INT59531

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 1.31
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Trh) plasma membrane (Trh) nucleus (Trh)
cytoplasm (Trh)
Anatomy Link Frequency
striatum 4
habenulae 3
hippocampus 3
hypothalamus 1
medial geniculate nucleus 1
Trh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 141 100.00 Very High Very High Very High
Central nervous system 4 100.00 Very High Very High Very High
Serotonin 5 99.76 Very High Very High Very High
substance P 3 99.48 Very High Very High Very High
Thalamus 2 98.12 Very High Very High Very High
Hippocampus 8 98.04 Very High Very High Very High
amygdala 4 97.80 Very High Very High Very High
Substantia nigra 29 92.72 High High
Spinal cord 4 90.88 High High
Neurotransmitter 2 89.96 High High
Disease Link Frequency Relevance Heat
Dyskinesias 102 97.52 Very High Very High Very High
Urological Neuroanatomy 8 97.28 Very High Very High Very High
Disease 63 86.56 High High
Body Weight 2 83.96 Quite High
Alcohol Addiction 2 67.00 Quite High
Congenital Anomalies 9 57.28 Quite High
Parkinson's Disease 18 50.00 Quite Low
Hyperkinesis 15 5.00 Very Low Very Low Very Low
Tremor 6 5.00 Very Low Very Low Very Low
Thyroid Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to the very restricted mRNA expression of TRH-R1 in the central nervous system, TRH-R2 mRNA was widely distributed with highest transcript levels throughout the thalamus, in the cerebral and cerebellar cortex, medial habenulae, medial geniculate nucleus, pontine nuclei, and throughout the reticular formation.
Positive_regulation (distributed) of Transcription (expression) of TRH in habenulae associated with thalamus and central nervous system
1) Confidence 0.69 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 11064370 Disease Relevance 0 Pain Relevance 0.25
The levels of preproTRH mRNA were significantly increased in the dopamine-depleted striatum of the rats that developed dyskinesia in response to the L-DOPA treatment (mixed design analysis of variance [ANOVA]; Treatment × Side interaction: F1,31?
Positive_regulation (increased) of Transcription (levels) of preproTRH in striatum associated with dopamine and dyskinesias
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.10 Pain Relevance 0.21
PreproTRH mRNA levels in the dopamine-depleted striatum of the L-DOPA-treated animals were positively correlated with the behavioral scores (Pearson's r ?
Positive_regulation (striatum) of Transcription (levels) of PreproTRH in striatum associated with dopamine
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.14 Pain Relevance 0.17
Both preproTRH mRNA and TRH peptide levels were increased, and these increases were selective for the combination of 6-OHDA-induced dopamine depletion and L-DOPA treatment.
Positive_regulation (increased) of Transcription (levels) of preproTRH associated with dopamine
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2978093 Disease Relevance 0.09 Pain Relevance 0.24
ProTRH mRNA levels increased at 1 h post-injection in total hypothalamus and hippocampus, while they decreased in the frontal cortex.
Positive_regulation (increased) of Transcription (levels) of ProTRH in hippocampus associated with urological neuroanatomy and hippocampus
5) Confidence 0.47 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871700 Disease Relevance 0.49 Pain Relevance 0.36
In contrast to the very restricted mRNA expression of TRH-R1 in the central nervous system, TRH-R2 mRNA was widely distributed with highest transcript levels throughout the thalamus, in the cerebral and cerebellar cortex, medial habenulae, medial geniculate nucleus, pontine nuclei, and throughout the reticular formation.
Positive_regulation (distributed) of in medial geniculate nucleus Transcription (expression) of TRH in habenulae associated with thalamus and central nervous system
6) Confidence 0.24 Published 2000 Journal J. Comp. Neurol. Section Abstract Doc Link 11064370 Disease Relevance 0 Pain Relevance 0.25
Just like the mRNA coding for the precursor of SP (preprotachykinin, PPT), levels of TRH mRNA are increased when serotonin synthesis is inhibited by para-chlorophenylalanine (pCPA) and decreased when serotonin reuptake is blocked by zimelidine.
Positive_regulation (increased) of Transcription (levels) of TRH associated with serotonin and substance p
7) Confidence 0.20 Published 1993 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8389958 Disease Relevance 0 Pain Relevance 0.58
ProTRH mRNA levels increased at 1 h post-injection in total hypothalamus and hippocampus, while they decreased in the frontal cortex.
Positive_regulation (increased) of in hypothalamus Transcription (levels) of ProTRH in hippocampus associated with urological neuroanatomy and hippocampus
8) Confidence 0.16 Published 2000 Journal Neurochem. Int. Section Abstract Doc Link 10871700 Disease Relevance 0.49 Pain Relevance 0.36

General Comments

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