INT59434

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Context Info
Confidence 0.49
First Reported 1993
Last Reported 2006
Negated 1
Speculated 1
Reported most in Body
Documents 4
Total Number 12
Disease Relevance 16.64
Pain Relevance 2.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (PASK) Golgi apparatus (PASK) nucleus (PASK)
cytoplasm (PASK) signal transducer activity (PASK)
Anatomy Link Frequency
impression 4
ducts 1
glands 1
PASK (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 459 99.52 Very High Very High Very High
metalloproteinase 46 99.20 Very High Very High Very High
palliative 99 98.96 Very High Very High Very High
Spinal cord 1 80.48 Quite High
Pain 48 78.76 Quite High
pain pelvic 9 62.00 Quite High
Multiple sclerosis 9 56.32 Quite High
tolerance 9 13.60 Low Low
antidepressant 18 5.00 Very Low Very Low Very Low
Opioid 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Suicidal Behaviour 3051 100.00 Very High Very High Very High
Recurrence 9 99.86 Very High Very High Very High
Depression 477 99.52 Very High Very High Very High
Death 576 99.08 Very High Very High Very High
Cancer 158 99.00 Very High Very High Very High
Disease 63 98.56 Very High Very High Very High
Mental Disorders 117 97.84 Very High Very High Very High
Overdose 135 88.00 High High
Heart Rate Under Development 9 86.48 High High
Cognitive Disorder 9 85.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both studies [24,30] give the impression that for doctors who participate in PAS, PAS is the necessary stimulus to deal with death in a way that is meaningful and adequate for patients, and the doctors thereafter associate provision of PAS with the gratifying experiences of mastering death and of achieving a special relationship with their patients.
Positive_regulation (necessary) of PAS in impression associated with suicidal behaviour and death
1) Confidence 0.49 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.56 Pain Relevance 0.09
Guilt may motivate PAS requests in patients who equate their illness with personal failure.
Spec (may) Positive_regulation (motivate) of PAS associated with suicidal behaviour
2) Confidence 0.49 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.02 Pain Relevance 0.10
Tumor cells in the epithelial layer were negative for periodic acid Schiff (PAS) and alcian blue, but partly positive for epithelial membrane antigen (EMA) and CEA, whereas those in the submucosal ducts and glands were strongly positive for PAS, alcian blue, carcinoembryonic antigen, and EMA, especially at their luminal surfaces.
Positive_regulation (positive) of PAS in glands associated with cancer
3) Confidence 0.47 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 8385166 Disease Relevance 1.18 Pain Relevance 0.06
In conclusion, studies that systematically assess depression in terminally ill individuals do not show that all requests for PAS arise from depression, but they do provide robust evidence that depression plays a role in the desire for a hastened death, including PAS or euthanasia, in a significant proportion of those with terminal illness.
Positive_regulation (requests) of PAS associated with suicidal behaviour, depression and death
4) Confidence 0.43 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.94 Pain Relevance 0.52
In turn, requests for PAS can affect the quality of treatment of mental illness and distress: Patients with mental illness who then develop a terminal disease can receive substandard treatment for their psychiatric relapses after requesting PAS, partly because doctors become confused by the competing interests of PAS and clinical care [16] (Table 3).


Positive_regulation (requesting) of PAS associated with mental disorders, suicidal behaviour, disease and recurrence
5) Confidence 0.43 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 2.19 Pain Relevance 0.31
Doctors can experience PAS very positively.
Positive_regulation (experience) of PAS associated with suicidal behaviour
6) Confidence 0.43 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.32 Pain Relevance 0.09
Certainly he is not representative of the average doctor who provides PAS.
Positive_regulation (provides) of PAS associated with suicidal behaviour
7) Confidence 0.40 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 0.96 Pain Relevance 0.09
The studies also give the impression that doctors who do not provide PAS often continue to avoid talking about death altogether.
Neg (not) Positive_regulation (provide) of PAS in impression associated with suicidal behaviour and death
8) Confidence 0.40 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.67 Pain Relevance 0.08
The titles of Quill's publications on Diane's case reinforce the impression that he values PAS as an expression of control and autonomy: 'Death and dignity: a case of individualized decision making' [34] and 'Death and Dignity: Making Choices and Taking Charge' [36].
Positive_regulation (values) of PAS in impression associated with suicidal behaviour and death
9) Confidence 0.40 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 0.99 Pain Relevance 0
Both studies [24,30] give the impression that for doctors who participate in PAS, PAS is the necessary stimulus to deal with death in a way that is meaningful and adequate for patients, and the doctors thereafter associate provision of PAS with the gratifying experiences of mastering death and of achieving a special relationship with their patients.
Positive_regulation (necessary) of PAS in impression associated with suicidal behaviour and death
10) Confidence 0.22 Published 2006 Journal BMC Fam Pract Section Body Doc Link PMC1550404 Disease Relevance 1.56 Pain Relevance 0.09
Tumor cells in the epithelial layer were negative for periodic acid Schiff (PAS) and alcian blue, but partly positive for epithelial membrane antigen (EMA) and CEA, whereas those in the submucosal ducts and glands were strongly positive for PAS, alcian blue, carcinoembryonic antigen, and EMA, especially at their luminal surfaces.
Positive_regulation (positive) of PAS in ducts associated with cancer
11) Confidence 0.16 Published 1993 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 8385166 Disease Relevance 1.18 Pain Relevance 0.06
Cancer cells express matrix metalloproteinases (MMPs) and the plasminogen activator system (PAS) [1-3] and their levels of expression increase with progression of the tumour.
Positive_regulation (increase) of PAS associated with cancer and metalloproteinase
12) Confidence 0.05 Published 2005 Journal Cancer Cell Int Section Body Doc Link PMC548674 Disease Relevance 1.06 Pain Relevance 0.52

General Comments

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