INT59449

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Context Info
Confidence 0.42
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 76
Total Number 76
Disease Relevance 54.86
Pain Relevance 26.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
extracellular matrix 5
fibroblasts 3
chondrocytes 2
lung 2
temporomandibular joint 2
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 1435 100.00 Very High Very High Very High
rheumatoid arthritis 845 99.40 Very High Very High Very High
Inflammation 853 99.32 Very High Very High Very High
fibrosis 551 99.28 Very High Very High Very High
Inflammatory response 56 99.00 Very High Very High Very High
cytokine 409 98.96 Very High Very High Very High
Osteoarthritis 127 98.86 Very High Very High Very High
Arthritis 398 98.32 Very High Very High Very High
Snapping jaw 30 96.68 Very High Very High Very High
dexamethasone 46 96.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 300 99.76 Very High Very High Very High
Cancer 581 99.68 Very High Very High Very High
Alzheimer's Dementia 33 99.64 Very High Very High Very High
Colon Cancer 19 99.64 Very High Very High Very High
Osteoarthritis 149 99.56 Very High Very High Very High
Rheumatoid Arthritis 855 99.40 Very High Very High Very High
Necrosis 106 99.40 Very High Very High Very High
INFLAMMATION 876 99.32 Very High Very High Very High
Fibrosis 517 99.28 Very High Very High Very High
Systemic Sclerosis 335 99.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
bFGF = basic fibroblast growth factor; COX = cyclo-oxygenase; DMEM = Dulbecco's modified Eagle's medium; EGF = epidermal growth factor; ERK = extracellular signal-regulated kinase; GRO = growth related protein; IBC = inflammatory breast cancer; IL = interleukin; MMP = matrix metalloproteinase; PG = prostaglandin; RBC = red blood cell; siRNA = small interfering RNA; TIMP = tissue inhibitor of matrix metalloproteinase; VEGF = vascular endothelial growth factor; VM = vasculogenic mimicry.


