INT59712

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Context Info
Confidence 0.21
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.23
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PSENEN) Golgi apparatus (PSENEN) endoplasmic reticulum (PSENEN)
plasma membrane (PSENEN)
Anatomy Link Frequency
SK-N-SH 1
PSENEN (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 3 99.68 Very High Very High Very High
Morphine 7 98.84 Very High Very High Very High
opioid receptor 3 93.68 High High
antagonist 1 91.08 High High
mu opioid receptor 1 86.96 High High
Delta opioid receptors 4 75.00 Quite High
agonist 2 61.24 Quite High
MU agonist 1 55.00 Quite High
Immobilon 1 51.96 Quite High
Analgesic 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Toxicity 1 83.80 Quite High
Neuroblastoma 2 75.00 Quite High
Disease 14 69.48 Quite High
Alzheimer's Dementia 15 50.00 Quite Low
Targeted Disruption 1 40.56 Quite Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Infection 3 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Death 1 5.00 Very Low Very Low Very Low
Aging 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of SK-N-SH cells with beta-funaltrexamine prevented down-regulation of delta receptors in response to chronic exposure to morphine but did not affect down-regulation of delta receptors in response to D-Pen2,D-Pen5-enkephalin.
Positive_regulation (response) of D-Pen2 in SK-N-SH associated with enkephalin and morphine
1) Confidence 0.21 Published 1993 Journal Mol. Pharmacol. Section Abstract Doc Link 8394999 Disease Relevance 0.07 Pain Relevance 1.19
These data show directly that changes in PS1 conformation can be detected following various manipulations of PS1 itself, Pen2, Aph1, APP, and pharmacological agents known as ?
Positive_regulation (manipulations) of Pen2
2) Confidence 0.10 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.15 Pain Relevance 0
40, and do so without the apparent need of the co-factors APH-1, nicastrin, and PEN-2 that are required for ?
Positive_regulation (required) of PEN-2
3) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2947513 Disease Relevance 0 Pain Relevance 0

General Comments

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