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Context Info
Confidence 0.69
First Reported 1993
Last Reported 2006
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.40
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR1B) cytoplasm (HTR1B) signal transducer activity (HTR1B)
Anatomy Link Frequency
embryos 1
dorsal 1
blood vessels 1
nerve 1
brain 1
HTR1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Raphe 3 99.98 Very High Very High Very High
fluoxetine 8 99.80 Very High Very High Very High
sSRI 2 99.58 Very High Very High Very High
Serotonin 21 99.52 Very High Very High Very High
medulla 4 97.20 Very High Very High Very High
Spinal cord 4 96.28 Very High Very High Very High
Neurotransmitter 3 93.92 High High
Sumatriptan 10 90.16 High High
antidepressant 6 86.40 High High
Central nervous system 1 80.16 Quite High
Disease Link Frequency Relevance Heat
Headache 5 70.40 Quite High
Depression 2 68.64 Quite High
Urological Neuroanatomy 5 56.40 Quite High
Pain 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of T3, alone and together with the SSRI fluoxetine, on mRNA levels for the 5-HT1A and 5-HT1B autoreceptors, which mediate serotonergic neurotransmission by feedback actions at the levels of cell firing(somatodendritic 5-HT1A autoreceptors) and neurotransmitter release (nerve terminal 5-HT1B autoreceptors) were also determined.
Spec (determined) Transcription (levels) of 5-HT1B in nerve associated with neurotransmitter, ssri and fluoxetine
1) Confidence 0.69 Published 2006 Journal Curr Drug Targets Section Abstract Doc Link 16475961 Disease Relevance 0 Pain Relevance 0.55
We report on the autoradiographic distribution of 5-HT1B, 5-HT1D and 5-HT1F receptor subtypes in human brain, focusing on the brainstem and cervical spinal cord.
Transcription (distribution) of 5-HT1B in brain associated with medulla and spinal cord
2) Confidence 0.67 Published 1997 Journal Neuropharmacology Section Abstract Doc Link 9225278 Disease Relevance 0.06 Pain Relevance 0.62
However, fluoxetine reduced dorsal raphe 5-HT1B mRNA levels in a time-dependent and washout-reversible manner.
Transcription (levels) of 5-HT1B in dorsal associated with raphe and fluoxetine
3) Confidence 0.52 Published 1996 Journal Neuropsychopharmacology Section Abstract Doc Link 8914125 Disease Relevance 0.14 Pain Relevance 1.14
Transcripts for 5-HT1B and 5-HT2C serotonin receptors were detected neither in unfertilized oocytes nor at any stages of in vivo developing preimplantation embryos.
Transcription (Transcripts) of 5-HT1B in embryos associated with serotonin
4) Confidence 0.52 Published 2003 Journal Physiol Res Section Abstract Doc Link 12678665 Disease Relevance 0 Pain Relevance 0.53
However, Northern blots revealed the presence of mRNA transcripts for the 5-HT1D beta subtype, but not the 5-HT1D alpha subtype, in bovine (approximately 2.2 kilobases) and human (approximately 4.5 kilobases) cerebral blood vessels.
Transcription (transcripts) of 5-HT1D beta in blood vessels
5) Confidence 0.44 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394988 Disease Relevance 0.20 Pain Relevance 0.56

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