Negative_regulation (inhibitor) of TIMP in red blood cell associated with inflammatory breast neoplasms, inflammation and metalloproteinase
1) Confidence 0.42 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.47 Pain Relevance 0.20
Tissue inhibitor of metalloproteinase type (TIMP)-1 is a multifunctional glycoprotein which inhibits most matrix metalloproteinases (MMPs).
Negative_regulation (inhibitor) of TIMP associated with metalloproteinase
2) Confidence 0.42 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956090 Disease Relevance 1.28 Pain Relevance 0.17
The cell culture supernatants of vehicle treated cells had greater amounts of growth related protein (GRO), IL-6, IL-8, tissue inhibitor of matrix metalloproteinase (TIMP)1 and TIMP2, and VEGF, based on gray levels or brightness values as compared with cells treated with celecoxib.
Negative_regulation (inhibitor) of TIMP associated with metalloproteinase
3) Confidence 0.41 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0 Pain Relevance 0.10
The kinetics of cerebrospinal fluid (CSF) MMP and tissue inhibitors of MMPs (TIMPs) concentrations were studied in a subset of HIV uninfected adults (n?
Negative_regulation (inhibitors) of TIMP in CSF associated with acquired immune deficiency syndrome or hiv infection and metalloproteinase
4) Confidence 0.41 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2748711 Disease Relevance 0.45 Pain Relevance 0.50
Metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPS) play key roles in extracellular matrix remodeling and degradation.
Negative_regulation (inhibitors) of Metalloproteinases in extracellular matrix associated with metalloproteinase
5) Confidence 0.38 Published 2003 Journal Histochem. Cell Biol. Section Abstract Doc Link 12827373 Disease Relevance 0.82 Pain Relevance 0.52
A reduced molar MMP/TIMP ratio seems to be a hallmark of pulmonary fibrosis, distinguishing it from other reversible interstitial lung diseases [26] and from chronic obstructive pulmonary disease (COPD) [29].
Negative_regulation (reduced) of TIMP in lung associated with fibrosis, interstitial lung diseases, pulmonary disease and pulmonary fibrosis
6) Confidence 0.35 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.71 Pain Relevance 0.27
Determination of IL-6, TIMP-1 and pro-MMP9 levels in BAL
Negative_regulation (Determination) of TIMP
7) Confidence 0.35 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0 Pain Relevance 0.03
Among those, MMP2 and its inhibitor TIMP1 are known to be involved in tumor progression and extracellular matrix degradation [37].
Negative_regulation (inhibitor) of TIMP1 in extracellular matrix associated with cancer
8) Confidence 0.34 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504036 Disease Relevance 0.93 Pain Relevance 0.08
OBJECTIVES: This study sought to determine the optimal daily intake, ratios, and formulation of dietary GLA and EPA required to safely reduce leukotriene biosynthesis in healthy individuals, and to evaluate the pharmacokinetics and safety profile of such a formulation.
Negative_regulation (reduce) of EPA
9) Confidence 0.34 Published 2003 Journal Clin Ther Section Body Doc Link 12852710 Disease Relevance 0.09 Pain Relevance 0
Metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPS) play key roles in extracellular matrix remodeling and degradation.
Negative_regulation (inhibitors) of metalloproteinases in extracellular matrix associated with metalloproteinase
10) Confidence 0.33 Published 2003 Journal Histochem. Cell Biol. Section Abstract Doc Link 12827373 Disease Relevance 0.81 Pain Relevance 0.52
Association of metalloproteinases, tissue inhibitors of matrix metalloproteinases, and proteoglycans with development, aging, and osteoarthritis processes in mouse temporomandibular joint.
Negative_regulation (inhibitors) of metalloproteinases in temporomandibular joint associated with snapping jaw, aging, metalloproteinase and osteoarthritis
11) Confidence 0.33 Published 2003 Journal Histochem. Cell Biol. Section Title Doc Link 12827373 Disease Relevance 1.04 Pain Relevance 0.65
Association of metalloproteinases, tissue inhibitors of matrix metalloproteinases, and proteoglycans with development, aging, and osteoarthritis processes in mouse temporomandibular joint.
Negative_regulation (inhibitors) of metalloproteinases in temporomandibular joint associated with snapping jaw, aging, metalloproteinase and osteoarthritis
12) Confidence 0.33 Published 2003 Journal Histochem. Cell Biol. Section Title Doc Link 12827373 Disease Relevance 1.03 Pain Relevance 0.62
Reduced TIMP-1 levels may also accelerate hepatocyte proliferation following partial hepatectomy, illustrating its inhibitory role in hepatocyte regeneration [41].
Negative_regulation (Reduced) of TIMP-1 in hepatocyte
13) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.18 Pain Relevance 0.46
In our study, inflammation was significantly decreased by TACE inhibition while downregulation of TIMP-1 may have further improved hepatic regeneration, as reflected by the marked decrease in serum levels of alkaline phosphatase and ALT.
Negative_regulation (downregulation) of TIMP-1 associated with inflammation
14) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 1.11 Pain Relevance 0.39
In the present study, we measured the expression of MMP-9 and tissue inhibitor of metalloproteinase-1 (TIMP-1), an inhibitor of MMP-9, in the sera and culture supernatants of dermal fibroblasts from SSc patients and compared them with serum concentrations of transforming growth factor ?
Negative_regulation (inhibitor) of TIMP in fibroblasts associated with metalloproteinase and systemic sclerosis
15) Confidence 0.31 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064883 Disease Relevance 1.39 Pain Relevance 0.41
TIMP: tissue inhibitor of metalloproteinase
Negative_regulation (inhibitor) of TIMP associated with metalloproteinase
16) Confidence 0.31 Published 2005 Journal Respir Res Section Body Doc Link PMC548519 Disease Relevance 0.69 Pain Relevance 0.32
Eicosapentaenoic acid (EPA) is one representative of the ?
Negative_regulation (representative) of EPA
17) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 1.45 Pain Relevance 0.36
In the EPA-treated animals, retinal MCP-1 (76.6±23.6 pg/mg total protein, n=7) was significantly decreased by 48.2% at 24 h after LPS injection, compared to the vehicle-treated EIU animals (148±10.2 pg/mg, n=6, p<0.05; Figure 3A).
Negative_regulation (decreased) of EPA associated with uveitis
18) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.86 Pain Relevance 0.13
In contrast, protein levels of MCP-1 in the RPE-choroid complex were significantly decreased by 31.9% in the EPA-treated animals (353.3±36.2 pg/mg, n=8, p<0.05; Figure 4A).
Negative_regulation (decreased) of EPA in choroid
19) Confidence 0.28 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2905642 Disease Relevance 0.89 Pain Relevance 0.08
EPA and COX inhibitor suppressed the expression of Bcl-2 in HL-60 cells, corporately [11].
Negative_regulation (inhibitor) of EPA in HL-60
20) Confidence 0.24 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2533717 Disease Relevance 1.05 Pain Relevance 0.13

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