INT5966

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 50
Total Number 50
Disease Relevance 22.91
Pain Relevance 26.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
monocytes 3
microglia 3
macrophages 2
brain 2
PVN 2
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 507 100.00 Very High Very High Very High
cytokine 378 100.00 Very High Very High Very High
Glutamate 59 100.00 Very High Very High Very High
Dopamine 47 100.00 Very High Very High Very High
Enkephalin 19 99.86 Very High Very High Very High
dexamethasone 56 99.84 Very High Very High Very High
Hyperalgesia 166 99.76 Very High Very High Very High
noradrenaline 8 99.76 Very High Very High Very High
gABA 64 99.72 Very High Very High Very High
diclofenac 2 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 555 100.00 Very High Very High Very High
Cancer 69 100.00 Very High Very High Very High
Necrosis 28 100.00 Very High Very High Very High
Hyperalgesia 179 99.76 Very High Very High Very High
Pain 133 99.24 Very High Very High Very High
Nervous System Injury 62 99.20 Very High Very High Very High
Rheumatoid Arthritis 113 99.02 Very High Very High Very High
Peptic Ulcer 2 99.00 Very High Very High Very High
Disease 74 98.92 Very High Very High Very High
Ganglion Cysts 12 98.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Following nerve injury, spinal cord glia become activated and secrete a number of inflammatory cytokines, including interleukin-1 (IL-1), which exists as two genetically distinct proteins, IL-1alpha and IL-1beta.
Localization (secrete) of IL-1alpha in spinal cord associated with nervous system injury, inflammation, cytokine and spinal cord
1) Confidence 0.78 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19341730 Disease Relevance 0.59 Pain Relevance 0.91
Treatment in vivo with the NSAID Na-diclofenac lowered PGE2 and IL-1 release and partly reversed the observed reduction of class I and II antigens.
Localization (release) of IL-1 in PGE2 associated with cinod and diclofenac
2) Confidence 0.76 Published 1990 Journal Agents Actions Section Abstract Doc Link 2327311 Disease Relevance 0.16 Pain Relevance 0.15
Similar results were previously found after the injection of bacterial lipopolysaccharide, which induces the release of IL-1 from macrophages.
Localization (release) of IL-1 in macrophages
3) Confidence 0.75 Published 1992 Journal Endocrinology Section Abstract Doc Link 1319322 Disease Relevance 0.16 Pain Relevance 0.11
Over a 4-day period, the specific sites of release of IL-1alpha and IL-1beta in the brain were elucidated by immunocytochemistry with double- labeling.
Localization (release) of IL-1alpha in brain
4) Confidence 0.73 Published 2005 Journal J. Neurotrauma Section Abstract Doc Link 16083355 Disease Relevance 1.02 Pain Relevance 0.20
Using rat peritoneal macrophages and blood monocytes we examined the relationship of developing adjuvant disease (AD) with the expression of class I and II antigens, release of interleukin-1 (IL-1) and production of prostaglandin E2 (PGE2).
Localization (release) of IL-1 in monocytes associated with disease
5) Confidence 0.71 Published 1990 Journal Agents Actions Section Abstract Doc Link 2327311 Disease Relevance 0.17 Pain Relevance 0.12
After a single dose of IL-1, 4 micrograms/kg, i. p., basal acid secretion was almost completely inhibited for 4 hours in conscious chronic gastric fistula rats.
Localization (secretion) of IL-1 associated with gastric fistula
6) Confidence 0.69 Published 1993 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 8518422 Disease Relevance 0.85 Pain Relevance 0.16
AIM: To localize interleukin-1 receptor type I (IL-1RI) in rat dental pulp and trigeminal ganglion (TG) and to test the hypothesis that pulpal inflammation increases neuronal expression of IL-1RI.
Localization (localize) of IL-1RI in dental pulp associated with ganglion cysts, inflammation and trigeminal ganglion
7) Confidence 0.66 Published 2009 Journal Int Endod J Section Abstract Doc Link 19732182 Disease Relevance 0.42 Pain Relevance 0.25
CONCLUSIONS: The localization of IL-1RI on sensory nerve fibres and its up-regulation in TG neurons during pulpal inflammation may imply a direct effect of IL-1 in pulpal nociception.
Localization (localization) of IL-1RI in neurons
8) Confidence 0.66 Published 2009 Journal Int Endod J Section Body Doc Link 19732182 Disease Relevance 0.11 Pain Relevance 0
The presence of IL-1RI on sympathetic nerve fibres and on blood vessels may indicate a vasoactive role of the same cytokine in the pulp.


