INT59655

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Context Info
Confidence 0.60
First Reported 1993
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 13
Total Number 16
Disease Relevance 10.51
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc9a3) transmembrane transport (Slc9a3)
Anatomy Link Frequency
kidney 3
ascending limbs 2
brush 2
tubule 1
ovary 1
Slc9a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
bradykinin 11 95.80 Very High Very High Very High
antagonist 33 90.48 High High
Clonidine 4 70.24 Quite High
Potency 2 65.80 Quite High
addiction 2 57.28 Quite High
isoflurane 44 27.52 Quite Low
anesthesia 39 5.00 Very Low Very Low Very Low
fibrosis 11 5.00 Very Low Very Low Very Low
medulla 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 1364 99.84 Very High Very High Very High
Kidney Stones 48 99.82 Very High Very High Very High
Hypertrophy 121 95.38 Very High Very High Very High
Polyuria 11 80.60 Quite High
Uremia 44 79.60 Quite High
Body Weight 12 73.36 Quite High
Targeted Disruption 23 51.12 Quite High
Natriuresis 22 40.12 Quite Low
Disorders Of Creatine Metabolism 11 13.68 Low Low
Hypercalcemia 14 9.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Candesartan treatment significantly decreased whole kidney NHE3 expression in CRF rats (25±5% of sham-operated control level, p<0.05, Fig. 5, Table 2), whereas whole kidney NHE3 expression was unchanged in CRF rats treated with vehicle only (76±16% of sham-operated control level, n.s., Fig. 5, Table 2).
Gene_expression (expression) of NHE3 in kidney associated with chronic renal failure
1) Confidence 0.60 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.18 Pain Relevance 0
Candesartan treatment significantly decreased whole kidney NHE3 expression in CRF rats (25±5% of sham-operated control level, p<0.05, Fig. 5, Table 2), whereas whole kidney NHE3 expression was unchanged in CRF rats treated with vehicle only (76±16% of sham-operated control level, n.s., Fig. 5, Table 2).
Gene_expression (expression) of NHE3 in kidney associated with chronic renal failure
2) Confidence 0.60 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.16 Pain Relevance 0
The decreased AQP2 expression in CRF rats was not altered in response to candesartan treatment; 3) Candesartan treatment was associated with decreased NHE3 and TSC expression in CRF, which could be due to the Ang II AT1 receptor blockade and/or decreased aldosterone levels; and 4) BSC-1 expression was increased in both CRF groups and the increased expression of BSC-1 was more prominent in candesartan-treated CRF rats compared with vehicle-treated CRF rats.
Gene_expression (expression) of NHE3 associated with chronic renal failure
3) Confidence 0.60 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.28 Pain Relevance 0
Kidney expression of NHE3 and TSC was decreased in CRF rats treated with candesartan (CRF-C)
Gene_expression (expression) of NHE3 in Kidney associated with chronic renal failure
4) Confidence 0.60 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.29 Pain Relevance 0
In contrast immunoperoxidase microscopy and confocal laser scanning microscopy demonstrated that NHE3 immunolabeling in the brush border of the proximal tubules was markedly enhanced in AngII-treated rats, suggesting that high plasma AngII levels may contribute to an enhanced renal Na+ and HCO3- reabsorption in kidney tubules by increasing the abundance of NHE3 and BSC-1 in mTAL cells as well as increasing NHE3 expression in the proximal tubule brush border.
Gene_expression (expression) of NHE3 in brush
5) Confidence 0.60 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.30 Pain Relevance 0.06
In the present study, we aimed to examine the effects of AngII AT1 receptor blockade on the expression of major renal sodium transporters (NHE3, BSC-1, and TSC) and vasopressin-regulated aquaporin-2 (AQP2) in rats with an early stage of CRF induced by 5/6 nephrectomy.
Spec (examine) Gene_expression (expression) of NHE3 associated with chronic renal failure
6) Confidence 0.60 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.30 Pain Relevance 0.14
Consistent with this, the protein expression of NHE3, which is mainly localized at the apical membrane domains of the proximal tubule and plays a role in the sodium reabsorption, was significantly decreased in CRF rats treated with candesartan compared with CRF rats treated with vehicle but the GFR between the two groups was not different.
Gene_expression (expression) of NHE3 in tubule associated with chronic renal failure
7) Confidence 0.60 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.38 Pain Relevance 0
In our experiment, high calcium diet and vitamin D3 decreased protein abundance of TRPV5, NHE3, SGLT1, and NKCC2, resulting in severe hypercalciuria and the expression of TRPV5, NHE3, and NKCC2 was not restored by HCTZ administration.
Gene_expression (expression) of NHE3 associated with kidney stones
8) Confidence 0.58 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.19 Pain Relevance 0
To assess the effect of thiazides on the transporters participating in the passive and active calcium reabsorption under severe hypercalciuric condition, the expression of NHE3 and SGLT1 on the PT, NKCC2 on the TAL, and TRPV5 and calbindin-D28K on the DCT was analyzed.


