INT59465

Context Info Confidence 0.49 First Reported 1993 Last Reported 2011 Negated 1 Speculated 0 Reported most in Abstract Documents 41 Total Number 41 Disease Relevance 21.90 Pain Relevance 9.46

isomerase activity (ISYNA1) cytoplasm (ISYNA1)

Anatomy Link Frequency macrophages 3 monocytes 2 plasma 1 CGCs 1 white blood cells 1 ISYNA1 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 17 99.84 cINOD 11 99.60 opioid receptor 4 99.60 antinociception 2 99.60 cva 10 99.52 Inflammation 228 99.18 Pain 31 98.92 Migraine 15 98.84 metalloproteinase 7 98.84 Morphine 8 98.70

Disease Link Frequency Relevance Heat Infection 289 99.92 Stress 193 99.82 Cv General 3 Under Development 8 99.52 INFLAMMATION 283 99.18 Pain 27 98.92 Headache 23 98.84 Shock 26 98.80 Death 28 98.52 Injury 138 98.40 Sepsis 49 98.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The objective of this study was to investigate the pharmacodynamics and pharmacokinetics of a single dose of GW273629, a selective iNOS inhibitor, given during and outside a migraine attack.

Negative_regulation (inhibitor) of iNOS associated with migraine

1) Confidence 0.49 Published 2009 Journal J Clin Pharmacol Section Abstract Doc Link 19246728 Disease Relevance 0.27 Pain Relevance 0.27

Infection of adherent PBMLs and treatment with an iNOS inhibitor

Negative_regulation (inhibitor) of iNOS associated with infection

2) Confidence 0.43 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.44 Pain Relevance 0

Thus, the inhibition of iNOS facilitates DENV-1 replication, suggesting that NO production might be involved in the control of virus replication.

Negative_regulation (inhibition) of iNOS

3) Confidence 0.43 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.44 Pain Relevance 0

Does the unfavorable pharmacokinetic and pharmacodynamic profile of the iNOS inhibitor GW273629 lead to inefficacy in acute migraine?

Negative_regulation (inhibitor) of iNOS associated with migraine

4) Confidence 0.36 Published 2009 Journal J Clin Pharmacol Section Title Doc Link 19246728 Disease Relevance 0.40 Pain Relevance 0.51

The animals were divided into two groups: a MEG group [iNOS was inhibited with mercaptoethylguanidine (MEG), a selective inhibitor of iNOS, n=6] and a control group (n=6).

Negative_regulation (inhibitor) of iNOS

5) Confidence 0.33 Published 2001 Journal Burns Section Abstract Doc Link 11718983 Disease Relevance 0.84 Pain Relevance 0.21

The animals were divided into two groups: a MEG group [iNOS was inhibited with mercaptoethylguanidine (MEG), a selective inhibitor of iNOS, n=6] and a control group (n=6).

Negative_regulation (inhibited) of iNOS

6) Confidence 0.33 Published 2001 Journal Burns Section Abstract Doc Link 11718983 Disease Relevance 0.78 Pain Relevance 0.18

In some experiments the iNOS inhibitor, NG-methyl L-Arginine (NGMLA), was added at a final concentration of 400 ?

Negative_regulation (inhibitor) of iNOS

7) Confidence 0.32 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.48 Pain Relevance 0

DENV-1 was susceptible to a NO donor treatment and, in addition, virus was detected at higher rates in infected cells after iNOS inhibition, indicating that NO might play a substantial role in controlling DENV-1 infection of monocytes in culture and in vivo during natural infection.

Negative_regulation (inhibition) of iNOS in monocytes associated with infection

8) Confidence 0.32 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 1.32 Pain Relevance 0.19

Equivalent data was obtained with in vitro infected monocytes from healthy individuals, and virus presence can be modulated by inhibiting iNOS or generating NO in cell culture, indicating that this molecule is likely to have a role in controlling DENV-1 genome expression within monocytes.

Negative_regulation (inhibiting) of iNOS in monocytes

9) Confidence 0.32 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.78 Pain Relevance 0

DENV-Ag detection in infected cells after treatment with an iNOS inhibitor – NGMLA or with a NO donor – SNP

Negative_regulation (inhibitor) of iNOS

10) Confidence 0.32 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.22 Pain Relevance 0

Stimulation of differentiated PC12 cells with Abeta (1-42) (1 microg/mL) for 36 h caused a significant increase of nitrite production, compared to un-stimulated cells, that was inhibited in a concentration-dependent manner by both the non-selective iNOS inhibitor, L-NAME (0.3-30 microM), and, at higher extent, by the selective iNOS inhibitor SMT (0.3-30 microM).

Negative_regulation (inhibitor) of iNOS associated with abeta

11) Confidence 0.31 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16490313 Disease Relevance 0.65 Pain Relevance 0.38

Preincubation of ECs with morphine or anandamide before, but not after, the addition of LPS + IFN, blocked iNOS activity.

Negative_regulation (blocked) of iNOS in ECs associated with morphine

12) Confidence 0.29 Published 1998 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 9641464 Disease Relevance 0.06 Pain Relevance 0.63

Spermine did not affect the up-regulation of iNOS mRNA levels but in a concentration-dependent manner significantly attenuated iNOS protein levels and NO production.

Neg (NO) Negative_regulation (attenuated) of iNOS

13) Confidence 0.18 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15548540 Disease Relevance 0.28 Pain Relevance 0.04

NSAIDs have been shown to down-regulate iNOS.

Negative_regulation (down-regulate) of iNOS associated with cinod

14) Confidence 0.18 Published 2003 Journal Clin. Sci. Section Abstract Doc Link 12882643 Disease Relevance 0.68 Pain Relevance 0.58

The maximal effect of PT resulted in an 80% reduction in the formation of [3H]IPs.

Negative_regulation (reduction) of IPs

15) Confidence 0.17 Published 1993 Journal J. Endocrinol. Section Abstract Doc Link 8386215 Disease Relevance 0.23 Pain Relevance 0.09

Reduction in iNOS protein was due to inhibition of iNOS translation and not due to iNOS degradation.

Negative_regulation (Reduction) of iNOS

16) Confidence 0.16 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15548540 Disease Relevance 0.28 Pain Relevance 0.03

RT-PCR analyses indicated that AFW reduced iNOS and COX-2 mRNA without affecting the mRNA of ?

Negative_regulation (reduced) of iNOS

17) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846352 Disease Relevance 0.25 Pain Relevance 0.13

acute inhibition of iNOS is beneficial in reducing several

Negative_regulation (inhibition) of iNOS

18) Confidence 0.15 Published 2004 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC555773 Disease Relevance 0.56 Pain Relevance 0.11

This reduced tumoricidal capacity has been linked to reduced iNOS expression [48] and would be in keeping with the current data.

Negative_regulation (reduced) of iNOS

19) Confidence 0.14 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017541 Disease Relevance 1.43 Pain Relevance 0.27

Furthermore, treatment with C-1 led to a decrease in iNOS protein and mRNA.

Negative_regulation (decrease) of iNOS

20) Confidence 0.13 Published 2001 Journal Biochem. Pharmacol. Section Abstract Doc Link 11274976 Disease Relevance 0.21 Pain Relevance 0.17

General Comments

This test has worked.