INT5957

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Context Info
Confidence 0.69
First Reported 1980
Last Reported 2008
Negated 4
Speculated 2
Reported most in Abstract
Documents 65
Total Number 67
Disease Relevance 21.07
Pain Relevance 51.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
brain 4
plasma 3
GPI 2
striatum 2
spinal cord 2
Cpe (Mus musculus)
Cpe - R6L (1)
Pain Link Frequency Relevance Heat
Enkephalin 382 100.00 Very High Very High Very High
Neuropeptide 39 100.00 Very High Very High Very High
Dynorphin 36 100.00 Very High Very High Very High
opioid receptor 34 100.00 Very High Very High Very High
depression 15 100.00 Very High Very High Very High
analgesia 12 100.00 Very High Very High Very High
Raphe magnus 12 100.00 Very High Very High Very High
agonist 5 100.00 Very High Very High Very High
Kappa opioid receptor 3 100.00 Very High Very High Very High
Locus ceruleus 1 99.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Heart Rate Under Development 4 100.00 Very High Very High Very High
Sprains And Strains 198 99.98 Very High Very High Very High
Ganglion Cysts 9 99.82 Very High Very High Very High
Depression 15 99.62 Very High Very High Very High
Targeted Disruption 27 99.40 Very High Very High Very High
Disease 67 99.28 Very High Very High Very High
Alcohol Addiction 8 99.02 Very High Very High Very High
Infection 221 98.96 Very High Very High Very High
Peritonitis 2 98.80 Very High Very High Very High
Obesity 4 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cholestasis liver disease is associated with clinical and experimental findings consistent with increased opioidergic neuromodulation, increased plasma total activity, and elevated plasma enkephalin concentrations.
Positive_regulation (elevated) of enkephalin in plasma associated with liver disease, enkephalin and gallstones
1) Confidence 0.69 Published 1998 Journal Behav Pharmacol Section Abstract Doc Link 9832951 Disease Relevance 0.35 Pain Relevance 0.67
The local increase in Met-enkephalin level during zymosan-induced peritonitis may be related to its local production by exudatory leukocytes (as evidenced by our previous experiments) and influx from distal centers, as its level is significantly decreased in blood, inguinal lymph nodes, and some brain areas (striatum, hypothalamus, and pituitary gland).
Positive_regulation (increase) of Met-enkephalin in blood associated with peritonitis and enkephalin
2) Confidence 0.69 Published 2003 Journal Pol J Pharmacol Section Abstract Doc Link 14506328 Disease Relevance 0.17 Pain Relevance 0.21
However at concentrations producing an extracellular increase in enkephalin levels and subsequent analgesia, the mixed inhibitor prodrug of the enkephalin-metabolizing enzymes RB 101 (20 or 100 mg/kg i.v. and 5 or 10 mg/kg i.v., in the hot plate test and in the abdominal constriction test, respectively) did not potentiate the paradoxical analgesia induced by naloxone.
Positive_regulation (increase) of enkephalin associated with narcan, enkephalin and analgesia
3) Confidence 0.63 Published 1994 Journal Neuropharmacology Section Abstract Doc Link 7910383 Disease Relevance 0.10 Pain Relevance 1.16
It was shown that inhibition of bone marrow hyperplasia disappear due to injection of leu-enkephalin and dalargin as well as the increase of plasma leu-enkephalin by means of D-phenylalanine on the immobilized mice.
Positive_regulation (increase) of leu-enkephalin in bone marrow associated with enkephalin and hyperplasia
4) Confidence 0.59 Published 1989 Journal Biull Eksp Biol Med Section Abstract Doc Link 2804327 Disease Relevance 0.25 Pain Relevance 0.37
Met-enkephalin levels in whole brain homogenates often first paradoxically increase after a few days of ethanol drinking and then decrease with the development of physical dependence.
Positive_regulation (increase) of Met-enkephalin in brain associated with physical dependence and enkephalin
5) Confidence 0.52 Published 2006 Journal Peptides Section Abstract Doc Link 16672169 Disease Relevance 0.17 Pain Relevance 0.78
The results suggest that enkephalin actions on escape conditioning are mediated through opioid receptors.
Positive_regulation (mediated) of enkephalin associated with opioid receptor and enkephalin
6) Confidence 0.50 Published 1984 Journal Behav. Neurosci. Section Abstract Doc Link 6732926 Disease Relevance 0.26 Pain Relevance 0.80
In vivo, acute morphine in mice decreased the Met-enkephalin hydrolysis but increased the Leu-enkephalin hydrolysis.
Positive_regulation (increased) of Leu-enkephalin associated with enkephalin and morphine
7) Confidence 0.48 Published 1981 Journal Peptides Section Abstract Doc Link 7196572 Disease Relevance 0.08 Pain Relevance 1.58
In alcohol-withdrawal animals, Met-enkephalin levels remained elevated in WSP mice, whereas they increased in WSR mice.
