INT59466

Context Info Confidence 0.77 First Reported 1993 Last Reported 2011 Negated 12 Speculated 4 Reported most in Body Documents 204 Total Number 213 Disease Relevance 112.57 Pain Relevance 35.48

isomerase activity (ISYNA1) cytoplasm (ISYNA1)

Anatomy Link Frequency macrophages 14 monocytes 12 astrocytes 5 neuronal 5 platelets 4 ISYNA1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 1726 100.00 tolerance 39 100.00 cytokine 803 99.82 cva 54 99.68 addiction 8 99.62 Multiple sclerosis 244 99.60 qutenza 19 99.54 antagonist 47 99.52 Abeta 8 99.52 Morphine 24 99.50

Disease Link Frequency Relevance Heat INFLAMMATION 2195 100.00 Familial Dysautonomia 242 100.00 Ocular Motility Disorders 54 100.00 Ophthalmoplegia 46 100.00 Adenoma 216 99.98 Stress 1706 99.96 Dengue 681 99.96 Infection 1086 99.92 Apoptosis 460 99.80 Disease 950 99.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The inducible isoform of nitric oxide synthase (iNOS) may be expressed early in the inflammatory process.

Gene_expression (expressed) of iNOS associated with inflammation

1) Confidence 0.77 Published 2003 Journal J. Rheumatol. Section Abstract Doc Link 14677189 Disease Relevance 0.46 Pain Relevance 0.45

Improvement of gastritis is expressed not only in quantity but also in quality of gastritis, which is shown as the reduction of iNOS expression in the gastric mucosa.

Gene_expression (expression) of iNOS associated with gastritis

2) Confidence 0.68 Published 2003 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 12925154 Disease Relevance 0.83 Pain Relevance 0.21

Intraepithelial lymphocyte infiltration was increased in both duodenum and colon in AS patients compared to controls. iNOS activity in duodenum and colon and expression of iNOS protein in lamina propria inflammatory cells was increased in AS patients compared to controls.

Gene_expression (expression) of iNOS in colon

3) Confidence 0.67 Published 2003 Journal J. Rheumatol. Section Body Doc Link 14677189 Disease Relevance 0.18 Pain Relevance 0

Adherent human PBMLs were incubated for 3–6 days with infectious and inactivated DENV and evaluated for presence of DENV-Ag and iNOS expression.

Gene_expression (expression) of iNOS

4) Confidence 0.66 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.39 Pain Relevance 0

INOS expression, present in a significant frequency among dengue patients, could not be associated with severity in this sampling.

Gene_expression (expression) of INOS associated with dengue

5) Confidence 0.66 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.61 Pain Relevance 0

INOS was specifically expressed in monocytes infected with DENV.

Gene_expression (expressed) of INOS in monocytes

6) Confidence 0.66 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.69 Pain Relevance 0

Characterization of target cells for DENV and iNOS expression in peripheral blood mononuclear leukocytes (PBMLs) originating from patients with Dengue Fever

Gene_expression (expression) of iNOS in leukocytes associated with dengue

7) Confidence 0.66 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.24 Pain Relevance 0

Local anesthetics decrease the production of NO by inhibiting iNOS expression in macrophages and increase NO production in glial cells.

Gene_expression (expression) of iNOS in glial cells associated with local anesthetic

8) Confidence 0.64 Published 2008 Journal J Anesth Section Abstract Doc Link 18500613 Disease Relevance 0.60 Pain Relevance 0.27

The bioavailability of NO and the activity and expression of iNOS are regulated by anesthetic agents.

Gene_expression (expression) of iNOS associated with bioavailability

9) Confidence 0.64 Published 2008 Journal J Anesth Section Abstract Doc Link 18500613 Disease Relevance 0.44 Pain Relevance 0.25

CBD (10(-6) to 10(-4) M) inhibited both nitrite production and iNOS protein expression induced by Abeta (1-42).

Gene_expression (expression) of iNOS associated with abeta

10) Confidence 0.64 Published 2006 Journal Neurosci. Lett. Section Abstract Doc Link 16490313 Disease Relevance 0.62 Pain Relevance 0.36

Nitric oxide (NO), when produced via inducible NO synthase (iNOS) in excess under pathological conditions (e.g., inflammation, endotoxemia, and septic shock), may lead to tissue injury and organ dysfunction.

Gene_expression (produced) of iNOS associated with endotoxemia, inflammation, injury and sepsis

11) Confidence 0.64 Published 2008 Journal J Anesth Section Abstract Doc Link 18500613 Disease Relevance 0.39 Pain Relevance 0.19

Cyclooxygenase-2 (COX-2), inducible NO synthase (iNOS) and IL-1beta gene expressions were quantified by transcription of mRNA followed by real time and quantitative polymerase chain reaction.

Gene_expression (expressions) of iNOS

12) Confidence 0.62 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0.08 Pain Relevance 0

RESULTS: LPS markedly increased the expression of IL-1beta, iNOS and COX-2 genes.

Gene_expression (expression) of iNOS

13) Confidence 0.62 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0.07 Pain Relevance 0

L-NMMA did not significantly affect the expression of IL-1beta, iNOS and COX-2.

Gene_expression (expression) of iNOS

14) Confidence 0.62 Published 2002 Journal Osteoarthr. Cartil. Section Body Doc Link 12127835 Disease Relevance 0 Pain Relevance 0

Sodium nitroprusside, an NO donor as well, also increases iNOS expression.

Gene_expression (expression) of iNOS

15) Confidence 0.62 Published 2002 Journal Ann. Neurol. Section Abstract Doc Link 11921057 Disease Relevance 0.45 Pain Relevance 0.31

This study tested the hypothesis that nitric oxide (NO) synthesized from inducible NO synthase (iNOS) is responsible for the cardiac dysfunction observed after burn and smoke inhalation injury.

Gene_expression (synthesized) of iNOS associated with smoke inhalation injury and burns

16) Confidence 0.59 Published 2001 Journal Burns Section Abstract Doc Link 11718983 Disease Relevance 0.62 Pain Relevance 0.16

Lymphocytic infiltration in the lamina propria and intraepithelial infiltration were quantified by histological score. iNOS expression was assessed by immunohistochemistry with monoclonal antibodies, and iNOS activity was determined by radiochemical assay.

Gene_expression (expression) of iNOS in lamina

17) Confidence 0.59 Published 2003 Journal J. Rheumatol. Section Body Doc Link 14677189 Disease Relevance 0.25 Pain Relevance 0

INOS is apparently detected in cells already at day 3, but it reaches significantly higher frequencies of positive cells at days 5 and 6 (Figure 4E).

Gene_expression (detected) of INOS

18) Confidence 0.58 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.25 Pain Relevance 0

Among 22 patients tested for iNOS expression (Figures 1H and 2B), 10 were positive as compared to controls (Figures 1G and 2B).

Gene_expression (expression) of iNOS

19) Confidence 0.58 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.63 Pain Relevance 0

Representative dot plots of DENV Antigens (Ag) and iNOS positive detection in monocytes from dengue patients (Figures 1E and 1H, respectively) are compared to monocytes from healthy individuals (Figures 1D and 1G) and lymphocytes from patients (Figures 1F and 1I).

Gene_expression (detection) of iNOS in lymphocytes associated with dengue

20) Confidence 0.58 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1208887 Disease Relevance 0.54 Pain Relevance 0

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