance 0.18
The effect of anesthetic stress on the major hormones of the posterior pituitary (PP), such as oxytocin (OT), oxytocin-neurophysin (OTNP-I) and its metabolic product, OTNP-II, was studied.
Gene_expression (product) of oxytocin-neurophysin in posterior pituitary associated with stress
7) Confidence 0.74 Published 1991 Journal Life Sci. Section Abstract Doc Link 1943445 Disease Relevance 0.10 Pain Relevance 0.18
Effects of subacute opioid administration during late pregnancy in the rat on the initiation, duration and outcome of parturition and maternal levels of oxytocin and arginine vasopressin.
Gene_expression (levels) of oxytocin associated with opioid
8) Confidence 0.69 Published 1989 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 2721029 Disease Relevance 0 Pain Relevance 0.37
Sexual impotence is associated with a reduced production of oxytocin and with an increased production of opioid peptides in the paraventricular nucleus of male rats.
Gene_expression (production) of oxytocin in nucleus associated with enkephalin, opioid and reprotox - general 1
9) Confidence 0.68 Published 1997 Journal Neurosci. Lett. Section Title Doc Link 9350833 Disease Relevance 0.10 Pain Relevance 0.53
These data suggest that an imbalance in the production of oxytocin and of opioid peptides in the PVN, with prevalence of opioid peptides, may underlie a condition of sexual impotence.
Gene_expression (production) of oxytocin in PVN associated with opioid and reprotox - general 1
10) Confidence 0.68 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9350833 Disease Relevance 0.17 Pain Relevance 0.45
Interestingly, some of these reward orexigens, such as opioids, diminish activity of neurons synthesizing oxytocin, a nonapeptide that promotes satiety and feeding termination.
Gene_expression (synthesizing) of oxytocin in neurons associated with opioid
11) Confidence 0.68 Published 2010 Journal Peptides Section Abstract Doc Link 20399242 Disease Relevance 0 Pain Relevance 0.10
Plasma oxytocin levels 40 min after delivery of the first fetus were 45.25 +/- 3.6 pmol/l (mean +/- S.D.) in unoperated controls and significantly (P less than 0.01) depressed (23.89 +/- 3.9) in rats that delivered during infusion of relaxin.
Gene_expression (levels) of oxytocin in Plasma
12) Confidence 0.68 Published 1986 Journal J. Endocrinol. Section Abstract Doc Link 3783086 Disease Relevance 0 Pain Relevance 0.24
Subcutaneous injection of oxytocin (OXT-(1-9)) and of its behaviorally active fragments desglycinamide9-oxytocin (OXT-(1-8)) and [pGlu4,Cyt6]-oxytocin-(4-8) (OXT-(4-8)) decreased the amount of heroin self-injected.
Gene_expression (injection) of oxytocin
13) Confidence 0.68 Published 1985 Journal Life Sci. Section Abstract Doc Link 4058258 Disease Relevance 0 Pain Relevance 0.21
However, intravenous injection of oxytocin or anti-oxytocin serum did not influence acupuncture analgesia.
Gene_expression (injection) of oxytocin associated with acupuncture and analgesia
14) Confidence 0.67 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17664006 Disease Relevance 0.24 Pain Relevance 1.22
However, intravenous injection of oxytocin or anti-oxytocin serum did not influence acupuncture analgesia.
Gene_expression (injection) of anti-oxytocin associated with acupuncture and analgesia
15) Confidence 0.67 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17664006 Disease Relevance 0.24 Pain Relevance 1.23
A set of oxytocin antagonists consisting of [Mpa1Sar7Arg8]-oxytocin substituted by various conformationally restricted or bulky D amino acids at position 2 were synthetized and biologically tested.
Gene_expression (synthetized) of oxytocin associated with antagonist
16) Confidence 0.67 Published 1999 Journal Peptides Section Abstract Doc Link 10477131 Disease Relevance 0 Pain Relevance 0.17
Keeping oxytocin neurons under control during stress in pregnancy.
Gene_expression (neurons) of oxytocin in neurons associated with stress
17) Confidence 0.67 Published 2008 Journal Prog. Brain Res. Section Title Doc Link 18655896 Disease Relevance 0.24 Pain Relevance 0.16
Oxytocin synthesised by magnocellular neurons in the supraoptic and paraventricular nuclei plays an important role in mammalian parturition.
Gene_expression (synthesised) of Oxytocin in neurons
18) Confidence 0.67 Published 2008 Journal Prog. Brain Res. Section Abstract Doc Link 18655896 Disease Relevance 0.13 Pain Relevance 0.06
Focussing on an immune challenge model (since infection is a major cause of preterm labour in women), we have found that the responsiveness of oxytocin neurons to IL-1beta is markedly suppressed in late pregnancy.
Gene_expression (neurons) of oxytocin in neurons associated with infection
19) Confidence 0.67 Published 2008 Journal Prog. Brain Res. Section Abstract Doc Link 18655896 Disease Relevance 0.25 Pain Relevance 0.21
The paraventricular nucleus (PVN) of the hypothalamus is an important source of brain oxytocin (OT).
Gene_expression (source) of oxytocin in nucleus
20) Confidence 0.67 Published 2008 Journal Pain Section Abstract Doc Link 18823708 Disease Relevance 0.53 Pain Relevance 0.82

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