INT5972

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Context Info
Confidence 0.78
First Reported 1986
Last Reported 2011
Negated 26
Speculated 24
Reported most in Abstract
Documents 948
Total Number 972
Disease Relevance 510.91
Pain Relevance 263.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
macrophages 44
monocytes 39
chondrocytes 27
blood 19
cartilage 16
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 10932 100.00 Very High Very High Very High
cytokine 10612 100.00 Very High Very High Very High
Osteoarthritis 5566 100.00 Very High Very High Very High
Arthritis 3226 100.00 Very High Very High Very High
metalloproteinase 1787 100.00 Very High Very High Very High
Pain 1570 100.00 Very High Very High Very High
antagonist 1392 100.00 Very High Very High Very High
chemokine 983 100.00 Very High Very High Very High
Inflammatory mediators 414 100.00 Very High Very High Very High
depression 335 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 12256 100.00 Very High Very High Very High
Osteoarthritis 4952 100.00 Very High Very High Very High
Cancer 2634 100.00 Very High Very High Very High
Arthritis 2528 100.00 Very High Very High Very High
Infection 1383 100.00 Very High Very High Very High
Pain 1330 100.00 Very High Very High Very High
Adhesions 1163 100.00 Very High Very High Very High
Necrosis 974 100.00 Very High Very High Very High
Herpes Simplex Virus 515 100.00 Very High Very High Very High
Depression 372 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific expression of interleukin-1 beta in temporomandibular joints with internal derangement: correlation with clinical findings.
Gene_expression (expression) of interleukin-1 beta in temporomandibular joints
1) Confidence 0.78 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Title Doc Link 10519747 Disease Relevance 0 Pain Relevance 0.09
The evaluation of interleukin-1 beta expression compared with clinical findings.
Gene_expression (expression) of interleukin-1 beta
2) Confidence 0.78 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 10519747 Disease Relevance 0.16 Pain Relevance 0
The aim of this study was to analyze the expression of interleukin-1 beta in temporomandibular joint internal derangement.
Spec (analyze) Gene_expression (expression) of interleukin-1 beta in temporomandibular joint associated with snapping jaw
3) Confidence 0.78 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Abstract Doc Link 10519747 Disease Relevance 0.10 Pain Relevance 0.10
CONCLUSIONS: The results suggest that interleukin-1 beta may be involved in the pathogenesis of temporomandibular joint internal derangement and that the intensity of interleukin-1 beta expression may correlate with clinical findings, especially pain.


Gene_expression (expression) of interleukin-1 beta in temporomandibular joint
4) Confidence 0.78 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 10519747 Disease Relevance 0.13 Pain Relevance 0
Statistically significant correlation was found between interleukin-1 beta expression and some clinical findings.
Spec (findings) Gene_expression (expression) of interleukin-1 beta
5) Confidence 0.78 Published 1999 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 10519747 Disease Relevance 0.14 Pain Relevance 0
This difference could not be explained by differences in kinetics of IL1-beta gene expression between the 2 cell types, isolation techniques, or alveolar macrophage lidocaine exposure.
Gene_expression (expression) of IL1-beta in alveolar macrophage associated with lidocaine
6) Confidence 0.78 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.21 Pain Relevance 0.10
Interleukin-1-beta gene expression in human monocytes and alveolar macrophages from normal subjects and patients with sarcoidosis.
Gene_expression (expression) of Interleukin-1-beta in monocytes associated with sarcoidosis
7) Confidence 0.78 Published 1988 Journal Am. Rev. Respir. Dis. Section Title Doc Link 3264123 Disease Relevance 0.22 Pain Relevance 0.07
To assess the ability of human alveolar macrophages to produce interleukin-1-beta (IL1-beta), we examined IL1-beta mRNA accumulation in autologous monocytes and alveolar macrophages from normal volunteers.
Gene_expression (produce) of IL1-beta in monocytes
8) Confidence 0.78 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.07 Pain Relevance 0.06
To determine if this difference in the capacity to express the IL1-beta gene might be a function of cell maturity, monocytes were aged in vitro for 7 days.
Gene_expression (express) of IL1-beta in monocytes
9) Confidence 0.78 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.53 Pain Relevance 0.13
To assess the ability of human alveolar macrophages to produce interleukin-1-beta (IL1-beta), we examined IL1-beta mRNA accumulation in autologous monocytes and alveolar macrophages from normal volunteers.
Gene_expression (produce) of interleukin-1-beta in monocytes
10) Confidence 0.78 Published 1988 Journal Am. Rev. Respir. Dis. Section Abstract Doc Link 3264123 Disease Relevance 0.07 Pain Relevance 0.06
Gold compounds inhibited IL-1 activity, but only auranofin inhibited IL-1 production.
Gene_expression (production) of IL-1
11) Confidence 0.78 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.22 Pain Relevance 0.38
IL-1 activity and production were measured by its effect on the proliferation of murine thymocytes; IL-1 inhibitor production was assayed by inhibition of IL-1 mediated thymocyte proliferation.
Gene_expression (production) of IL-1 in thymocytes
12) Confidence 0.78 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.35
Dexamethasone (10-100 nM) inhibited IL-1 production and IL-1 mediated thymocyte proliferation.
Gene_expression (production) of IL-1 in thymocyte associated with dexamethasone
13) Confidence 0.78 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.25 Pain Relevance 0.38
Colchicine inhibited IL-1 activity but not IL-1 production.
Gene_expression (production) of IL-1
14) Confidence 0.78 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.20 Pain Relevance 0.36
Methotrexate inhibited IL-1 activity without affecting IL-1 production.
Gene_expression (production) of IL-1 associated with methotrexate
15) Confidence 0.78 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.24 Pain Relevance 0.39
No drug tested induced, by itself, the production of IL-1 inhibitor or enhanced the production of IL-1 inhibitor.
Gene_expression (production) of IL-1
16) Confidence 0.78 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.19 Pain Relevance 0.34
Acetaminophen in high concentrations (1 mg/ml) inhibited IL-1 activity and production.
Gene_expression (production) of IL-1 associated with paracetamol
17) Confidence 0.78 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.21 Pain Relevance 0.37
The effect of antirheumatic drugs on interleukin 1 (IL-1) activity and IL-1 and IL-1 inhibitor production by human monocytes.
Gene_expression (production) of IL-1 in monocytes associated with methotrexate
18) Confidence 0.78 Published 1990 Journal J. Rheumatol. Section Title Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.39
The objective of our study was to investigate the effect of a number of representative antirheumatic agents on the activity of IL-1 and the production of both IL-1 and IL-1 inhibitor by human monocytes.
Gene_expression (production) of IL-1 in monocytes
19) Confidence 0.78 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.26 Pain Relevance 0.27
Dexamethasone (10-100 nM) inhibited IL-1 production and IL-1 mediated thymocyte proliferation.
Gene_expression (production) of IL-1 in thymocyte associated with dexamethasone
20) Confidence 0.78 Published 1990 Journal J. Rheumatol. Section Abstract Doc Link 1981242 Disease Relevance 0.25 Pain Relevance 0.37

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