INT59447

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.56
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 12
Total Number 14
Disease Relevance 4.57
Pain Relevance 3.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cytoplasm (Tyr)
Anatomy Link Frequency
melanocytes 4
Tyr (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 34 100.00 Very High Very High Very High
Antinociceptive 1 99.60 Very High Very High Very High
opioid receptor 1 97.92 Very High Very High Very High
antagonist 2 97.28 Very High Very High Very High
narcan 3 95.04 Very High Very High Very High
antinociception 6 93.00 High High
Delta opioid receptors 2 75.00 Quite High
Pain 1 25.00 Low Low
anesthesia 60 5.00 Very Low Very Low Very Low
ketamine 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ocular Hypertension 507 99.82 Very High Very High Very High
Hypopigmentation 12 99.68 Very High Very High Very High
Targeted Disruption 4 99.62 Very High Very High Very High
Skin Cancer 3 98.52 Very High Very High Very High
Congenital Anomalies 3 97.64 Very High Very High Very High
Experimental Melanoma 3 90.88 High High
Microphthalmia 9 79.92 Quite High
Stress 6 75.00 Quite High
Glaucoma 51 61.96 Quite High
Sprains And Strains 261 56.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we extend this animal model by developing a compound mutant transgenic amelanotic animal defective at both the melanocortin 1 receptor (Mc1r) and tyrosinase (Tyr) loci.
Negative_regulation (defective) of tyrosinase associated with targeted disruption and melanocortin 1 receptor
1) Confidence 0.56 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.18 Pain Relevance 0.10
Here, we extend this animal model by developing a compound mutant transgenic amelanotic animal defective at both the melanocortin 1 receptor (Mc1r) and tyrosinase (Tyr) loci.
Negative_regulation (defective) of Tyr associated with targeted disruption and melanocortin 1 receptor
2) Confidence 0.49 Published 2009 Journal Pigment Cell Melanoma Res Section Abstract Doc Link 19682281 Disease Relevance 0.18 Pain Relevance 0.10
Mouse E(+)/E(+) melanocytes, but not e/e or E(so)/E(so) melanocytes, respond to agouti signaling protein with decreased basal tyrosinase activity, and reduction in levels of tyrosinase and tyrosinase-related proteins 1 and 2.
Negative_regulation (decreased) of tyrosinase in melanocytes
3) Confidence 0.42 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11181184 Disease Relevance 0 Pain Relevance 0.55
This indicates that reduction in tyrosinase activity affects pheomelanogenesis more profoundly compared with eumelanogenesis.
Negative_regulation (reduction) of tyrosinase
4) Confidence 0.41 Published 2001 Journal Pigment Cell Res. Section Abstract Doc Link 11277491 Disease Relevance 0 Pain Relevance 0.07
Here, we show increased IOP in mice lacking tyrosinase activity compared to otherwise genetically identical pigmented B6 mice.
Negative_regulation (lacking) of tyrosinase associated with ocular hypertension
5) Confidence 0.40 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.04 Pain Relevance 0
Tyrosinase deficiency causes albinism and has various ocular consequences.
Negative_regulation (deficiency) of Tyrosinase associated with hypopigmentation
6) Confidence 0.40 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 1.05 Pain Relevance 0
Tyrosinase deficiency results in increased IOP
Negative_regulation (deficiency) of Tyrosinase associated with ocular hypertension
7) Confidence 0.40 Published 2001 Journal BMC Genet Section Body Doc Link PMC48141 Disease Relevance 0.98 Pain Relevance 0
Mouse E(+)/E(+) melanocytes, but not e/e or E(so)/E(so) melanocytes, respond to agouti signaling protein with decreased basal tyrosinase activity, and reduction in levels of tyrosinase and tyrosinase-related proteins 1 and 2.
Negative_regulation (reduction) of tyrosinase in melanocytes
8) Confidence 0.31 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11181184 Disease Relevance 0 Pain Relevance 0.55
Mouse E(+)/E(+) melanocytes, but not e/e or E(so)/E(so) melanocytes, respond to agouti signaling protein with decreased basal tyrosinase activity, and reduction in levels of tyrosinase and tyrosinase-related proteins 1 and 2.
Negative_regulation (reduction) of tyrosinase in melanocytes
9) Confidence 0.31 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11181184 Disease Relevance 0 Pain Relevance 0.55
The activity of the rate-limiting melanogenic enzyme, tyrosinase, decreased in H(2)O(2)-treated mouse and human melanoma cells.
Negative_regulation (decreased) of tyrosinase associated with skin cancer
10) Confidence 0.23 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11493672 Disease Relevance 0.34 Pain Relevance 0
Inhibition of enzyme activities reflected decreased protein levels. mRNAs for tyrosinase, tyrosinase-related protein 1, dopachrome tautomerase, silver protein and melanocortin 1 receptor also decreased after H(2)O(2) treatment, and recovered at different rates.
Negative_regulation (decreased) of tyrosinase associated with melanocortin 1 receptor
11) Confidence 0.17 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11493672 Disease Relevance 0.40 Pain Relevance 0.10
Inhibition of enzyme activities reflected decreased protein levels. mRNAs for tyrosinase, tyrosinase-related protein 1, dopachrome tautomerase, silver protein and melanocortin 1 receptor also decreased after H(2)O(2) treatment, and recovered at different rates.
Negative_regulation (decreased) of tyrosinase associated with melanocortin 1 receptor
12) Confidence 0.17 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11493672 Disease Relevance 0.39 Pain Relevance 0.10
Mouse E(+)/E(+) melanocytes, but not e/e or E(so)/E(so) melanocytes, respond to agouti signaling protein with decreased basal tyrosinase activity, and reduction in levels of tyrosinase and tyrosinase-related proteins 1 and 2.
Negative_regulation (reduction) of tyrosinase in melanocytes
13) Confidence 0.13 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11181184 Disease Relevance 0 Pain Relevance 0.55
The antinociceptive effect of systemic L-Tyr-OMe was also inhibited by naltrindole (0.1 mg/kg s.c.), a selective delta-opioid receptor antagonist, but was resistant to L-leucyl-L-arginine (3 micrograms/mouse i.c.v.), a kyotorphin (L-tyrosyl-L-arginine) receptor antagonist.
Negative_regulation (inhibited) of L-Tyr-OMe associated with antagonist, opioid receptor and antinociceptive
14) Confidence 0.08 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8385625 Disease Relevance 0 Pain Relevance 0.66

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox