INT59709

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Context Info
Confidence 0.57
First Reported 1993
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.07
Pain Relevance 2.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (YY1) chromosome organization (YY1) RNA binding (YY1)
plasma membrane (YY1) nucleus (YY1) intracellular (YY1)
Anatomy Link Frequency
SK-N-SH 2
YY1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 11 100.00 Very High Very High Very High
narcan 1 99.58 Very High Very High Very High
Opioid 4 98.72 Very High Very High Very High
tolerance 4 98.44 Very High Very High Very High
Morphine 9 98.16 Very High Very High Very High
antagonist 1 96.92 Very High Very High Very High
Enkephalin 12 94.48 High High
mu opioid receptor 8 92.80 High High
opioid receptor 13 86.72 High High
Delta opioid receptors 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of SK-N-SH cells with beta-funaltrexamine prevented down-regulation of delta receptors in response to chronic exposure to morphine but did not affect down-regulation of delta receptors in response to D-Pen2,D-Pen5-enkephalin.
Negative_regulation (prevented) of Negative_regulation (down-regulation) of delta in SK-N-SH associated with enkephalin and morphine
1) Confidence 0.57 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394999 Disease Relevance 0.07 Pain Relevance 1.26
This study was designed to test the hypothesis that inhibition of agonist-induced delta-receptor down-regulation would block the development of opioid tolerance in a cell-based model.
Negative_regulation (inhibition) of Negative_regulation (regulation) of delta associated with tolerance, agonist and opioid
2) Confidence 0.57 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17159161 Disease Relevance 0 Pain Relevance 0.80
Chromatin immunoprecipitation assays showed that the blockage of naloxone is achieved through down-regulation of transcription factor YY1.
Negative_regulation (down) of Negative_regulation (regulation) of transcription factor YY1 associated with narcan
3) Confidence 0.34 Published 2008 Journal J. Cell. Biochem. Section Abstract Doc Link 17990281 Disease Relevance 0 Pain Relevance 0.48

General Comments

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