INT59665

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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 24
Disease Relevance 7.24
Pain Relevance 13.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt1a6) enzyme binding (Ugt1a6) protein complex (Ugt1a6)
Anatomy Link Frequency
ileum 2
synapses 2
liver 1
SON 1
dorsal horn 1
Ugt1a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 862 100.00 Very High Very High Very High
Inflammation 90 100.00 Very High Very High Very High
agonist 116 99.50 Very High Very High Very High
antinociception 4 99.20 Very High Very High Very High
Lasting pain 10 99.12 Very High Very High Very High
cINOD 7 99.08 Very High Very High Very High
noradrenaline 16 98.90 Very High Very High Very High
Antinociceptive 26 98.84 Very High Very High Very High
Dorsal horn 6 98.84 Very High Very High Very High
hypoalgesia 4 98.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 106 99.52 Very High Very High Very High
Pain 52 99.12 Very High Very High Very High
Injury 26 98.60 Very High Very High Very High
Hypoalagesia 4 98.56 Very High Very High Very High
Nociception 45 98.44 Very High Very High Very High
Neuropathic Pain 82 98.00 Very High Very High Very High
Nerve Compression Syndromes 90 97.52 Very High Very High Very High
Depression 26 92.28 High High
Targeted Disruption 12 91.68 High High
Increased Venous Pressure Under Development 5 77.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, this endotoxin-induced increase in UGT1A6 expression level was blocked by actinomycin D and cycloheximide, indicating the requirement for RNA and protein synthesis.
Positive_regulation (increase) of UGT1A6
1) Confidence 0.69 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.49 Pain Relevance 0.36
This increase in glucuronidation activity was associated with an up-regulation of the UGT1A6 isoform mRNA level as shown by RT-PCR and gene reporter assay.
Positive_regulation (up-regulation) of UGT1A6
2) Confidence 0.69 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.50 Pain Relevance 0.33
Induction of UGT1A6 isoform by inflammatory conditions in rat astrocytes.
Positive_regulation (Induction) of UGT1A6 in astrocytes associated with inflammation
3) Confidence 0.69 Published 2006 Journal Neuropharmacology Section Title Doc Link 16274708 Disease Relevance 0.51 Pain Relevance 0.41
Messenger RNA and protein levels of UGT1A1 and UGT1A6 in the liver but not the jejunum were increased in male rats fed the HF1 diet.
Positive_regulation (increased) of UGT1A6 in jejunum
4) Confidence 0.60 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.11
We propose, based on the data presented, that the action of LPS to induce UGT1A6 isoform up-regulation may be mediated by pro-inflammatory mediator accumulation, and AP-1 binding activity increase.
Positive_regulation (up-regulation) of UGT1A6 associated with inflammation
5) Confidence 0.50 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.52 Pain Relevance 0.35
The UGT1A6 expression enhancement could be prevented by anti-inflammatory drugs (dexamethasone and NS398) or nitric oxide synthase inhibitors (L-NAME and L-NMMA).
Positive_regulation (enhancement) of UGT1A6 associated with inflammation, cinod and dexamethasone
6) Confidence 0.50 Published 2006 Journal Neuropharmacology Section Abstract Doc Link 16274708 Disease Relevance 0.48 Pain Relevance 0.38
One mechanism by which PFAAs may deplete T4 is through induction of the hepatic uridine diphosphoglucuronosyl transferase (UGT) system, which is involved in hepatic metabolism of thyroid hormone and biliary clearance of T4 as T4-glucuronide (Barter and Klaassen 1994).
Positive_regulation (induction) of UGT in thyroid
7) Confidence 0.49 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2866686 Disease Relevance 0.09 Pain Relevance 0.13
Additionally, administration of the PPARalpha agonist clofibrate to male rats up-regulated UGT1A1 and UGT1A6 and down-regulated CYP1A2 in the liver.
Positive_regulation (up-regulated) of UGT1A6 in liver associated with agonist
8) Confidence 0.43 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 17967931 Disease Relevance 0 Pain Relevance 0.30
Further studies showed that yohimbine also prevented the relative decline in synaptic excitation of VP cells normally observed as A1 activation frequency increases.
Positive_regulation (increases) of A1
9) Confidence 0.39 Published 1993 Journal Brain Res. Section Abstract Doc Link 8394178 Disease Relevance 0 Pain Relevance 0.46
Initial experiments done in pentobarbitone anaesthetized rats established that SON application of NA excited VP cells but also depressed their response to activation of the A1 input.
Positive_regulation (activation) of A1 in SON associated with noradrenaline
10) Confidence 0.36 Published 1993 Journal Brain Res. Section Abstract Doc Link 8394178 Disease Relevance 0 Pain Relevance 0.47
There has been evidences that activation of the A1 and A2 receptors produce an antinociceptive effect, while activation of the A3 receptor produce nociception [17].
Positive_regulation (activation) of A1 associated with nociception and antinociceptive
11) Confidence 0.29 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC56902 Disease Relevance 0.29 Pain Relevance 0.85
Henceforth the AE antinociceptive effect at the formalin test second phase may be associated to an activation of the A1 and/or A2 adenosine receptors.
Positive_regulation (activation) of A1 associated with adenocard and antinociceptive
12) Confidence 0.25 Published 2001 Journal BMC Pharmacol Section Body Doc Link PMC56902 Disease Relevance 0.37 Pain Relevance 1.07
A1 receptors in the rat ileum are known to be situated on cholinergic nerve endings innervating the smooth muscle, and activation of these A1 receptors reduces smooth-muscle contraction following electrical stimulation, by reducing acetylcholine (ACH) release [9-12].
Positive_regulation (activation) of A1 in ileum
13) Confidence 0.20 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139982 Disease Relevance 0 Pain Relevance 0.35
Thus, these results suggest that activation of adenosine A1 receptors are required for the synergistic interaction between gabapentin and R-PIA in reducing mechanical allodynia.



