INT59600

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Context Info
Confidence 0.39
First Reported 1993
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 3.63
Pain Relevance 0.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNFRSF10B)
Anatomy Link Frequency
plasma 1
TMJ 1
TNFRSF10B (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 1 94.44 High High
antagonist 1 93.92 High High
cINOD 8 82.64 Quite High
agonist 1 81.24 Quite High
diclofenac 6 77.76 Quite High
Inflammation 1 55.52 Quite High
Snapping jaw 1 50.00 Quite Low
Migraine 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 30 100.00 Very High Very High Very High
Reprotox - General 1 3 98.16 Very High Very High Very High
Apoptosis 66 96.94 Very High Very High Very High
Cancer 32 96.92 Very High Very High Very High
Necrosis 4 96.68 Very High Very High Very High
Skin Cancer 1 82.80 Quite High
INFLAMMATION 4 75.00 Quite High
Cervical Cancer 5 73.00 Quite High
Keratosis 1 65.40 Quite High
Temporomandibular Joint Syndrome 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest a possible pivotal role of the TRAIL/DR5 system in TMJ disc degeneration.


Spec (possible) Regulation (role) of DR5 in TMJ
1) Confidence 0.39 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20123409 Disease Relevance 0 Pain Relevance 0
Sulindac sulfide specifically up-regulated the DR5 levels but had no effect on the levels of other DRs including DR4, Fas, and tumor necrosis factor receptor 1.
Regulation (regulated) of DR5 associated with necrosis and cancer
2) Confidence 0.26 Published 2001 Journal Cancer Res. Section Abstract Doc Link 11559570 Disease Relevance 1.59 Pain Relevance 0.07
Progesterone may rapidly change membrane potential, and eventually function, by acting on putative NK plasma membrane receptors coupled to Na+ conductances.
Regulation (acting) of NK in plasma
3) Confidence 0.26 Published 1993 Journal Nat. Immun. Section Abstract Doc Link 8392407 Disease Relevance 0 Pain Relevance 0.18
Affymetrix microarray analysis of gene expression profiles revealed that butyrate treatment down-regulated pro-apoptotic BAD, BAX and BAK, genes associated with the mitochondrial pathway, while genes associated with the death receptor pathway, such as Fas, FasL, Trail and DR5, were basically not affected by the treatment (data not shown).
Regulation (affected) of DR5 associated with apoptosis and death
4) Confidence 0.06 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.91 Pain Relevance 0
In addition, altered lipid concentrations in the cytoplasmic membrane may modulate death receptor activities.
Regulation (modulate) of death receptor associated with death
5) Confidence 0.01 Published 2007 Journal Br. J. Dermatol. Section Abstract Doc Link 17488403 Disease Relevance 1.12 Pain Relevance 0.73

General Comments

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