INT5969

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2010
Negated 7
Speculated 6
Reported most in Abstract
Documents 221
Total Number 227
Disease Relevance 96.31
Pain Relevance 71.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Il1a) extracellular space (Il1a) extracellular region (Il1a)
Anatomy Link Frequency
plasma 6
chondrocytes 4
macrophage 3
nucleus 3
brain 3
Il1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 2829 100.00 Very High Very High Very High
cytokine 2184 100.00 Very High Very High Very High
antagonist 425 100.00 Very High Very High Very High
metalloproteinase 138 100.00 Very High Very High Very High
substance P 114 100.00 Very High Very High Very High
nMDA receptor 68 100.00 Very High Very High Very High
Etanercept 26 100.00 Very High Very High Very High
headache 10 100.00 Very High Very High Very High
Infliximab 8 100.00 Very High Very High Very High
Adalimumab 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 3076 100.00 Very High Very High Very High
Adhesions 74 100.00 Very High Very High Very High
Urological Neuroanatomy 50 100.00 Very High Very High Very High
Headache 37 100.00 Very High Very High Very High
Rheumatoid Arthritis 178 99.96 Very High Very High Very High
Cancer 578 99.92 Very High Very High Very High
Heat Stroke 684 99.82 Very High Very High Very High
Hyperalgesia 511 99.82 Very High Very High Very High
Ganglion Cysts 35 99.82 Very High Very High Very High
Pneumonia 30 99.70 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), extracellular signal-regulated kinase (ERK), Jun, and p-38 were determined by Western blotting and RT-PCR.
Spec (determined) Gene_expression (Expression) of IL-1alpha
1) Confidence 0.75 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 16024175 Disease Relevance 0.73 Pain Relevance 0.14
Antiinflammatory properties of E5090, a novel orally active inhibitor of IL-1 generation.
Gene_expression (generation) of IL-1 associated with inflammation
2) Confidence 0.74 Published 1991 Journal Agents Actions Suppl. Section Title Doc Link 2069090 Disease Relevance 0.92 Pain Relevance 0.32
[Effect of intrahippocampal microinjection of enkephalin on cellular immune function and brain IL-1 alpha gene expression in rat].
Gene_expression (expression) of IL-1 alpha gene in brain associated with enkephalin
3) Confidence 0.68 Published 1996 Journal Sheng Li Xue Bao Section Title Doc Link 9389197 Disease Relevance 0 Pain Relevance 0.77
The above results suggested that intrahippocampal enkephalin might play an important role in neuro-immunomodulation by enhancing the inhibition of IL-1 alpha gene expression in hippocampal formation.
Gene_expression (expression) of IL-1 alpha gene in hippocampal formation associated with enkephalin
4) Confidence 0.68 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389197 Disease Relevance 0 Pain Relevance 0.77
The effect of intrahippocampal microinjection of enkephalin on cellular immune function and hippocampal IL-1 alpha gene expression was studied in rats.
Gene_expression (expression) of IL-1 alpha gene associated with enkephalin
5) Confidence 0.68 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389197 Disease Relevance 0 Pain Relevance 0.51
The LPS-induced IL-1 alpha gene expression in hippocampus could no longer be detected 30 min after microinjection of Met- or Leu-enkephalin into hippocampus.
Gene_expression (expression) of IL-1 alpha gene in hippocampus associated with enkephalin and hippocampus
6) Confidence 0.68 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389197 Disease Relevance 0 Pain Relevance 0.83
Low doses of Leu- or Met-enkephalin (10(-10), 10(-11) mol/L) were also capable of causing proliferative activity of the Con A- stimulated cultured splenic lymphocytes in vitro. (2) Using RT-PCR technique, IL-1 alpha gene expression was detected in hippocampus 90 min after bilateral intrahippocampal injection of LPS.
Gene_expression (expression) of IL-1 alpha gene in hippocampus associated with hippocampus and enkephalin
7) Confidence 0.68 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389197 Disease Relevance 0 Pain Relevance 0.83
METHODS: The pain-related parameters and the expression of IL-1RI and IL-1beta positive neurons and glia cells of DRG in normal saline (NS) and adjuvant-induced arthritic (AA) group were examined with pain behavior assessment methods and immunohistochemical assay, respectively.
Gene_expression (expression) of IL-1RI in DRG
8) Confidence 0.66 Published 2005 Journal Acta Pharmacol. Sin. Section Body Doc Link 15663898 Disease Relevance 0.10 Pain Relevance 0
The present study demonstrates that intrathecal injection of interleukin-1 (IL-1) in rats at a dose of 50 pg or 500 pg induced a significant hyperalgesic effect in the hot-plate test.
