INT59657

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Context Info
Confidence 0.53
First Reported 1993
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.17
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Slc9a3) transmembrane transport (Slc9a3)
Anatomy Link Frequency
brush 6
kidney 2
ovary 2
Slc9a3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 2 68.16 Quite High
antagonist 12 61.04 Quite High
Potency 1 59.28 Quite High
bradykinin 4 46.00 Quite Low
addiction 1 42.24 Quite Low
isoflurane 16 5.00 Very Low Very Low Very Low
anesthesia 12 5.00 Very Low Very Low Very Low
fibrosis 4 5.00 Very Low Very Low Very Low
medulla 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chronic Renal Failure 496 99.84 Very High Very High Very High
Hypertrophy 44 90.40 High High
Natriuresis 8 22.92 Low Low
Uremia 16 5.00 Very Low Very Low Very Low
Fibrosis 4 5.00 Very Low Very Low Very Low
Disorders Of Creatine Metabolism 4 5.00 Very Low Very Low Very Low
Bartter Syndrome 4 5.00 Very Low Very Low Very Low
Hypercalcemia 4 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 4 5.00 Very Low Very Low Very Low
Targeted Disruption 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast immunoperoxidase microscopy and confocal laser scanning microscopy demonstrated that NHE3 immunolabeling in the brush border of the proximal tubules was markedly enhanced in AngII-treated rats, suggesting that high plasma AngII levels may contribute to an enhanced renal Na+ and HCO3- reabsorption in kidney tubules by increasing the abundance of NHE3 and BSC-1 in mTAL cells as well as increasing NHE3 expression in the proximal tubule brush border.
Positive_regulation (increasing) of Gene_expression (expression) of NHE3 in brush
1) Confidence 0.53 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.30 Pain Relevance 0.06
To examine some of their functional properties, full-length cDNAs for two of these isoforms, rat NHE-1 and NHE-3, were stably transfected in Na/H exchanger-deficient Chinese hamster ovary cells (AP-1) and assayed for transport activity by measuring amiloride-inhibitable H(+)-activated 22Na+ influx.
Positive_regulation (transfected) of Gene_expression (transfected) of NHE-3 in ovary
2) Confidence 0.41 Published 1993 Journal J. Biol. Chem. Section Abstract Doc Link 8393860 Disease Relevance 0 Pain Relevance 0.15
In contrast immunoperoxidase microscopy and confocal laser scanning microscopy demonstrated that NHE3 immunolabeling in the brush border of the proximal tubules was markedly enhanced in AngII-treated rats, suggesting that high plasma AngII levels may contribute to an enhanced renal Na+ and HCO3- reabsorption in kidney tubules by increasing the abundance of NHE3 and BSC-1 in mTAL cells as well as increasing NHE3 expression in the proximal tubule brush border.
Positive_regulation (enhanced) of Gene_expression (immunolabeling) of NHE3 in brush
3) Confidence 0.39 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.35 Pain Relevance 0
In contrast immunoperoxidase microscopy and confocal laser scanning microscopy demonstrated that NHE3 immunolabeling in the brush border of the proximal tubules was markedly enhanced in AngII-treated rats, suggesting that high plasma AngII levels may contribute to an enhanced renal Na+ and HCO3- reabsorption in kidney tubules by increasing the abundance of NHE3 and BSC-1 in mTAL cells as well as increasing NHE3 expression in the proximal tubule brush border.
Positive_regulation (increasing) of Gene_expression (expression) of NHE3 in brush
4) Confidence 0.39 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 0.36 Pain Relevance 0.06
Candesartan treatment significantly decreased whole kidney NHE3 expression in CRF rats (25±5% of sham-operated control level, p<0.05, Fig. 5, Table 2), whereas whole kidney NHE3 expression was unchanged in CRF rats treated with vehicle only (76±16% of sham-operated control level, n.s., Fig. 5, Table 2).
Neg (unchanged) Positive_regulation (unchanged) of Gene_expression (expression) of NHE3 in kidney associated with chronic renal failure
5) Confidence 0.36 Published 2005 Journal Journal of Korean Medical Science Section Body Doc Link PMC2808601 Disease Relevance 1.16 Pain Relevance 0

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