Positive_regulation (elevated) of enkephalin associated with enkephalin, withdrawal and alcohol
8) Confidence 0.48 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11325389 Disease Relevance 0.57 Pain Relevance 1.68
In outbred mice, alcohol dependence is associated with decreased PTS-1 activity and increased levels of Met-enkephalin.
Positive_regulation (increased) of enkephalin associated with addiction, enkephalin and alcohol
9) Confidence 0.48 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11325389 Disease Relevance 0.52 Pain Relevance 1.40
The results indicate significantly decreased leu-enkephalin content and significantly increased dynorphin/enkephalin content ratios in high-stereotypy mice relative to low-stereotypy mice.
Positive_regulation (increased) of enkephalin associated with dynorphin and enkephalin
10) Confidence 0.45 Published 2005 Journal Behav. Brain Res. Section Abstract Doc Link 15639187 Disease Relevance 0.06 Pain Relevance 0.88
Furthermore, the increase in levels of high molecular weight enkephalin peptides in the Cpefat/Cpefat mouse suggests that CPE is required for efficient peptide processing by the endopeptidases.
Positive_regulation (required) of CPE associated with enkephalin
11) Confidence 0.44 Published 1996 Journal J. Biol. Chem. Section Abstract Doc Link 8940036 Disease Relevance 0 Pain Relevance 0.34
A large increase in endogenous enkephalin levels induced by RB 101, associated or not with stress, was also indirectly demonstrated by the analgesic responses elicited by i.v. injection of the mixed inhibitor.
Positive_regulation (increase) of enkephalin associated with stress, analgesic and enkephalin
12) Confidence 0.42 Published 1992 Journal Brain Res. Section Abstract Doc Link 1319268 Disease Relevance 0.19 Pain Relevance 0.93
Firstly, many DRG neurons responded to dynorphin but not to leucine-enkephalin or morphiceptin.
Neg (not) Positive_regulation (responded) of leucine-enkephalin in neurons associated with dorsal root ganglion, dynorphin and enkephalin
13) Confidence 0.39 Published 1984 Journal Neurosci. Lett. Section Abstract Doc Link 6146120 Disease Relevance 0.36 Pain Relevance 1.43
The effects of enkephalin, but not those of U-50488H, were also significantly enhanced during chronic CO.
Positive_regulation (effects) of enkephalin associated with enkephalin
14) Confidence 0.38 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9864294 Disease Relevance 0.39 Pain Relevance 0.91
If the dipeptidyl carboxypeptidase, inhibited by thiorphan, were located extraneuronally as suggested by De La Baume, Patey and Schwartz (1981), the met5-enkephalin accumulation represents the rate at which the pentapeptide is released extraneuronally.
Positive_regulation (accumulation) of met5-enkephalin associated with enkephalin
15) Confidence 0.36 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6750433 Disease Relevance 0.07 Pain Relevance 0.51
The increase in met5-enkephalin content was accompanied by an inhibition, greater than 80%, of the dipeptidyl carboxypeptidase that degrades striatal met5-enkephalin.
Positive_regulation (increase) of met5-enkephalin associated with enkephalin
16) Confidence 0.36 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6750433 Disease Relevance 0.07 Pain Relevance 0.53
Thiorphan (60 micrograms intracerebrally) increased the met5-enkephalin content of mouse striatum by 30% in 30 min.
Positive_regulation (increased) of met5-enkephalin in striatum associated with enkephalin
17) Confidence 0.36 Published 1982 Journal Neuropharmacology Section Abstract Doc Link 6750433 Disease Relevance 0.07 Pain Relevance 0.39
We measured levels of preproenkephalin (PPE) mRNA and Met-enkephalin peptide in brain and the activity of PTS-1 during alcohol-naive, -dependent, and -withdrawal states.
Positive_regulation (levels) of enkephalin in brain associated with enkephalin, withdrawal and alcohol
18) Confidence 0.34 Published 2001 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 11325389 Disease Relevance 0.60 Pain Relevance 1.60
These findings suggested that mesolimbic enkephalin is augmented following ethanol consumption, and that endogenous low enkephalin biosynthesis may be associated with an increased vulnerability for ethanol abuse.
Positive_regulation (augmented) of enkephalin associated with alcohol addiction and enkephalin
19) Confidence 0.34 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8884235 Disease Relevance 0.25 Pain Relevance 0.83
The increase of leucine enkephalin in the Wobbler spinal cord correlates significantly with age and with the progress of the disease, but leucine enkephalin declines slightly with age in the controls.
Positive_regulation (increase) of enkephalin in spinal cord associated with enkephalin, disease and spinal cord
20) Confidence 0.33 Published 1992 Journal Neuroscience Section Abstract Doc Link 1383870 Disease Relevance 0.69 Pain Relevance 1.72

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