Positive_regulation (activation) of A1 associated with adenocard, allodynia and gabapentin
14) Confidence 0.20 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526387 Disease Relevance 0.41 Pain Relevance 1.02
Previous studies demonstrated that both A1 and A2 receptor subtypes are concentrated in a very small area of the dorsal horn and are only localized diffusely throughout the ventral horn (20).
Positive_regulation (concentrated) of A1 in dorsal horn associated with dorsal horn
15) Confidence 0.16 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2526387 Disease Relevance 0.42 Pain Relevance 1.47
There is abundant evidence that increasing central inhibition by activating adenosine A1, GABAA or GABAB receptors produces hypoalgesia in acute pain tests [29], [30].
Positive_regulation (activating) of A1 associated with adenocard, acute pain and hypoalgesia
16) Confidence 0.15 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2796387 Disease Relevance 0.96 Pain Relevance 1.04
This finding is different compared to studies focused on the peristaltic reflex and peristalsis, in which activation of A1 receptors causes an attenuation of the ascending contraction in guinea-pig ileum [30] or a decrease in peristalsis in rat jejunum [31] but direct comparison in this case is hampered by the different setups, different species and the different and higher agonist concentration used.
Positive_regulation (activation) of A1 in ileum associated with agonist
17) Confidence 0.14 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139982 Disease Relevance 0.08 Pain Relevance 0.25
Since in the present experimental set-up, the A1 receptor antagonist DPCPX when given alone also attenuates the myenteric reflex responses, these data suggest that activation of A1 receptors by endogenously released adenosine under our experimental conditions stimulates the myenteric reflex responses.
Positive_regulation (activation) of A1 associated with adenocard and antagonist
18) Confidence 0.14 Published 2002 Journal BMC Neurosci Section Body Doc Link PMC139982 Disease Relevance 0 Pain Relevance 0.27
A1 and A3R activation usually results in antinociception and decreased neuropathic pain symptoms, whereas A2A and A2BR activation promotes nociception [10,28].
Positive_regulation (activation) of A1 associated with nociception, antinociception and neuropathic pain
19) Confidence 0.11 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 0.81 Pain Relevance 1.06
We hypothesized that the differential SNE effects on basal and evoked ATP release could result from the conversion of extracellular ATP to adenosine with subsequent activation of adenosine A1 receptors (A1Rs) on DRG neurons.
Positive_regulation (activation) of A1 in neurons associated with adenocard and nerve compression syndromes
20) Confidence 0.10 Published 2008 Journal Mol Pain Section Abstract Doc Link PMC2630978 Disease Relevance 0.84 Pain Relevance 0.40

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