INT59576

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 1993
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 6
Disease Relevance 2.07
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MGST1) small molecule metabolic process (MGST1) endoplasmic reticulum (MGST1)
nucleus (MGST1)
Anatomy Link Frequency
liver 2
MGST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 99.32 Very High Very High Very High
alcohol 1 97.40 Very High Very High Very High
cINOD 5 94.60 High High
COX2 5 25.00 Low Low
Paracetamol 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Colon Cancer 20 98.80 Very High Very High Very High
INFLAMMATION 5 94.40 High High
Avian Sarcoma 1 88.40 High High
Respiratory Syncytial Virus 1 86.80 High High
Cancer 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
While the ARE-specific inducer tBHQ did not modulate the basal expression of MGST1-L1, it was found to act as an antagonist of interleukin-1 beta-stimulated MGST1-L1 overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MGST1-L1 associated with antagonist
1) Confidence 0.34 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12818365 Disease Relevance 0.32 Pain Relevance 0.11
While the ARE-specific inducer tBHQ did not modulate the basal expression of MGST1-L1, it was found to act as an antagonist of interleukin-1 beta-stimulated MGST1-L1 overexpression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of MGST1-L1 associated with antagonist
2) Confidence 0.34 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12818365 Disease Relevance 0.32 Pain Relevance 0.11
We have found that these xenobiotics both down-regulate and up-regulate the expression of COX-2 and MGST1-L1.
Positive_regulation (up-regulate) of Gene_expression (expression) of MGST1-L1
3) Confidence 0.34 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12818365 Disease Relevance 0.43 Pain Relevance 0.09
Increased production of prostaglandin E(2) (PGE(2)) by the combined activities of cyclooxygenase-2 (COX-2) and microsomal glutathione S-transferase 1-like 1 (MGST1-L1) enhances the progression of colorectal cancer.
Positive_regulation (Increased) of Gene_expression (production) of MGST1-L1 associated with colon cancer
4) Confidence 0.34 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12818365 Disease Relevance 0.40 Pain Relevance 0.08
We have found that these xenobiotics both down-regulate and up-regulate the expression of COX-2 and MGST1-L1.
Positive_regulation (up-regulate) of Gene_expression (expression) of MGST1-L1
5) Confidence 0.34 Published 2003 Journal Biochem. Pharmacol. Section Abstract Doc Link 12818365 Disease Relevance 0.43 Pain Relevance 0.09
This cell line expressed cytochrome b5 (58 +/- 12 pmol/mg microsomal protein vs 528 +/- 80 pmol/mg in microsomal human liver) and a high level of NADPH: cytochrome P450 reductase (140 +/- 20 nmol.min-1.mg microsomal protein-1 vs 68 +/- 48 nmol.min-1.mg-1 in microsomal human liver).
Positive_regulation (level) of Gene_expression (expressed) of microsomal protein-1 in liver
6) Confidence 0.12 Published 1993 Journal Eur. J. Biochem. Section Abstract Doc Link 8391436 Disease Relevance 0.18 Pain Relevance 0.05

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox