INT59473

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Context Info
Confidence 0.25
First Reported 1993
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.33
Pain Relevance 1.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
molecular_function (Col1a1) cytoplasm (Col1a1)
Anatomy Link Frequency
stellate cell 1
neurons 1
Col1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 6 98.86 Very High Very High Very High
methotrexate 55 98.42 Very High Very High Very High
Dopamine 4 87.80 High High
fibrosis 15 86.08 High High
agonist 1 81.64 Quite High
Inflammation 32 75.48 Quite High
cytokine 20 69.04 Quite High
tolerance 1 64.80 Quite High
addiction 1 63.68 Quite High
Inflammatory response 4 31.52 Quite Low
Disease Link Frequency Relevance Heat
Vibrio Infection 1 96.16 Very High Very High Very High
Intervertebral Disk Degeneration 39 88.96 High High
Cardiovascular Disorder Under Development 7 86.08 High High
INFLAMMATION 38 75.48 Quite High
Obesity 2 75.44 Quite High
Ventricular Remodeling 6 72.96 Quite High
Heart Rate Under Development 20 71.08 Quite High
Disease 37 62.24 Quite High
Scheuermann's Disease 1 57.92 Quite High
Dilated Cardiomyopathy 7 54.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taurine chloramine decreased type I collagen, transforming growth factor-beta1, and matrix metalloproteinases 2 of the pancreatic stellate cell culture supernatant.
Negative_regulation (decreased) of type I collagen in stellate cell
1) Confidence 0.25 Published 2008 Journal J. Gastroenterol. Hepatol. Section Body Doc Link 17764527 Disease Relevance 0 Pain Relevance 0
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Negative_regulation (level) of COLIA1
2) Confidence 0.18 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.70 Pain Relevance 0
In this study, we observed that MTX treatment not only significantly reduced the deposition of collagens but also decreased the collagen type I/III ratio, suggesting a beneficial role of antifibrosis and cardiac function.
Negative_regulation (decreased) of collagen type I associated with methotrexate
3) Confidence 0.10 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 0.54 Pain Relevance 0.49
In morphine-treated neurons, the number of inhibitory G-proteins (G alpha i) appeared to be slightly reduced (by about 16%).
Negative_regulation (reduced) of alpha i in neurons associated with morphine
4) Confidence 0.01 Published 1993 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8386668 Disease Relevance 0.10 Pain Relevance 0.74

General Comments

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