INT5968

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Context Info
Confidence 0.65
First Reported 1992
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.36
Pain Relevance 2.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
macrophages 4
microglia 2
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 7 98.96 Very High Very High Very High
Inflammation 15 97.48 Very High Very High Very High
cytokine 16 95.84 Very High Very High Very High
adenocard 1 93.60 High High
anesthesia 2 86.56 High High
Intracerebroventricular 1 85.80 High High
Nav1.6 3 84.56 Quite High
sodium channel 8 79.64 Quite High
Nav1.9 1 79.00 Quite High
nav1.8 1 78.52 Quite High
Disease Link Frequency Relevance Heat
Necrosis 4 100.00 Very High Very High Very High
Cancer 1 100.00 Very High Very High Very High
Pneumonia 7 97.48 Very High Very High Very High
INFLAMMATION 18 96.36 Very High Very High Very High
Endotoxemia 5 96.24 Very High Very High Very High
Convulsion 2 92.08 High High
Stress 7 87.20 High High
Sepsis 38 67.60 Quite High
Brain Injury 21 50.00 Quite Low
Renal Failure 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar results were previously found after the injection of bacterial lipopolysaccharide, which induces the release of IL-1 from macrophages.
Positive_regulation (induces) of Localization (release) of IL-1 in macrophages
1) Confidence 0.65 Published 1992 Journal Endocrinology Section Abstract Doc Link 1319322 Disease Relevance 0.16 Pain Relevance 0.11
TTX (0.3 microM) reduced, but to a smaller extent, the release of IL-1 alpha, IL-1 beta, and TNF-alpha from activated microglia.
Positive_regulation (activated) of Localization (release) of IL-1 alpha in microglia associated with tetrodotoxin
2) Confidence 0.10 Published 2009 Journal Glia Section Abstract Doc Link 19115387 Disease Relevance 0 Pain Relevance 1.62
The peptide also binds to specific sites on human peripheral blood mononuclear cells and it evokes the release of tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6) from isolated rat macrophages in culture.
Positive_regulation (evokes) of Localization (release) of IL-1 in macrophages associated with necrosis and cancer
3) Confidence 0.03 Published 1995 Journal Life Sci. Section Abstract Doc Link 8614240 Disease Relevance 0.38 Pain Relevance 0.22
The secretion of mature and bioactive IL-1ß and IL-18 depends on the activity of the enzyme caspase-1, a limiting step in the biosynthesis of these pro-inflammatory cytokines.
Positive_regulation (depends) of Localization (secretion) of IL-1 associated with inflammation and cytokine
4) Confidence 0.02 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 0.82 Pain Relevance 0.46

General Comments

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