INT59433

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Context Info
Confidence 0.68
First Reported 1993
Last Reported 2010
Negated 4
Speculated 2
Reported most in Body
Documents 24
Total Number 28
Disease Relevance 25.13
Pain Relevance 3.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PASK) Golgi apparatus (PASK) nucleus (PASK)
cytoplasm (PASK) signal transducer activity (PASK)
Anatomy Link Frequency
impression 2
glands 2
endothelial cell 1
internal 1
synapses 1
PASK (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 138 100.00 Very High Very High Very High
antagonist 28 100.00 Very High Very High Very High
Central nervous system 2 99.68 Very High Very High Very High
long-term potentiation 2 99.60 Very High Very High Very High
depression 714 97.24 Very High Very High Very High
Transcranial magnetic stimulation 8 93.44 High High
epidural 2 84.16 Quite High
Spinal cord 3 83.64 Quite High
Pain 81 81.92 Quite High
Multiple sclerosis 14 79.32 Quite High
Disease Link Frequency Relevance Heat
Suicidal Behaviour 4765 100.00 Very High Very High Very High
Cancer 335 99.86 Very High Very High Very High
Breast Cancer 184 99.84 Very High Very High Very High
Death 908 98.92 Very High Very High Very High
Depression 742 97.24 Very High Very High Very High
Disease 103 96.60 Very High Very High Very High
Unconsciousness 92 95.88 Very High Very High Very High
Overdose 210 95.08 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 115 91.72 High High
Leukemia 14 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of present paper was to investigate the central nervous system level at which PAS produces its effects.
Gene_expression (produces) of PAS in central nervous system associated with central nervous system
1) Confidence 0.68 Published 2009 Journal Cereb. Cortex Section Abstract Doc Link 19176639 Disease Relevance 0.08 Pain Relevance 0.39
Indirect data support the hypothesis that the enhancement of MEPs produced by PAS involves long-term potentiation like changes in cortical synapses.
Gene_expression (produced) of PAS in synapses associated with long-term potentiation
2) Confidence 0.67 Published 2009 Journal Cereb. Cortex Section Abstract Doc Link 19176639 Disease Relevance 0.07 Pain Relevance 0.36
As another way of positively experiencing PAS, one doctor described the pleasure of embracing death while controlling its process so that it is done 'right' through PAS: "You know, it's an odd thing, and you've probably heard this from other physicians, but if you don't sidestep the process of dying, it becomes almost as pleasurable a thing helping people die right as giving birth...And done well, the process of helping somebody die right is very rewarding" (pp 458) [24].
Gene_expression (experiencing) of PAS associated with suicidal behaviour and death
3) Confidence 0.66 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.68 Pain Relevance 0.07
Those who rely on this safeguard to prevent the provision of PAS to clinically depressed, suicidal patients further assume that when depression is recognized, PAS will not proceed.
Gene_expression (provision) of PAS associated with suicidal behaviour and depression
4) Confidence 0.66 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.47 Pain Relevance 0.35
Diane asked Quill for PAS saying she wanted to be in control.
Spec (asked) Gene_expression (asked) of PAS associated with suicidal behaviour
5) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.12 Pain Relevance 0
The paper is framed in terms of the anticipated effects of PAS for UK doctors who would deal with these requests and addresses the following questions: What do doctors actually do in PAS?
Gene_expression (effects) of PAS associated with suicidal behaviour
6) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.09 Pain Relevance 0
The paper is framed in terms of the anticipated effects of PAS for UK doctors who would deal with these requests and addresses the following questions: What do doctors actually do in PAS?
Gene_expression (do) of PAS associated with suicidal behaviour
7) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.18 Pain Relevance 0.05
This individual did not obtain another PAS prescription and died 14 days later of the underlying illness [6].
Gene_expression (prescription) of PAS associated with suicidal behaviour
8) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.66 Pain Relevance 0.14
As shown by the examples above, countries that legalize PAS or euthanasia using safeguards such as in Lord Joffe's bill can decrease but not eliminate the number of patients who are inappropriately assisted in suicide despite not meeting PAS criteria.
Gene_expression (legalize) of PAS associated with suicidal behaviour
9) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.23 Pain Relevance 0.11
Then, in a disorienting shift, Kevorkian moves the group's focus onto what is clearly an essential part of his agenda in providing PAS: his interest in organ donation and human experimentation.
Gene_expression (providing) of PAS associated with suicidal behaviour
10) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 0.77 Pain Relevance 0.12
An Oregon doctor who provides PAS said, "...
Gene_expression (provides) of PAS associated with suicidal behaviour
11) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 0.83 Pain Relevance 0
The British Geriatrics Society opposes PAS and considers elderly patients to be vulnerable to its misuse [13].
Gene_expression (opposes) of PAS associated with suicidal behaviour
12) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.22 Pain Relevance 0
The titles of Quill's publications on Diane's case reinforce the impression that he values PAS as an expression of control and autonomy: 'Death and dignity: a case of individualized decision making' [34] and 'Death and Dignity: Making Choices and Taking Charge' [36].
Gene_expression (expression) of PAS in impression associated with suicidal behaviour and death
13) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.04 Pain Relevance 0
The studies also give the impression that doctors who do not provide PAS often continue to avoid talking about death altogether.
Neg (not) Gene_expression (provide) of PAS in impression associated with suicidal behaviour and death
14) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.67 Pain Relevance 0.08
Timothy Quill, an American internal medicine physician who is a PAS proponent.
Gene_expression (proponent) of PAS in internal associated with suicidal behaviour
15) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.05 Pain Relevance 0
PAS requests may express rage: rage at the doctor for distancing himself or for not providing a cure, rage at the world, or rage at themselves.
Gene_expression (express) of PAS associated with suicidal behaviour
16) Confidence 0.57 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 0.86 Pain Relevance 0.08
Tumor cells in the epithelial layer were negative for periodic acid Schiff (PAS) and alcian blue, but partly positive for epithelial membrane antigen (EMA) and CEA, whereas those in the submucosal ducts and glands were strongly positive for PAS, alcian blue, carcinoembryonic antigen, and EMA, especially at their luminal surfaces.
Neg (negative) Gene_expression (negative) of PAS in glands associated with cancer
17) Confidence 0.35 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 8385166 Disease Relevance 1.21 Pain Relevance 0.07
Following PAS methodology, GR went through many trial sessions and discussed with the experimenters how to best characterize her experiences.
Gene_expression (methodology) of PAS
18) Confidence 0.17 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2507770 Disease Relevance 0 Pain Relevance 0
Tumor cells in the epithelial layer were negative for periodic acid Schiff (PAS) and alcian blue, but partly positive for epithelial membrane antigen (EMA) and CEA, whereas those in the submucosal ducts and glands were strongly positive for PAS, alcian blue, carcinoembryonic antigen, and EMA, especially at their luminal surfaces.
Neg (negative) Gene_expression (negative) of PAS in ducts associated with cancer
19) Confidence 0.12 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 8385166 Disease Relevance 1.21 Pain Relevance 0.07
Our thesis and conclusion is that deeper emotional reactions reflect a different relationship in cases of E and PAS in comparison with the doctor-patient relationship of LAWER, but also in comparison to normal care, even with patients with a terminal disease.


Gene_expression (relationship) of PAS associated with suicidal behaviour and disease
20) Confidence 0.10 Published 2010 Journal Med Health Care Philos Section Body Doc Link PMC2949557 Disease Relevance 0.28 Pain Relevance 0

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