INT59705

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Context Info
Confidence 0.67
First Reported 1993
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.26
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1D) signal transducer activity (HTR1D)
Anatomy Link Frequency
umbilical vein 2
embryos 1
blood vessels 1
brain 1
beta cell 1
HTR1D (Homo sapiens)
Pain Link Frequency Relevance Heat
Serotonin 19 99.98 Very High Very High Very High
medulla 4 97.52 Very High Very High Very High
Spinal cord 4 96.60 Very High Very High Very High
Sumatriptan 14 90.80 High High
agonist 7 82.84 Quite High
cerebral cortex 1 80.08 Quite High
antagonist 2 73.68 Quite High
Central nervous system 1 73.16 Quite High
Migraine 5 72.64 Quite High
Substantia nigra 1 67.36 Quite High
Disease Link Frequency Relevance Heat
Headache 5 72.64 Quite High
Urological Neuroanatomy 5 57.04 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, Northern blots revealed the presence of mRNA transcripts for the 5-HT1D beta subtype, but not the 5-HT1D alpha subtype, in bovine (approximately 2.2 kilobases) and human (approximately 4.5 kilobases) cerebral blood vessels.
Transcription (transcripts) of 5-HT1D in blood vessels
1) Confidence 0.67 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394988 Disease Relevance 0.21 Pain Relevance 0.62
Constitutive mRNA for 5-HT2A receptors was present in control and transfected C6 glial/5-HT1D beta cells, whereas mRNA for 5-HT1D beta receptor sites was only present in the transfected C6 glial/5-HT1D beta cell line. 5-HT inhibited forskolin-stimulated cyclic AMP formation and promoted cell growth, in contrast to the absence of any measurable effect in pcDNA3 plasmid-transfected and nontransfected C6 glial cells.
Transcription (present) of 5-HT1D in beta cell
2) Confidence 0.67 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8522991 Disease Relevance 0 Pain Relevance 0.18
We report on the autoradiographic distribution of 5-HT1B, 5-HT1D and 5-HT1F receptor subtypes in human brain, focusing on the brainstem and cervical spinal cord.
Transcription (distribution) of 5-HT1D in brain associated with medulla and spinal cord
3) Confidence 0.67 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225278 Disease Relevance 0.06 Pain Relevance 0.62
Functional serotonin 5-HT1D receptors and 5-HT1D beta receptor mRNA expression in human umbilical vein endothelial cells.
Transcription (expression) of 5-HT1D in umbilical vein associated with serotonin
4) Confidence 0.52 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 8751089 Disease Relevance 0 Pain Relevance 0.29
Functional serotonin 5-HT1D receptors and 5-HT1D beta receptor mRNA expression in human umbilical vein endothelial cells.
Transcription (expression) of 5-HT1D in umbilical vein associated with serotonin
5) Confidence 0.52 Published 1995 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Title Doc Link 8751089 Disease Relevance 0 Pain Relevance 0.29
Serotonin 5-HT1D receptor mRNA was present in unfertilized oocytes, zygotes, 2-cell embryos, compacted morulae and in vivo produced expanded blatocysts.
Transcription (present) of 5-HT1D in embryos associated with serotonin
6) Confidence 0.52 Published 2003 Journal Physiol Res Section Abstract Doc Link 12678665 Disease Relevance 0 Pain Relevance 0.59

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