INT5948

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Context Info
Confidence 0.60
First Reported 1991
Last Reported 2010
Negated 7
Speculated 16
Reported most in Abstract
Documents 44
Total Number 60
Disease Relevance 22.80
Pain Relevance 25.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1b) aging (Il1b) extracellular region (Il1b)
Anatomy Link Frequency
brain 5
spinal cord 4
blood 3
astrocytes 3
vagus nerve 2
Il1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 89 100.00 Very High Very High Very High
Opioid 54 100.00 Very High Very High Very High
Inflammation 36 100.00 Very High Very High Very High
antagonist 22 100.00 Very High Very High Very High
narcan 19 100.00 Very High Very High Very High
Hyperalgesia 18 100.00 Very High Very High Very High
Enkephalin 17 100.00 Very High Very High Very High
Inflammatory response 16 100.00 Very High Very High Very High
Pain 14 100.00 Very High Very High Very High
anesthesia 13 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 57 100.00 Very High Very High Very High
Hyperalgesia 24 100.00 Very High Very High Very High
Neuropathic Pain 21 100.00 Very High Very High Very High
Rheumatoid Arthritis 3 100.00 Very High Very High Very High
Cancer 37 99.92 Very High Very High Very High
Pain 10 99.80 Very High Very High Very High
Necrosis 36 99.68 Very High Very High Very High
Eating Disorder 14 99.64 Very High Very High Very High
Temporomandibular Joint Syndrome 1 99.58 Very High Very High Very High
Nociception 11 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Serum and local TNF-alpha levels were suppressed in treated animals whereas there were little changes in interleukin-1beta levels.
Neg (little) Regulation (changes) of interleukin-1beta
1) Confidence 0.60 Published 2000 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10884526 Disease Relevance 1.18 Pain Relevance 0.77
This study aimed to determine the effect of sirolimus on hyperalgesia and allodynia and on serum and spinal cord TNF-alpha, IL-1beta and IL-6 levels in rat neuropathic pain.
Spec (determine) Regulation (effect) of IL-1beta in spinal cord associated with hyperalgesia, allodynia, neuropathic pain and spinal cord
2) Confidence 0.60 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20600616 Disease Relevance 1.16 Pain Relevance 1.24
Interestingly, the inhibition of the ERK pathway suppressed the development of tolerance and morphine-induced up-regulation of IL-1beta, TNF-alpha, and mPGES-1.
Regulation (regulation) of IL-1beta associated with tolerance and morphine
3) Confidence 0.60 Published 2009 Journal FASEB J. Section Abstract Doc Link 19299480 Disease Relevance 0.06 Pain Relevance 1.76
The enhanced mu-receptor mRNA expression, together with the previous observation that IL1 beta stimulates proenkephalin synthesis in astrocytes, supports the IL1 beta-mediated regulation of an astroglial opioid peptide and receptor in vitro, a phenomenon that may be significant in the modulation of the gliotic response to neuronal damage.
Regulation (regulation) of IL1 beta in astrocytes associated with opioid
4) Confidence 0.46 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8522984 Disease Relevance 0 Pain Relevance 0.47
To characterize more completely the astrocytic opioid response to immune factor stimulation, we examined the effect of IL1 beta (1 ng/ml) on the mu-receptor mRNA expression in primary astrocyte-enriched cultures derived from rat (postnatal day 1-2) cortex, striatum, cerebellum, hippocampus, and hypothalamus.
Spec (examined) Regulation (effect) of IL1 beta in hypothalamus associated with hippocampus and opioid
5) Confidence 0.46 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8522984 Disease Relevance 0 Pain Relevance 0.47
The effect of intraportal administrations of interleukin 1 beta (IL-1 beta) on the afferent activity of the hepatic branch of the vagus nerve was observed in urethane anesthetized rats.
Regulation (effect) of interleukin 1 beta in vagus nerve associated with vagus nerve
6) Confidence 0.45 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8988487 Disease Relevance 0 Pain Relevance 0.05
The effect of intraportal administrations of interleukin 1 beta (IL-1 beta) on the afferent activity of the hepatic branch of the vagus nerve was observed in urethane anesthetized rats.
Regulation (effect) of IL-1 beta in vagus nerve associated with vagus nerve
7) Confidence 0.45 Published 1996 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 8988487 Disease Relevance 0 Pain Relevance 0.05
Responses of 42 neurosecretory neurons in the supraoptic nucleus (SON) to human recombinant interleukin-1 beta (IL-1 beta) were examined during intracellular recordings in rat brain slices.
Spec (examined) Regulation (Responses) of IL-1 beta in brain
8) Confidence 0.45 Published 1992 Journal Neuroreport Section Abstract Doc Link 1319228 Disease Relevance 0 Pain Relevance 0.07
The inhibition of evoked overflow by IL-1 beta was not affected by indomethacin but was reduced or even prevented in the presence of NNA or naloxone, or after lymphocyte depletion of spleens by CY.
