INT59722

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Context Info
Confidence 0.11
First Reported 1993
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.56
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc40a1) plasma membrane (Slc40a1)
Anatomy Link Frequency
neurons 1
lungs 1
Slc40a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 8 100.00 Very High Very High Very High
agonist 2 100.00 Very High Very High Very High
Morphine 12 99.48 Very High Very High Very High
fibrosis 7 99.42 Very High Very High Very High
tolerance 3 96.16 Very High Very High Very High
mu opioid receptor 5 94.64 High High
opioid receptor 2 94.48 High High
Analgesic 1 80.24 Quite High
Immobilon 5 80.04 Quite High
Opioid 1 78.08 Quite High
Disease Link Frequency Relevance Heat
Paracoccidioidomycosis 25 100.00 Very High Very High Very High
Fibrosis 6 99.42 Very High Very High Very High
Targeted Disruption 1 82.48 Quite High
INFLAMMATION 9 74.48 Quite High
Infection 9 57.60 Quite High
Congenital Anomalies 2 50.00 Quite Low
Decubitus Ulcers 1 40.12 Quite Low
Bronchiectasis 1 31.04 Quite Low
Emphysema 1 28.48 Quite Low
Granuloma 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pulmonary function analysis would respond to the following question: Do the large masses or the consolidated lesions observed in our study by HRCT or the fibrosis recorded by histopathology, decrease the normal function of lungs of mice with experimental PCM?
Negative_regulation (decrease) of PCM in lungs associated with paracoccidioidomycosis and fibrosis
1) Confidence 0.11 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2894136 Disease Relevance 0.48 Pain Relevance 0.09
We therefore examined, in cultured neurons, the relationship between muOR internalization and desensitization in response to two agonists, D-Ala2, N-MePhe4, Gly5-ol-enkephalin (DAMGO) and morphine.
Negative_regulation (desensitization) of Gly5-ol-enkephalin in neurons associated with agonist, enkephalin and morphine
2) Confidence 0.02 Published 2006 Journal Neuroscience Section Abstract Doc Link 16887280 Disease Relevance 0.08 Pain Relevance 0.71
Guanosine 5'-O-(3-thiotriphosphate), GTP, and guanosine 5'-O-(2-thiodiphosphate), but not adenylylimidodiphosphate, diminished [3H][D-Ala2,N-Me-Phe4,Gly5-ol] enkephalin binding in a concentration-dependent manner.
Negative_regulation (diminished) of Gly5-ol associated with enkephalin
3) Confidence 0.00 Published 1993 Journal J. Neurochem. Section Abstract Doc Link 8395567 Disease Relevance 0 Pain Relevance 0.93

General Comments

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