INT59696

Context Info Confidence 0.65 First Reported 1993 Last Reported 1993 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.23 Pain Relevance 0.70

lipid binding (AP2M1) cytosol (AP2M1) transport (AP2M1) mitochondrion (AP2M1) vesicle-mediated transport (AP2M1) plasma membrane (AP2M1)

AP2M1 (Homo sapiens)

Pain Link Frequency Relevance Heat agonist 2 100.00 Morphine 1 99.90 Equianalgesic 1 96.96 Antinociceptive 2 88.16 antinociception 1 87.64 narcan 3 84.16 antagonist 1 81.68 analgesia 1 75.00 Opioid 1 75.00 depression 1 63.04

Disease Link Frequency Relevance Heat Catalepsy 2 93.12 Respiratory Failure 1 64.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Morphine, an agonist at both mu 1 and mu 2 sites, at a dose of 150 nmol i.c.v.

Gene_expression (agonist) of mu 2 associated with agonist and morphine

1) Confidence 0.65 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8394909 Disease Relevance 0.23 Pain Relevance 0.70

General Comments

This test has worked.