INT59547

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Context Info
Confidence 0.14
First Reported 1993
Last Reported 2003
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.13
Pain Relevance 1.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Avp, Crh) extracellular region (Avp, Crh) response to stress (Avp, Crh)
signal transduction (Avp) cytoplasm (Crh) signal transducer activity (Avp)
Anatomy Link Frequency
adrenal glands 2
nucleus 1
Avp (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 2 97.26 Very High Very High Very High
antagonist 5 91.92 High High
agonist 12 88.12 High High
Central nervous system 38 87.96 High High
Inflammation 134 85.24 High High
Catecholamine 12 79.00 Quite High
cytokine 62 77.12 Quite High
Inflammatory mediators 4 72.48 Quite High
depression 2 69.36 Quite High
noradrenaline 2 53.32 Quite High
Disease Link Frequency Relevance Heat
Autoimmune Disease 8 86.16 High High
INFLAMMATION 142 85.24 High High
Stress 27 78.40 Quite High
Adhesions 2 76.24 Quite High
Fever 2 70.68 Quite High
Depression 2 69.36 Quite High
Cancer 4 47.92 Quite Low
Necrosis 4 47.44 Quite Low
Disease 54 34.20 Quite Low
Rheumatoid Arthritis 162 32.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Arginine vasopressin (AVP) synergistically enhances CRH-stimulated ACTH release [10,11] ACTH in turn induces the expression and release of glucocorticoids from the adrenal glands.
Arginine vasopressin Positive_regulation (enhances) of CRH in adrenal glands
1) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.53 Pain Relevance 0.50
Arginine vasopressin (AVP) synergistically enhances CRH-stimulated ACTH release [10,11] ACTH in turn induces the expression and release of glucocorticoids from the adrenal glands.
AVP Positive_regulation (enhances) of CRH in adrenal glands
2) Confidence 0.14 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC333413 Disease Relevance 0.52 Pain Relevance 0.50
Clonidine (30 micrograms/kg) attenuated CRF-41/AVP (1 pmol/10 pmol)-induced ACTH secretion in sham-operated rats, but was ineffective in reducing CRF-41/AVP-induced ACTH secretion in rats with paraventricular nucleus lesion.
AVP-induced Positive_regulation (induced) of CRF-41 in nucleus associated with clonidine
3) Confidence 0.05 Published 1993 Journal Neuroendocrinology Section Abstract Doc Link 8389998 Disease Relevance 0.08 Pain Relevance 0.47

General Comments

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