INT59454

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Context Info
Confidence 0.52
First Reported 1993
Last Reported 2010
Negated 2
Speculated 3
Reported most in Body
Documents 22
Total Number 28
Disease Relevance 19.67
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (CSF2) extracellular region (CSF2)
Anatomy Link Frequency
blood 8
plasma 2
liver 2
CSF 2
puncture 2
CSF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 3 99.92 Very High Very High Very High
Multiple sclerosis 126 98.80 Very High Very High Very High
rheumatoid arthritis 56 96.00 Very High Very High Very High
Osteoarthritis 2 95.48 Very High Very High Very High
positron emission tomography 10 94.24 High High
chemokine 60 91.56 High High
cva 142 91.36 High High
Inflammatory response 12 90.84 High High
Dynorphin 2 89.64 High High
headache 35 88.68 High High
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 482 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 446 100.00 Very High Very High Very High
Infection 387 100.00 Very High Very High Very High
Cirrhosis 12 100.00 Very High Very High Very High
Disease Progression 132 99.76 Very High Very High Very High
Alzheimer's Dementia 88 99.76 Very High Very High Very High
Cognitive Disorder 231 99.60 Very High Very High Very High
Sleep Disorders 139 99.60 Very High Very High Very High
Lumbar Puncture Related Headaches 39 99.56 Very High Very High Very High
Disease 841 99.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As such, shunt treatment response depends on each individual's capacity for CSF production and absorption.
Regulation (depends) of Gene_expression (production) of CSF
1) Confidence 0.52 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2615740 Disease Relevance 1.02 Pain Relevance 0.04
Considering that 50 mL of CSF is produced in a day in humans at a rate of approximately 0.35 mL/min, 20 mL of CSF can be removed by lumbar puncture is replenished in one hour, provided there is no persistent CSF loss through the dural puncture site or alteration in CSF production caused by lumbar puncture.
Regulation (alteration) of Gene_expression (production) of CSF in puncture associated with lumbar puncture related headaches
2) Confidence 0.51 Published 2010 Journal Annals of Indian Academy of Neurology Section Body Doc Link PMC2859586 Disease Relevance 1.06 Pain Relevance 0.45
A promising approach to increase diagnostic accuracy is the use of the CSF biomarkers ?
Regulation (use) of Gene_expression (biomarkers) of CSF
3) Confidence 0.38 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2615740 Disease Relevance 0.70 Pain Relevance 0
Change in the character of CSF infection with disease progression
Regulation (Change) of Gene_expression (infection) of CSF associated with disease progression and infection
4) Confidence 0.38 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 1.02 Pain Relevance 0
Effect of treatment of CSF infection in the presence of drug resistance
Regulation (Effect) of Gene_expression (infection) of CSF associated with infection
5) Confidence 0.38 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1299327 Disease Relevance 0.75 Pain Relevance 0.03
Steven Katz had previously demonstrated the somatostatin receptors 1 and 2 in normal human choroid plexus and arachnoid granulations and thus surmised that somatostatin is involved in CSF production and egress.
Regulation (involved) of Gene_expression (production) of CSF in granulations associated with somatostatin
6) Confidence 0.38 Published 2008 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2531074 Disease Relevance 0.66 Pain Relevance 0.39
The absence of a relationship between CSF and plasma cystatin C levels suggests that this protein is independently regulated in both biofluid pools, and that plasma cystatin C is unlikely to be directly influenced by CSF levels.