Gene_expression (injection) of IL-1 associated with hyperalgesia and intrathecal
9) Confidence 0.66 Published 2001 Journal Drugs Exp Clin Res Section Abstract Doc Link 11447771 Disease Relevance 0.56 Pain Relevance 0.31
AIM: To localize interleukin-1 receptor type I (IL-1RI) in rat dental pulp and trigeminal ganglion (TG) and to test the hypothesis that pulpal inflammation increases neuronal expression of IL-1RI.
Gene_expression (expression) of IL-1RI in dental pulp associated with ganglion cysts, inflammation and trigeminal ganglion
10) Confidence 0.64 Published 2009 Journal Int Endod J Section Abstract Doc Link 19732182 Disease Relevance 0.42 Pain Relevance 0.25
Pulpal inflammation significantly increased the expression of IL-1RI in the TG (P < 0.001).
Gene_expression (expression) of IL-1RI
11) Confidence 0.64 Published 2009 Journal Int Endod J Section Body Doc Link 19732182 Disease Relevance 0.11 Pain Relevance 0
Sensory pulpal nerve fibres and trigeminal ganglion neurons express IL-1RI: a potential mechanism for development of inflammatory hyperalgesia.
Gene_expression (express) of IL-1RI in neurons associated with ganglion cysts, hyperalgesia, inflammation and trigeminal ganglion neurons
12) Confidence 0.64 Published 2009 Journal Int Endod J Section Title Doc Link 19732182 Disease Relevance 0.30 Pain Relevance 0.29
The bone-resorptive cytokines interleukin 1 (IL-1) and tumor necrosis factor (TNF) have been implicated in the pathogenesis of many chronic inflammatory diseases, including pulpitis and apical periodontitis.To further elucidate their role in these disorders, we have identified cells that express IL-1 alpha and TNF alpha in infected pulps and in developing rat periapical lesions after surgical pulp exposure.
Gene_expression (express) of IL-1 alpha associated with necrosis, inflammation, cancer, pulpitis, periapical periodontitis, disease and cytokine
13) Confidence 0.64 Published 1995 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 8602333 Disease Relevance 0.58 Pain Relevance 0.27
Cells expressing IL-1 alpha and TNF alpha were identified primarily as macrophages and fibroblasts, with occasional staining of polymorphonuclear leukocytes.
Gene_expression (expressing) of IL-1 alpha in polymorphonuclear leukocytes
14) Confidence 0.64 Published 1995 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 8602333 Disease Relevance 0.51 Pain Relevance 0.30
In contrast, cells expressing IL-1 beta and TNF beta, the homologous forms of these mediators, were not found in pulp or periapical lesions during this period.
Gene_expression (expressing) of IL-1
15) Confidence 0.64 Published 1995 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 8602333 Disease Relevance 0.53 Pain Relevance 0.30
These findings demonstrate that cells that express bone-resorptive cytokines IL-1 alpha and TNF alpha are present immediately after pulp exposure in this model, which supports the hypothesis that these mediators play a key role in pulpal and periapical pathogenesis, including the concomitant bone destruction.
Gene_expression (express) of IL-1 alpha associated with cytokine
16) Confidence 0.64 Published 1995 Journal Oral Microbiol. Immunol. Section Abstract Doc Link 8602333 Disease Relevance 0.44 Pain Relevance 0.32
Administration of interleukin-1 (IL-1) induces increases in plasma ACTH and glucocorticoids.
Gene_expression (Administration) of IL-1 in plasma
17) Confidence 0.63 Published 1992 Journal Endocrinology Section Abstract Doc Link 1319322 Disease Relevance 0.07 Pain Relevance 0
The levels of TNF, IL-1 and IL-6 in circulating blood of female WAG/Rij rats were assessed both after total-body irradiation (TBI) and localized irradiation of the right hind leg.
Gene_expression (levels) of IL-1 in body
18) Confidence 0.63 Published 1998 Journal Oncol. Rep. Section Abstract Doc Link 9538175 Disease Relevance 0.08 Pain Relevance 0.11
To determine whether this reversal of IL-1 suppression of the LH surge was due to NAL action at the hypothalamic level, the preoptic area-medial basal hypothalamus of similarly primed ovx rats was obtained at 1300 h and incubated in vitro in the presence of 10 nM IL-1 alpha or IL-1 beta with or without 100 micrograms/ml NAL.
Gene_expression (suppression) of IL-1 in hypothalamus
19) Confidence 0.62 Published 1990 Journal Endocrinology Section Abstract Doc Link 2226323 Disease Relevance 0 Pain Relevance 0.40
APZ was shown to be a potent inhibitor of the production of leucocyte superoxide and synovial interleukin-1 (IL-1)-like activity and stimulated articular cartilage proteoglycan synthesis, but was ineffective as an inhibitor of platelet aggregation or IL-1 induced cartilage degradation in-vitro.
Gene_expression (production) of IL-1 in cartilage
20) Confidence 0.61 Published 1989 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2569519 Disease Relevance 0.17 Pain Relevance 0.13

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