Neg (not) Regulation (affected) of IL-1 beta in spleens associated with narcan
9) Confidence 0.45 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7630433 Disease Relevance 0 Pain Relevance 0.74
In phenobarbitone-anesthetized rats the effects of interleukin 1 beta (IL-1 beta) and tumor necrosis factors (TNFs) were examined on the capsaicin-induced increase of plantar cutaneous blood flow in the rat hind paw as measured by laser Doppler flowmetry.
Regulation (effects) of IL-1 beta in blood associated with necrosis, qutenza and cancer
10) Confidence 0.45 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846404 Disease Relevance 0.55 Pain Relevance 0.22
In phenobarbitone-anesthetized rats the effects of interleukin 1 beta (IL-1 beta) and tumor necrosis factors (TNFs) were examined on the capsaicin-induced increase of plantar cutaneous blood flow in the rat hind paw as measured by laser Doppler flowmetry.
Regulation (effects) of interleukin 1 beta in blood associated with necrosis, qutenza and cancer
11) Confidence 0.45 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 8846404 Disease Relevance 0.55 Pain Relevance 0.22
The effects of interleukin-1 beta on the mechanical nociceptive threshold in rat were examined using the paw-pressure test.
Regulation (effects) of interleukin-1 beta in paw associated with nociception
12) Confidence 0.45 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8741165 Disease Relevance 0.38 Pain Relevance 0.35
Although rhIL-1 beta (100 pg, i.v.) produced a fall in arterial blood pressure, baroreceptor denervation did not affect the excitatory responses of the adrenal and splenic nerves to rhIL-1 beta.
Neg (not) Regulation (responses) of rhIL-1 beta in blood
13) Confidence 0.45 Published 1991 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1787257 Disease Relevance 0 Pain Relevance 0
The effects of intravenous (i.v.) administration of recombinant human interleukin-1 beta (rhIL-1 beta) on the activity of adrenal, splenic and renal sympathetic nerves were observed in urethane-anesthetized rats.
Regulation (effects) of rhIL-1 beta in sympathetic
14) Confidence 0.45 Published 1991 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 1787257 Disease Relevance 0 Pain Relevance 0
The effects of interleukin-1 beta on the activity of adrenal, splenic and renal sympathetic nerves in the rat.
Regulation (effects) of interleukin-1 beta in nerves associated with anesthesia
15) Confidence 0.45 Published 1991 Journal J. Auton. Nerv. Syst. Section Title Doc Link 1787257 Disease Relevance 0 Pain Relevance 0.10
Because levels of the cytokine interleukin-1 beta (IL-1 beta) increase following CNS lesions, we examined the possible influence of IL-1 beta on the expression of opioid genes in astrocytes cultured from rat cortex.
Spec (possible) Regulation (influence) of IL-1 beta in cortex associated with central nervous system, opioid and cytokine
16) Confidence 0.44 Published 1992 Journal Glia Section Abstract Doc Link 1478730 Disease Relevance 0.27 Pain Relevance 0.49
The present studies examined the effects of chronic interleukin-1 (IL-1 beta) infusion on glucose homeostasis and insulin secretion in male Sprague Dawley rats.
Spec (examined) Regulation (effects) of IL-1 beta
17) Confidence 0.44 Published 1994 Journal Life Sci. Section Abstract Doc Link 8295488 Disease Relevance 0.19 Pain Relevance 0.08
Recent work in our laboratory has demonstrated that the mu-opioid receptor is involved in interleukin-1beta (IL-1beta)- and in lipopolysaccharide (LPS)-induced fevers.
Regulation (involved) of interleukin-1beta associated with opioid receptor and fever
18) Confidence 0.44 Published 2002 Journal Life Sci. Section Abstract Doc Link 12002806 Disease Relevance 0.35 Pain Relevance 0.32
Effects of an interleukin-1beta analogue [Lys-D-Pro-Thr], on incomplete cerebral ischemia-induced inhibition of long-term potentiation in rat hippocampal neurons in vivo.
Regulation (Effects) of interleukin-1beta in neurons associated with anesthesia, cv general 4 under development, ischemia and long-term potentiation
19) Confidence 0.44 Published 1999 Journal Neurosci. Lett. Section Title Doc Link 10081976 Disease Relevance 0.99 Pain Relevance 0.58
Naloxone (5 mg/kg i.v.) did not affect the oxytocin secretory response to IL-1beta in virgin rats, whereas in late pregnant rats naloxone revealed a greater oxytocin secretory response to IL-1beta (3.5-fold) than in virgin rats.
Neg (not) Regulation (affect) of IL-1beta associated with narcan
20) Confidence 0.44 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16553786 Disease Relevance 0.06 Pain Relevance 0.67

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