Localization (presence) of IL-1RI in sympathetic
9) Confidence 0.58 Published 2009 Journal Int Endod J Section Body Doc Link 19732182 Disease Relevance 0 Pain Relevance 0
The present study determined the time course and localization of alterations in circulating and tissue pro-inflammatory cytokines (TNF-alpha, IL-1-alpha and -beta) in response to fixed-pressure (40 mm Hg) hemorrhage as well as the associated hanges in circulating neurohormonal and opioid mediators.
Localization (localization) of IL-1-alpha associated with inflammation, cva, opioid and cytokine
10) Confidence 0.54 Published 1997 Journal Neuroimmunomodulation Section Abstract Doc Link 9326742 Disease Relevance 0.68 Pain Relevance 0.64
This conclusion is based on our finding that intravenous injection of IL-1 increases CRF biosynthesis in the PVN, and that lesion of this hypothalamic area interferes with IL-1's stimulatory action on ACTH secretion.
Localization (secretion) of IL-1 in PVN
11) Confidence 0.54 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491087 Disease Relevance 0 Pain Relevance 0.18
Because neither CRF antagonists, nor lesions of the PVN, alter the inhibitory effect of IL-1 on LH release, CRF perikarya in the PVN do not appear to be involved in this phenomenon.
Localization (release) of IL-1 in PVN associated with antagonist
12) Confidence 0.54 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491087 Disease Relevance 0 Pain Relevance 0.18
The release of CRF or IL-1 elicited by EA may trigger the release of opioid peptides within inflamed tissue which may activate peripheral opioid receptors and inhibit the pain.
Localization (release) of IL-1 associated with pain, opioid receptor, opioid and electroacupuncture
13) Confidence 0.53 Published 2004 Journal Am. J. Chin. Med. Section Abstract Doc Link 15315264 Disease Relevance 0.50 Pain Relevance 1.07
Spinal glial activation and consequent interleukin-1 (IL-1) release are implicated in pain facilitation induced by inflammation/damage to skin and peripheral nerves.
Localization (release) of IL-1 in peripheral nerves associated with pain, inflammation and glial activation
14) Confidence 0.52 Published 2006 Journal J Pain Section Abstract Doc Link 17018336 Disease Relevance 0.57 Pain Relevance 0.78
Infusion of IL-1 beta into the PVN does not induce measurable changes in release of gonadotropin-releasing hormone (GnRH), but infusion of IL-1 directly into the median preoptic area (MPOA), a region rich in GnRH perikarya, markedly decreases GnRH secretion in rats bearing a push-pull cannula in the median eminence.
Localization (secretion) of IL-1 in MPOA
15) Confidence 0.51 Published 1993 Journal Ciba Found. Symp. Section Abstract Doc Link 8491087 Disease Relevance 0 Pain Relevance 0.20
DEX slightly inhibited IL-1-induced IL-6 release, while IL-1 releasing action on IL-6 was significantly reduced by IND.
Localization (releasing) of IL-1 associated with dexamethasone
16) Confidence 0.34 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
To rule out the possibility that DEX was inhibiting LPS-induced IL-6 release by blocking IL-6 gene expression, we tested the effect of DEX on interleukin 1beta(IL-1)-induced IL-6 release.
Localization (release) of IL-1 associated with dexamethasone
17) Confidence 0.30 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
DEX slightly inhibited IL-1-induced IL-6 release, while IL-1 releasing action on IL-6 was significantly reduced by IND.
Localization (release) of IL-1-induced associated with dexamethasone
18) Confidence 0.30 Published 1998 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9784426 Disease Relevance 0.07 Pain Relevance 0.32
Both END and DYN, but not MET, were released by IL-1.
Localization (released) of IL-1 associated with enkephalin
19) Confidence 0.30 Published 2001 Journal Pain Section Abstract Doc Link 11514079 Disease Relevance 0.37 Pain Relevance 1.83
Following nerve injury, spinal cord glia become activated and secrete a number of inflammatory cytokines, including interleukin-1 (IL-1), which exists as two genetically distinct proteins, IL-1alpha and IL-1beta.
Localization (secrete) of IL-1 in spinal cord associated with nervous system injury, inflammation, cytokine and spinal cord
20) Confidence 0.29 Published 2009 Journal Exp. Neurol. Section Abstract Doc Link 19341730 Disease Relevance 0.53 Pain Relevance 0.88

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