INT59663

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Context Info
Confidence 0.58
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.22
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a6) enzyme binding (Ugt1a6) protein complex (Ugt1a6)
Anatomy Link Frequency
SON 2
Ugt1a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cINOD 2 99.84 Very High Very High Very High
adenocard 163 99.68 Very High Very High Very High
noradrenaline 7 99.46 Very High Very High Very High
antagonist 10 98.92 Very High Very High Very High
dexamethasone 2 98.84 Very High Very High Very High
depression 6 94.72 High High
agonist 3 93.84 High High
Clonidine 1 93.20 High High
Inflammatory mediators 2 87.60 High High
medulla 2 86.16 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 14 99.64 Very High Very High Very High
Depression 6 94.72 High High
Convulsion 2 22.64 Low Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Epilepsy 1 5.00 Very Low Very Low Very Low
Anaerobic Bacterial Infections 1 5.00 Very Low Very Low Very Low
Hypercapnia 1 5.00 Very Low Very Low Very Low
Cv Unclassified Under Development 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, this endotoxin-induced increase in UGT1A6 expression level was blocked by actinomycin D and cycloheximide, indicating the requirement for RNA and protein synthesis.
Negative_regulation (blocked) of Positive_regulation (increase) of UGT1A6
1) Confidence 0.58 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.49 Pain Relevance 0.36
The UGT1A6 expression enhancement could be prevented by anti-inflammatory drugs (dexamethasone and NS398) or nitric oxide synthase inhibitors (L-NAME and L-NMMA).
Negative_regulation (prevented) of Positive_regulation (enhancement) of UGT1A6 associated with inflammation, cinod and dexamethasone
2) Confidence 0.42 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.48 Pain Relevance 0.38
Initial experiments done in pentobarbitone anaesthetized rats established that SON application of NA excited VP cells but also depressed their response to activation of the A1 input.
Negative_regulation (depressed) of Positive_regulation (activation) of A1 in SON associated with noradrenaline
3) Confidence 0.33 Published 1993 Journal Brain Res. Section Abstract Doc Link 8394178 Disease Relevance 0 Pain Relevance 0.47
This inhibition was produced by the release of adenosine (presumably from a component within or activated by the stimulated pathway) and the subsequent activation of presynaptic A1 receptors (as the inhibition could be blocked by the adenosine receptor antagonist theophylline).
Negative_regulation (blocked) of Positive_regulation (activation) of A1 associated with adenocard and antagonist
4) Confidence 0.03 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701281 Disease Relevance 0.24 Pain Relevance 0.62

General Comments

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