INT59719

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Context Info
Confidence 0.78
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 8.40
Pain Relevance 2.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SELP) cell adhesion (SELP) nucleolus (SELP)
plasma membrane (SELP) nucleus (SELP) cytoplasm (SELP)
Anatomy Link Frequency
platelets 7
Plasma 2
plaques 1
external jugular vein 1
T cell 1
SELP (Homo sapiens)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 4 100.00 Very High Very High Very High
depression 10 99.52 Very High Very High Very High
aspirin 38 99.22 Very High Very High Very High
Migraine 4 98.72 Very High Very High Very High
metalloproteinase 5 98.24 Very High Very High Very High
Inflammation 155 94.56 High High
antagonist 26 92.64 High High
agonist 12 90.92 High High
trigeminal ganglion 1 84.20 Quite High
Angina 25 82.96 Quite High
Disease Link Frequency Relevance Heat
Depression 10 99.52 Very High Very High Very High
Nicotine Addiction 366 99.48 Very High Very High Very High
Headache 3 98.72 Very High Very High Very High
Heart Rate Under Development 66 98.16 Very High Very High Very High
Rupture 1 95.32 Very High Very High Very High
Scotoma 1 94.60 High High
INFLAMMATION 179 94.56 High High
Migraine With Aura 1 92.28 High High
Disease 241 89.96 High High
Adhesions 192 89.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet activation markers for ex vivo analysis may include a) activation-dependent epitopes of the membrane glycoprotein (GP) IIb/IIIa (CD41a) receptor, as demonstrated by the binding of activation-specific monoclonal antibodies (MoAbs) PAC1, anti-LIBS1 and anti-RIBS); b) the expression of P-selectin (CD62p), the alpha-granule GP translocated to the platelet surface following release reaction; and c) platelet procoagulant activity, as demonstrated by the binding of i) annexin V protein to the prothrombinase-complex (prothrombin, activated factor X (Xa) and V (Va)) binding sites on the surface of activated platelets, and of ii) MoAbs against activated coagulation factors V and X bound to the surface of activated platelets.
Localization (translocated) of CD62p in platelets
1) Confidence 0.78 Published 2004 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 15471223 Disease Relevance 0.10 Pain Relevance 0.03
Immunolocalization of platelet glycoprotein IIb/IIIa and P-selectin, and neutrophil-platelet interaction in human coronary unstable plaques.
Localization (Immunolocalization) of P-selectin in plaques
2) Confidence 0.77 Published 2005 Journal Int. J. Mol. Med. Section Title Doc Link 15754016 Disease Relevance 0.78 Pain Relevance 0.61
Platelet activation markers for ex vivo analysis may include a) activation-dependent epitopes of the membrane glycoprotein (GP) IIb/IIIa (CD41a) receptor, as demonstrated by the binding of activation-specific monoclonal antibodies (MoAbs) PAC1, anti-LIBS1 and anti-RIBS); b) the expression of P-selectin (CD62p), the alpha-granule GP translocated to the platelet surface following release reaction; and c) platelet procoagulant activity, as demonstrated by the binding of i) annexin V protein to the prothrombinase-complex (prothrombin, activated factor X (Xa) and V (Va)) binding sites on the surface of activated platelets, and of ii) MoAbs against activated coagulation factors V and X bound to the surface of activated platelets.
Localization (translocated) of P-selectin in platelets
3) Confidence 0.68 Published 2004 Journal J. Biol. Regul. Homeost. Agents Section Abstract Doc Link 15471223 Disease Relevance 0.10 Pain Relevance 0.03
M) significantly inhibited the percentage of P-selectin positive platelets by 35.8±3.5% (mean ± SEM) (n?
Localization (platelets) of P-selectin in platelets
4) Confidence 0.64 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0 Pain Relevance 0.24
Anti-CD61, anti-CD62P and anti-PAC1 antibodies were from BD, USA.
Localization (were) of CD62P
5) Confidence 0.64 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096644 Disease Relevance 0 Pain Relevance 0
For these reasons, which may confound the interpretation of the functional state of P2Y12, we elected to measure surface translocation of P-selectin as an activation marker possibly more directly linked to ADP-induced platelet stimulation, as well as PAC-1 binding that, by reflecting GP IIb-IIIa activation, provides information consistent with that of aggregation assays.
Localization (translocation) of P-selectin in platelet associated with heart rate under development
6) Confidence 0.62 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.10 Pain Relevance 0.05
It is noteworthy, in this regard, that measuring the surface translocation of P-selectin in platelets stimulated in the presence of PG E1 appears to be more sensitive to the therapeutic inhibition of P2Y12 than measuring GP IIb-IIIa activation (as reflected by PAC-1 binding).
Localization (translocation) of P-selectin in platelets associated with heart rate under development
7) Confidence 0.62 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.30 Pain Relevance 0.08
In fact, several patients treated with the aspirin/clopidogrel combination had levels of P-selectin surface translocation below the 1st quartile of normal values when PAC-1 binding was above this limit.
Localization (translocation) of P-selectin associated with aspirin and heart rate under development
8) Confidence 0.62 Published 2009 Journal Thromb J Section Body Doc Link PMC2683811 Disease Relevance 0.26 Pain Relevance 0.08
Accordingly, it has been shown that P-selectin expression is generally increased on the surface of platelets in smokers, a process that requires translocation of P-selectin from the intracellular ?
Localization (translocation) of P-selectin in platelets associated with nicotine addiction
9) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.89 Pain Relevance 0.19
Accordingly, it has been shown that P-selectin expression is generally increased on the surface of platelets in smokers, a process that requires translocation of P-selectin from the intracellular ?
Localization (translocation) of P-selectin in platelets associated with nicotine addiction
10) Confidence 0.51 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.89 Pain Relevance 0.19
Plasma profiling of SJIA flare and quiescent samples using this antibody array identified a biomarker panel of TIMP1, IL-18, RANTES, P-Selectin, MMP9, and L-Selectin, all of which are present at higher abundance in SJIA flare than in quiescence.
Localization (panel) of P-Selectin in Plasma
11) Confidence 0.32 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.72 Pain Relevance 0.25
The antibody array plasma profiling identified an SJIA plasma flare signature consisting of tissue inhibitor of metalloproteinase-1 (TIMP1), interleukin (IL)-18, regulated upon activation, normal T cell expressed and secreted (RANTES), P-Selectin, MMP9, and L-Selectin.


Localization (secreted) of P-Selectin in T cell associated with metalloproteinase
12) Confidence 0.30 Published 2010 Journal Clin Proteomics Section Abstract Doc Link PMC2970804 Disease Relevance 0.72 Pain Relevance 0.15
Identification of TIMP1, IL18, RANTES, P-Selectin, MMP9, and L-Selectin as SJIA Plasma Flare Biomarkers
Localization (Identification) of P-Selectin in Plasma
13) Confidence 0.14 Published 2010 Journal Clin Proteomics Section Body Doc Link PMC2970804 Disease Relevance 0.49 Pain Relevance 0.17
Cortical spreading depression does not result in the release of calcitonin gene-related peptide into the external jugular vein of the cat: relevance to human migraine.
Localization (release) of external jugular vein in external jugular vein associated with depression, migraine and calcitonin gene-related peptide
14) Confidence 0.02 Published 1993 Journal Cephalalgia Section Title Doc Link 8395344 Disease Relevance 1.06 Pain Relevance 0.90

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