Regulation (influenced) of Gene_expression (levels) of CSF in plasma
7) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.62 Pain Relevance 0
We further studied the effects of Lido on the priming of canine granulocyte CD11b expression and ROS production by recombinant canine granulocyte macrophage colony stimulating factor (rcGM-CSF).
Regulation (effects) of Gene_expression (production) of recombinant canine granulocyte macrophage colony stimulating factor in granulocyte
8) Confidence 0.31 Published 2010 Journal J. Vet. Med. Sci. Section Abstract Doc Link 19940395 Disease Relevance 0.09 Pain Relevance 0.24
0.537), but both measures of CSF cystatin C levels showed a direct correlation, with the results for total cystatin C almost reaching statistical significance (total cystatin C: Spearman r?
Regulation (measures) of Gene_expression (levels) of CSF
9) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0 Pain Relevance 0
These results indicate that CSF cystatin C levels in ALS patients change over time in a clinically-relevant manner and that increasing cystatin C concentration may be associated with slower disease progression.
Regulation (change) of Gene_expression (levels) of CSF associated with disease progression and motor neuron diseases
10) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.68 Pain Relevance 0
However, genes that regulate neutrophil function, such as those for IL-8, 47-kDa autosomal granulomatous disease protein, DNA-binding protein A variant (which regulates GM-CSF production), and cathepsin D, a potent neutrophil collagenase found to be highly expressed in the synovium of JRA, RA, and osteoarthritis patients [37-39], were identified by HV gene analysis and not by identification of genes that are up- or down-regulated in patients or controls.
Regulation (regulates) of Gene_expression (production) of GM-CSF in synovium associated with rheumatoid arthritis, disease and osteoarthritis
11) Confidence 0.29 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400410 Disease Relevance 1.10 Pain Relevance 0.17
Both factors may influence the CSF FGG levels and thereby may cause the differences seen between AD and controls.
Spec (may) Regulation (influence) of Gene_expression (levels) of CSF associated with disease
12) Confidence 0.28 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1896177 Disease Relevance 1.79 Pain Relevance 0
Identification of a novel candidate protein whose expression in CSF is altered relative to normal controls
Regulation (altered) of Gene_expression (expression) of CSF
13) Confidence 0.28 Published 2007 Journal BMC Neurol Section Body Doc Link PMC1896177 Disease Relevance 0.71 Pain Relevance 0
Thus, whereas the increases in blood and CSF levels of neopterin were of similar magnitude in the neuroasymptomatics (for example, mean CSF and blood levels of patients with <50 CD4+ cells/?
Regulation (mean) of Gene_expression (levels) of CSF in blood
14) Confidence 0.28 Published 2010 Journal AIDS Res Ther Section Body Doc Link PMC2890504 Disease Relevance 0.60 Pain Relevance 0.12
Consequently, such histological changes might influence the ability to produce active G-CSF.
Spec (might) Regulation (influence) of Gene_expression (produce) of G-CSF
15) Confidence 0.24 Published 2008 Journal World J Surg Oncol Section Body Doc Link PMC2474610 Disease Relevance 1.61 Pain Relevance 0
The effects of two different preparations of human recombinant GM-CSF, ie, glycosylated GM-CSF as expressed in a Chinese hamster ovary carcinoma (CHO) cell line and nonglycosylated GM-CSF obtained from Escherichia coli, were compared.
Regulation (effects) of Gene_expression (expressed) of GM-CSF in ovary associated with ovarian cancer
16) Confidence 0.24 Published 1993 Journal Blood Section Abstract Doc Link 8386025 Disease Relevance 0.47 Pain Relevance 0
To explore the relationship between CSF cystatin C levels measured by these two techniques, we compared our ELISA results with SELDI-TOF-MS data for the same CSF samples.
Regulation (measured) of Gene_expression (levels) of CSF
17) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000338 Disease Relevance 0.67 Pain Relevance 0
Here we report that average gelsolin concentrations in CSF collected from patients diagnosed with MS was lower (2.9 ± 1.8 versus 4.1 ± 1.7 ?
Regulation (collected) of Gene_expression (concentrations) of CSF associated with multiple sclerosis
18) Confidence 0.21 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.77 Pain Relevance 0.35
Briefly, CSF samples were subjected to centrifugation (13,500 × g, 4°C, for 20 min.), then 20 ?
Regulation (subjected) of Gene_expression (samples) of CSF
19) Confidence 0.21 Published 2010 Journal BMC Neurol Section Body Doc Link PMC2989318 Disease Relevance 0.19 Pain Relevance 0.05
As there is also evidence for altered levels of CSF Ubiquitin in AD [57–59] and vascular dementia [60], it seems that this observation is related to neurodegenerative processes in general and not to a specific disease.
Regulation (altered) of Gene_expression (levels) of CSF associated with vascular dementia, neurodegenerative disease and disease
20) Confidence 0.19 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.82 Pain Relevance 0

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