INT59540

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Context Info
Confidence 0.36
First Reported 1993
Last Reported 2009
Negated 0
Speculated 3
Reported most in Abstract
Documents 2
Total Number 4
Disease Relevance 2.61
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh, Gnrh1) extracellular region (Crh, Gnrh1) molecular_function (Gnrh1)
response to stress (Crh) cytoplasm (Crh)
Anatomy Link Frequency
MPOA 3
Crh (Rattus norvegicus)
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 6 94.40 High High
antagonist 16 85.28 High High
opioid receptor 6 75.00 Quite High
mu opioid receptor 3 72.36 Quite High
Acupuncture 56 54.32 Quite High
narcan 6 25.00 Low Low
Central nervous system 2 5.00 Very Low Very Low Very Low
c fibre 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 54 99.54 Very High Very High Very High
Polycystic Ovary Syndrome 62 91.92 High High
Apoptosis 1 73.12 Quite High
Metabolic Disorder 1 68.08 Quite High
Syndrome 2 66.28 Quite High
Insulin Resistance 1 65.12 Quite High
Hyperinsulinism 1 64.16 Quite High
Obesity 1 63.44 Quite High
Anovulation 1 55.20 Quite High
Hyperandrogenism 1 54.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Corticotropin-releasing hormone (CRH) may also modulate GnRH release [5] and thus may be involved in the neuroendocrine dysfunction.
CRH Spec (may) Regulation (modulate) of GnRH
1) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2722078 Disease Relevance 1.25 Pain Relevance 0.05
In order to verify whether CRF is able to directly influence luteinizing hormone-releasing hormone (LHRH) secretory activity at the level of the medial preoptic area (MPOA), CRF was chronically or acutely injected bilaterally into this hypothalamic area.
CRF Spec (whether) Regulation (influence) of luteinizing hormone-releasing hormone in MPOA associated with urological neuroanatomy
2) Confidence 0.20 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8389996 Disease Relevance 0.41 Pain Relevance 0.06
In conclusion, the present data show that from among the hypothalamic sites tested, only the MPOA proved susceptible to CRF-induced alteration of LHRH neuronal activity during proestrus afternoon in rats.
CRF Regulation (alteration) of LHRH in MPOA associated with urological neuroanatomy
3) Confidence 0.20 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8389996 Disease Relevance 0.55 Pain Relevance 0.40
In order to verify whether CRF is able to directly influence luteinizing hormone-releasing hormone (LHRH) secretory activity at the level of the medial preoptic area (MPOA), CRF was chronically or acutely injected bilaterally into this hypothalamic area.
CRF Spec (whether) Regulation (influence) of LHRH in MPOA associated with urological neuroanatomy
4) Confidence 0.20 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8389996 Disease Relevance 0.41 Pain Relevance 0.06

General Comments

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