Spec (analyzed) Gene_expression (expression) of NHE3
9) Confidence 0.58 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.28 Pain Relevance 0
To examine some of their functional properties, full-length cDNAs for two of these isoforms, rat NHE-1 and NHE-3, were stably transfected in Na/H exchanger-deficient Chinese hamster ovary cells (AP-1) and assayed for transport activity by measuring amiloride-inhibitable H(+)-activated 22Na+ influx.
Gene_expression (transfected) of NHE-3 in ovary
10) Confidence 0.55 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8393860 Disease Relevance 0 Pain Relevance 0.15
In contrast immunoperoxidase microscopy and confocal laser scanning microscopy demonstrated that NHE3 immunolabeling in the brush border of the proximal tubules was markedly enhanced in AngII-treated rats, suggesting that high plasma AngII levels may contribute to an enhanced renal Na+ and HCO3- reabsorption in kidney tubules by increasing the abundance of NHE3 and BSC-1 in mTAL cells as well as increasing NHE3 expression in the proximal tubule brush border.
Gene_expression (immunolabeling) of NHE3 in brush
11) Confidence 0.52 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.34 Pain Relevance 0
Heterologous expression and functional properties of amiloride high affinity (NHE-1) and low affinity (NHE-3) isoforms of the rat Na/H exchanger.
Gene_expression (expression) of NHE-3
12) Confidence 0.49 Published 1993 Journal J. Biol. Chem. Section Title Doc Link 8393860 Disease Relevance 0 Pain Relevance 0.20
In conclusion, 1) candesartan treatment in an early phase of CRF is associated with decreased renal hypertrophy and increased BUN level; 2) decreased AQP2 level in CRF is likely to play a role in the decreased urine concentration, and the downregulation is not altered in response to candesartan treatment; 3) candesartan treatment decreases NHE3 and TSC expression; and 4) an increase of BSC-1 is prominent in candesartan-treated CRF rats, which could be associated with the increased delivery of sodium and water to the thick ascending limb.



Gene_expression (expression) of NHE3 in ascending limb associated with hypertrophy and chronic renal failure
13) Confidence 0.46 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2808601 Disease Relevance 1.49 Pain Relevance 0
In contrast, the expression of NHE3 (25%) and TSC (27%) was decreased in CRF-C, whereas no changes were observed in CRF-V.
Gene_expression (expression) of NHE3 associated with chronic renal failure
14) Confidence 0.46 Published 2005 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2808601 Disease Relevance 1.89 Pain Relevance 0
We have previously demonstrated that chronic infusion of supraphysiological doses of AngII in normal rats was associated with significantly increased abundance and apical expression level of the Na-H exchanger NHE3 and Na-K-2Cl cotransporter BSC-1 in medullary thick ascending limbs (mTAL), whereas Na,K-ATPase and electroneutral Na-HCO3 cotransporter (NBCn1) levels remained unchanged (10).
Gene_expression (expression) of Na-H exchanger NHE3 in ascending limbs
15) Confidence 0.46 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.31 Pain Relevance 0
Expression of NHE3, SGLT1, and NKCC2 mRNA was significantly decreased in the high Ca-vitamin D group, which increased when HCTZ was administered. mRNA expression results are summarized in Table 3.


Gene_expression (Expression) of NHE3
16) Confidence 0.45 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.13 Pain Relevance 0

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