INT59674

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Context Info
Confidence 0.47
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 2.12
Pain Relevance 3.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Chrna6) plasma membrane (Chrna6)
Anatomy Link Frequency
neuronal 2
spinal 1
forebrain 1
oocytes 1
Chrna6 (Mus musculus)
Pain Link Frequency Relevance Heat
GABAergic 20 100.00 Very High Very High Very High
Pain 14 100.00 Very High Very High Very High
local anesthetic 4 99.98 Very High Very High Very High
Dopamine 13 99.84 Very High Very High Very High
intrathecal 6 99.56 Very High Very High Very High
Hippocampus 9 99.36 Very High Very High Very High
Cannabinoid receptor 1 99.00 Very High Very High Very High
Limbic system 2 98.88 Very High Very High Very High
Nicotine 58 98.36 Very High Very High Very High
GABA receptor 11 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Low Back Pain 7 100.00 Very High Very High Very High
Disease 8 97.40 Very High Very High Very High
Dementia 2 96.92 Very High Very High Very High
INFLAMMATION 2 91.24 High High
Pain 8 90.04 High High
Targeted Disruption 13 86.08 High High
Ganglion Cysts 35 83.92 Quite High
Nociception 19 83.40 Quite High
Neuropathic Pain 9 82.64 Quite High
Aging 5 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of three barbiturates and the local anesthetic procaine on the ion channel function of mouse nicotinic acetylcholine receptor (nAChR) muscle subtype expressed in Xenopus laevis oocytes were examined by whole-cell voltage-clamp technique. 2.
Gene_expression (expressed) of nAChR in oocytes associated with local anesthetic
1) Confidence 0.47 Published 1993 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8394216 Disease Relevance 0 Pain Relevance 0.21
These electrophysiologic studies provide further evidence that barbiturates and local anesthetics produce inhibition of the nAChR at different sites.
Gene_expression (produce) of nAChR associated with local anesthetic
2) Confidence 0.41 Published 1993 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 8394216 Disease Relevance 0 Pain Relevance 0.20
Age-related changes in the mammalian dorsal hippocampus are associated with diminished expression of neuronal nicotinic acetylcholine receptors (nAChR), which is particularly severe in pathologies such as those associated with dementias, including Alzheimer's disease.
Gene_expression (expression) of nAChR in neuronal associated with dementia, hippocampus and disease
3) Confidence 0.38 Published 2005 Journal J. Neurobiol. Section Abstract Doc Link 15551346 Disease Relevance 0.33 Pain Relevance 0.29
Because the mouse is a useful model for age-related decline in nAChR expression in the basal forebrain and limbic system, we used immunohistochemistry to examine the influence of long-term (12-month) oral administration of nicotine and/or the cyclooxygenase-2 (COX-2) preferring non-steroidal anti-inflammatory drug (NSAID) NS398 on nAChR alpha4, alpha5, alpha7, and beta4 expression in the C57BL/6 mouse.
Gene_expression (expression) of nAChR in forebrain associated with inflammation, nicotine, cinod and limbic system
4) Confidence 0.29 Published 2005 Journal J. Neurobiol. Section Abstract Doc Link 15551346 Disease Relevance 0.36 Pain Relevance 0.38
The potentiating effect of APL on nicotinic neurotransmission has been shown by whole-cell patch-clamp studies in natural murine and human neurons, and in murine and human cell lines expressing various subtypes of neuronal nAChR.
Gene_expression (expressing) of nAChR in neuronal
5) Confidence 0.22 Published 2000 Journal Behav. Brain Res. Section Abstract Doc Link 10942046 Disease Relevance 0.07 Pain Relevance 0.35
9 subunit (and therefore silencing of the nAChR) suggests a relationship between the nicotinic and GABAergic systems at the level of gene expression, but a causal link has yet to be demonstrated.
Gene_expression (expression) of nAChR associated with gabaergic
6) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816210 Disease Relevance 0.08 Pain Relevance 0.18
This study demonstrates that primary afferent cholinergic neurons produce tonic inhibition of spinal pain through nAChR, and that intrathecal administration of nicotine rescues the loss of tonic cholinergic inhibition.
Gene_expression (produce) of nAChR in spinal associated with low back pain, pain, nicotine and intrathecal
7) Confidence 0.09 Published 2007 Journal Mol Pain Section Body Doc Link PMC2234393 Disease Relevance 0.71 Pain Relevance 1.24
As with M5R, the nAChR are co-expressed on dopamine neurones of the SNc and VTA [12].
Gene_expression (expressed) of nAChR associated with dopamine
8) Confidence 0.02 Published 2007 Journal BMC Genet Section Body Doc Link PMC1978498 Disease Relevance 0.55 Pain Relevance 1.08

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