INT5971

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Context Info
Confidence 0.51
First Reported 1992
Last Reported 1994
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.57
Pain Relevance 0.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1a, Crh) extracellular region (Il1a, Crh) cytosol (Il1a)
response to stress (Crh) cytoplasm (Crh)
Anatomy Link Frequency
hypothalamus 2
neurosecretory cells 1
Il1a (Rattus norvegicus)
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 1 97.72 Very High Very High Very High
Opioid 2 92.04 High High
Intracerebroventricular 6 75.00 Quite High
Serotonin 4 75.00 Quite High
Catecholamine 4 75.00 Quite High
Inflammatory mediators 1 60.08 Quite High
antagonist 4 58.24 Quite High
cytokine 2 28.32 Quite Low
Disease Link Frequency Relevance Heat
Stress 8 99.32 Very High Very High Very High
INFLAMMATION 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interleukin-1 (IL-1) is a potent activator of the corticotropin-releasing hormone (CRH) system in the hypothalamus, and it has been shown to be involved in many stress responses, including immunosuppression.
IL-1 Positive_regulation (activator) of CRH in hypothalamus associated with stress
1) Confidence 0.51 Published 1994 Journal Endocrinology Section Abstract Doc Link 7925095 Disease Relevance 0.20 Pain Relevance 0.29
Interleukin-1 (IL-1) is a potent activator of the corticotropin-releasing hormone (CRH) system in the hypothalamus, and it has been shown to be involved in many stress responses, including immunosuppression.
IL-1 Positive_regulation (activator) of corticotropin-releasing hormone in hypothalamus associated with stress
2) Confidence 0.51 Published 1994 Journal Endocrinology Section Abstract Doc Link 7925095 Disease Relevance 0.20 Pain Relevance 0.29
The findings unequivocally establish for the first time that IL-1 activates hypothalamic CRH neurosecretory cells in the absence of surgical stress, anesthesia, disruption of the infundibular area, or administration of toxic drugs.
IL-1 Positive_regulation (activates) of CRH in neurosecretory cells associated with stress and anesthesia
3) Confidence 0.38 Published 1992 Journal Endocrinology Section Abstract Doc Link 1319322 Disease Relevance 0.17 Pain Relevance 0.13

General Comments

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